Posted on 02/25/2023 3:38:05 PM PST by ConservativeMind
Psyllium fiber protects against ulcerative colitis and suppresses inflammation by activating the bile acid nuclear receptor, a mechanism that was previously unrecognized, according to a study.
The findings reveal that psyllium inhibits inflammation that can lead to colitis in mice by increasing serum bile acids, resulting in the activation of the farnesoid X receptor (FXR), a bile acid nuclear receptor.
Fiber-rich foods promote intestinal and metabolic health, but the extent of protection varies for each fiber type. It has been unclear whether dietary fiber can benefit severe forms of intestinal inflammation, such as Crohn's disease and ulcerative colitis, which are collectively known as inflammatory bowel disease (IBD).
This study was designed to identify specific fibers that might protect mice in two models of experimental colitis. The study also investigated the mechanism by which protective fibers might suppress inflammation.
Several fibers were tested, including inulin, cellulose, pectin, glucomannan and psyllium. The authors found psyllium has the unique ability to improve two chronic inflammatory states: metabolic syndrome and colitis.
"The results were impressive in that even modest amounts of psyllium provided strong protection in both colitis models," said Andrew Gewirtz.
"That psyllium can offer protection against colitis fits with limited human studies that psyllium is effective in maintaining remission of ulcerative colitis, but its mechanism of action was largely unknown," added Alexis Bretinz
Psyllium led to an increase in bile acids that resulted in activation of the FXR bile acid receptor. Such FXR activation was necessary and sufficient to prevent colitis. This suggests that pharmacologic FXR activation might be useful in managing IBD.
"There has been a lack of consensus on the impact of dietary fiber on IBD, and the notion that soluble/fermentable fibers might negatively impact IBD has prompted many patients to consume low-fiber diets," Gewirtz said.
(Excerpt) Read more at medicalxpress.com ...
With the colon hobbled by any of the diseases mentioned, I can certainly see why it would help pass the fecal matter.
With so many people affected by these diseases, one wonders why science hasn’t been able to come up with a cure or at least a medicine that would force it back into remission.
I’m surprise low dose steroids isn’t used more often than it is to give the patient longer lasting relief. I bet most patients would prefer it along with any side effects to the obvious pain, symptoms, and general discomfort of any of the IBD diseases that make them a prisoner in their homes.
The write up says it put colitis into remission…
Psyllium fiber works wonders. Makes me feel 30 years younger when I sit on the porcelain furniture.
The meds they put me on for my colitis works really well. I have been in remission for years. Azathiopine
“Psyllium fiber works wonders.”
Agree. About 10 years ago one person on Amazon wrote a review of some of the psyllium capsules, and it was so funny. The reviewer said that he had “found the Holy Grail of bowel movements”. That was when it was possible to comment on the reviews. And his review was a big hit.
I found a Two-part study that describes several types of digestive fiber. I will list the URL’s here-
Part 1: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415962/
Part 2: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415970/
I hope this helps!
Azathiopine. Asacol. Prednisone. People who suffer from colitis, like people who suffer from back pain, must try everything. Resveratrol works, too, along with prayer and sleep. Colitis is an inflammation.
Frankincense (Boswellia Serrata) nails most all ulcerative disorders.
Been around for thousands of years. Few side effects. Inexpensive and you don’t need to keep taking it once you’re healed…. Boohoo big pharma
Yeah for the poop shoot !
The purpose of modern medicine, in cahoots with Big Pharma, is NOT to cure, but to sell pharmaceuticals.
If you have UC, you have no trouble passing fecal matter. Once the stool hits an ulcer, it goes out fast.
That stuff rocks!
Difficult to talk others into trying it...
What kind do you use
I wish that claim were true.
What brand
I buy Metamucil in cinnamon snack treats. While I can’t vouch for its benefits as a fiber,it’s nice to have when needing a snack.
I’m glad it’s working for you. Every ‘body’ is different so nothing works for 100% of the people. It looks like your meds work for about 49% so that’s pretty good.
Looks like it's for external use only. How does that help?
Just eat steel cut oats in the morning. They give you all the fiber you need. JMO
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