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Hydroxychloroquine Use During COVID Pandemic May Have Induced 17,000 Deaths, New Study Finds
Euronews ^ | 06/01/2024 | Oceane Duboust

Posted on 01/07/2024 1:23:13 PM PST by nickcarraway

The drug hydroxychloroquine was prescribed off-label during the pandemic and touted in particular by a prominent French researcher.

The antimalarial drug hydroxychloroquine may have induced nearly 17,000 deaths in six countries during the first wave of the COVID-19 pandemic.

This molecule was presented during the pandemic as a miracle cure by a minority of health professionals, among them the French microbiologist Didier Raoult.

The scientist’s belief that the drug was a cure for COVID-19 was soon echoed by some policymakers. French President Emmanuel Macron notably visited his facility and US President Donald Trump recommended the drug in 2020, stating that he had already taken it.

Avoiding COVID was about more than just keeping 2 metres apart, study finds The use of the drug sparked controversy as many health specialists noted the lack of research or scientific evidence of its effectiveness against COVID-19.

The US Food and Drug Administration (FDA) issued an emergency use authorisation of hydroxychloroquine (HCQ) in March 2020 but revoked it in June.

The drug was found in particular to cause severe side effects such as heart rhythm abnormalities.

Nearly 17,000 deaths induced by hydroxychloroquine A new study published in Biomedicine & Pharmacotherapy now estimates the fallout from the drug’s off-label use.

Researchers led by Jean-Christophe Lega, a Professor of Therapeutics in the Lyon, France hospital system, investigated studies conducted in France, the United States, Belgium, Italy, Spain, and Turkey from March 2020 until July 2020.

"HCQ use was associated with an 11 per cent increase in the mortality rate in a meta-analysis of randomised trials," the study noted, citing a meta-analysis published in 2021 in Nature which the researchers used to calculate the number of deaths induced by the drug.

'It’s not gone. It’s changing. It’s killing': The COVID variants the WHO is watching closely The estimated number of deaths in European countries was roughly 240 in Belgium, 199 in France, 1,822 in Italy, and 1,895 in Spain.

"What we need to bear in mind is that this is a rough estimate, in the sense that it only concerns a few countries over a short period, and that the total number of deaths is probably much higher," Lega told French broadcaster France 3.

The results should be taken with caution as it is a statistical analysis. One limitation of the study was that in France, Turkey, and Belgium, in particular, data concerning exposure to the drug was scarce.

Yet the researchers say: "This result argues in favour of tightly regulating access to off-label prescriptions during future pandemics".


TOPICS:
KEYWORDS: chinavirus; covid; covid1984; deathdrug; fakenews; followdirections; hcq; hydroxychloroquine; hyped; jeanchristophelega; mortality
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To: nickcarraway

Don’t believe it...same old story...they were going to die and this was the last recourse. Same old....of or with Covid.


101 posted on 01/07/2024 3:02:16 PM PST by Sacajaweau ( )
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To: Jane Long
"Truth be told, likely providing *other* benefits, as well."

I'm sure you're right about that.

102 posted on 01/07/2024 3:02:55 PM PST by mass55th (“Courage is being scared to death, but saddling up anyway.” ― John Wayne)
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To: nickcarraway
The study summarized a lot of studies and threw out most of them, ad then based their estimate by extrapolating the numbers from small study.
Some studies showed it worked.
anti virals have to be given early or they don't work.
And one study in Brazil gave larger doses to very sick people and larger doses can cause toxicity.
103 posted on 01/07/2024 3:05:32 PM PST by LadyDoc (liberals only love politically correct poor people)
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To: DugwayDuke

@ 85 No dug - the doctors you trust blatantly lied to your face.
1. If you take the ‘vaccines’ you won’t get covid or transmit it.
2. Naturally immunity is ineffective against covid and you must get the jab.
3. Kids with a 99.97% chance of surviving covid still need the covid vaccines.
4. Walking around with a dust mask will also protect against virus.

I could go on. It’s laughable the people you trust.


104 posted on 01/07/2024 3:06:32 PM PST by week 71
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To: Steve Van Doorn

Quercetin is a multiple P450 inhibitor. It is also P-gp inhibitor which is what protects the blood brain barrier.


105 posted on 01/07/2024 3:07:53 PM PST by RummyChick
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To: Jim Noble
said, "at my hospital, from January to May 2020 at the first two, I hung on to it through the end of June — but once the dexamethasone data was out and nobody saw any therapeutic effect from HCQ... "

HCQ and Quercetin only work on early stages of COVID. Once they're in ICU which this study used. Their respiration is shot.

That is when Peroxynitrite(-ONOO) in the lungs are to high. The body needs that to be under control or you're dead.

The last thing a person needs when -ONOO is to high is more oxygen in the lungs. Which they put people on respirators adding more oxygen creating more -ONOO. Then they drugged them to stay asleep because the body would force you away to remove the respirator.

What they needed was more oxygen in the blood NOT the lungs. Vitamin B1 Thiamine carries extra oxygen.
106 posted on 01/07/2024 3:09:49 PM PST by Steve Van Doorn
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To: nickcarraway

Probably because of incorrect dosage since no medical guidance was given for how to administer it. People would get there hands on and use the “if a little bit is good, a lot is better” approach and effectively overdose on it.


107 posted on 01/07/2024 3:13:27 PM PST by CarmichaelPatriot (Recovering Kalifornian... Loving Alabama!)
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To: CarmichaelPatriot

@107 - not an unfair point.


108 posted on 01/07/2024 3:15:15 PM PST by week 71
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To: stanne
Cardiac arrhythmia's are a known side effect of HQ overdoses.
And in Brazil they were using very high doses, something like 2000 mg a day not 500 mg which is the usual dose.

In the US HCQ is used for some diseases like Lupus. I took it 40 years ago when I worked in Africa but even then there was resistance and I got malaria.

In the 1990s one group supporting suicide recommended it as a painless way to kill oneself because there was no known treatment. Then some docs in Paris found an antidote and the death pushers stopped recommending it.

Back then,this group was telling people that if they couldn't find the pills to use fishtank cleaner, when that story came out I wondered if it was a case of murder.

109 posted on 01/07/2024 3:19:53 PM PST by LadyDoc (liberals only love politically correct poor people)
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To: RummyChick

For any of you that have dogs that can’t take Ivermectin because of their gentic issue ( such as border collies) the same thing can play out in humans with a genetic defect in the gene that helps maintain the blood/brain barrier.

It can cause neuro toxic issues in humans.

I maintain that given how hard it was for me to discover my genetic drug issues...there are going to be many here who have them but just dont know it yet..and may never now it if they dont get thorough genetic testing.

I have had “official” testing where they don’t test you for as many variants and unofficial testing that tests for emerging variants.

NONE of my regular Doctors know jack about the issue other than they have heard of P450. LOLOLOL


110 posted on 01/07/2024 3:20:50 PM PST by RummyChick
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To: nickcarraway

I was in research for 30 years. The FIRST question on any study, report, etc. that has to be answered is who sponsored the study? Who paid for it? Do/did the researchers have any other contracts, grants studies or funds that depend on the particular outcome this current study relates? What are the political affiliations of the researchers involved?

I find it odd....or some other word...that ‘meta-analysis’ of some data can squeeze out the death factor of a drug so precisely yet we don’t even have decent tests or data or proof that there is nothing wrong with the Covid Vaxxines.


111 posted on 01/07/2024 3:22:17 PM PST by Gaffer
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To: nickcarraway

But let’s not talk about 17 million who died from the vaccines - I serious doubt this report on 17,000


112 posted on 01/07/2024 3:23:28 PM PST by revivaljoe ( )
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To: nickcarraway

Is it true that the large majority of COVID deaths were obese?


113 posted on 01/07/2024 3:25:00 PM PST by Theodore R. ( )
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To: cpdiii
"HCQ has been administered literally billions of times in the tropics for prevention of malaria."

Bears repeating..

114 posted on 01/07/2024 3:26:37 PM PST by unread (I pledge allegiance to the flag of the United States of America, and to the REPUBLIC..!)
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To: RummyChick
said, "Quercetin is a multiple P450 inhibitor."

i can't find any information showing this. That seems backward from how it functions. I doubt this part.

"Quercetin is also P-gp inhibitor"
Again i can't find any information on this. Though i do know it effects ATP production. Which p-gp inhibitor would do. good offset for that is Melatonin.

Either way if this is true or not Quercetin and HCQ should NOT be used as a preventative. only when you have symptoms. I can list many issues that has negative effects which shows they should not be used on a regular bases.

known inhibitors of P-glycoprotein (P-gp)
https://www.uptodate.com/contents/image?imageKey=EM%2F73326
P450 3A (including 3A4) inhibitors
https://www.uptodate.com/contents/image?imageKey=CARD%2F76992
115 posted on 01/07/2024 3:26:37 PM PST by Steve Van Doorn
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To: Jonty30

Jonty30 wrote: “Maybe many of us did and determined that the vaccine wasnt going to save anybody and it’s only function was to make Fauci $30 million and the Big Pharma $100 billion in profit?”

You determined wrong. The vaccines saved millions of lives.


116 posted on 01/07/2024 3:31:19 PM PST by DugwayDuke (Most pick the expert who says the things they agree with.)
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To: Steve Van Doorn

There is at least one study that looked at P450 issues in COVID sufferers admitted to the hospital. I can’t remember the title of the study and can’t find it at the moment.

They were finding a link between severe sufferers who didnt respond to HCQ treatment and genetic P450 issues.

I need to try to track down that study to look at it again.

It probably ended with a statement that further research is needed. I think it theorized that HCQ wasnt as effective in those severe sufferers because the patient didnt get the full value of HCQ due to genetic defects.

Of course, what about the people who have no defect and still didn’t benefit. Most people have not had a whole genome test of their body. And even if they do access to all their variants (like I do) so much is still in the emerging category.


117 posted on 01/07/2024 3:32:14 PM PST by RummyChick
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To: LadyDoc
In the paper cited below the authors studied 31 randomized controlled studies with HCQ (1996 - 2022), 9 studies using Chloroquine and 1 study using both HCQ and CQ. There were no reports on torsades de pointes or sudden cardiac death. Risk of severe cardiac events compared wit control (RR) was 0,90 (ie nominally less risk with HCQ/CQ) but no statistical significance.

Despite being listed as QT-prolonging meds, HCQ-CQ did not increase the risk of major adverse cardiac events.

Hydroxychloroquine-Chloroquine, QT-Prolongation, and Major Adverse Cardiac Events: A Meta-analysis and Scoping Review

118 posted on 01/07/2024 3:32:15 PM PST by ScaniaBoy (Part of the Right Wing Research & Attack Machine)
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To: Steve Van Doorn

Look at the Flockhart table for starters.


119 posted on 01/07/2024 3:33:12 PM PST by RummyChick
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To: nickcarraway

“The drug was found in particular to cause severe side effects such as heart rhythm abnormalities.”

“Hydroxychloroquine was approved for medical use in the United States in 1955. It is on the World Health Organization’s List of Essential Medicines. In 2020, it was the 126th most commonly prescribed medication in the United States, with 4.99 million prescriptions.”

One of the most prescribed drugs in world history, used for many things, including malaria.

They are lying, in that pencillin, a great blessing to mankind, has probably killed more than the number cited.


120 posted on 01/07/2024 3:33:23 PM PST by odawg
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