Any one care to put that medical science speak into simple English?
Do you understand any of this?
Have not read this yet but am betting bad lipid fats from polyunsaturated vegetable oils are involved.
I am not a doctor but it sure sounds good to me.
J Biol Chem . 2005 Feb 18;280(7):5892-901. doi: 10.1074/jbc.M404751200. Epub 2004 Dec 7.
https://pubmed.ncbi.nlm.nih.gov/15590663/
Abstract
"Alzheimer's disease (AD) involves amyloid beta (Abeta) accumulation, oxidative damage, and inflammation, and risk is reduced with increased antioxidant and anti-inflammatory consumption. The phenolic yellow curry pigment curcumin has potent anti-inflammatory and antioxidant activities and can suppress oxidative damage, inflammation, cognitive deficits, and amyloid accumulation. Since the molecular structure of curcumin suggested potential Abeta binding, we investigated whether its efficacy in AD models could be explained by effects on Abeta aggregation. Under aggregating conditions in vitro, curcumin inhibited aggregation (IC(50) = 0.8 microM) as well as disaggregated fibrillar Abeta40 (IC(50) = 1 microM), indicating favorable stoichiometry for inhibition. Curcumin was a better Abeta40 aggregation inhibitor than ibuprofen and naproxen, and prevented Abeta42 oligomer formation and toxicity between 0.1 and 1.0 microM. Under EM, curcumin decreased dose dependently Abeta fibril formation beginning with 0.125 microM. The effects of curcumin did not depend on Abeta sequence but on fibril-related conformation. AD and Tg2576 mice brain sections incubated with curcumin revealed preferential labeling of amyloid plaques. In vivo studies showed that curcumin injected peripherally into aged Tg mice crossed the blood-brain barrier and bound plaques. When fed to aged Tg2576 mice with advanced amyloid accumulation, curcumin labeled plaques and reduced amyloid levels and plaque burden. Hence, curcumin directly binds small beta-amyloid species to block aggregation and fibril formation in vitro and in vivo. These data suggest that low dose curcumin effectively disaggregates Abeta as well as prevents fibril and oligomer formation, supporting the rationale for curcumin use in clinical trials preventing or treating AD." ---------------------------------------------------------------------------------------------------------------------------------
I ran across a mention turmeric/curcumin while reading "Memory Loss is not Inevitable" by Allen S Josephs, M.D. A fairly short 94 pages.
(He is a Board Certified Physican with internal medicine and neurology accreditations Previous Section Chief of nerology St Barnabas Medical Center Livinston NJ.)
India (reportedly) uses tumeric (source of curcumin) extensively in its cooking and has (reportedly) a low rate of Alzheimers.
Seems like a cheap and easy enough to incorporate in your diet pending the inevitable high cost pharmaceutical solution. Turmeric was discussed on Page 87 of the book.
I would recommend this book for anyone who has a relative who may be starting to have memory problems. (Or if you are worried at your own situation!)
Thanks for posting! We have a national problem with alzheimers right now!
The right diet is pretty much protection against anything.
https://www.endalznow.org/news/research-shows-intermittent-fasting-may-prevent-alzheimers-disease
We need this process, but it appears to have become dysfunctional in Alzheimer's patients.
I come back, again and again, to the gradual, imperceptual changes a bad diet gives each of us. We may gain weight, or have additional issues inside, which we chalk up to “getting older,” when it was from multiple daily insults to our bodies which we did not overcome.
I think they are doing their research in a fashion where they are trying to find a drug to patent. This is not really useful in my eyes. The reality is that Alzheimer’s is both genetically and habitually predictable. In other words you can figure out if you are at risk by looking at your siblings and other family members who are older. If they got it, you are more likely. In my family, every single female on my fathers side (a very large family) has died of Alzheimer’s. And secondly, you can look at those with fatty liver or diabetes 2. They are far more likely to get Alzheimer’s.
Alzheimer’s is a condition where avoidance is far better than a cure. The rate of Alzheimer’s has increased around the world as people start eating the Standard American Diet.
Given that, try not to contract fatty liver. That means staying away from Fructose, maybe alcohol and carbs. High Fructose Corn Starch was the most common way to ingest fructose for the past 40 years. Also fruit juices are very high in fructose.
These researchers are trying to let you eat wrong, get fat, continue your horribly unhealthy life style and take a pill that allows you to avoid Alzheimer’s but get your knees replaced and stay on numerous other pills designed to keep the unhealthy alive.
bookmark
I’d like to get rid of a pound or two..
Orange Amyloid Bad.
BTTT
My father in law died of Alzheimer’s. My wife would be interested in this article, but she just recently passed away also.
Is that J.B.’s brain?
p
PING !
Who’d a thunk it
That image looks like a Dali painting.