Do you understand any of this?
Only Some, but by no means all.....................
I think it’s about Alzheimer’s Disease.
Dr. Tanzi has had the most significant Alz discoveries so far and if his lab says he has a breakthrough this is very good news. He is also an interesting man. This article states that Tanzi believes he knows how AB is formed in the brain. AB “may” be important as the cause of Alz formation. By knowing the AB trigger this could lead to future treatments...there is currently no successful treatment for ALZ (regardless of the recent approval by the FDA of an ALZ treatment.)Please accept that my description is written by a layman
Researchers want to figure out how to block a key protein called the sigma-1 receptor (S1R) from acting to create amaloid plaque in the brain.
----------------------------------------------------------------------------------------------------------------------- a bit longer version.
Researchers around the world have worked intensely to find ways to block the formation of amyloid beta by preventing cleavage by beta secretase and gamma secretase. However, these approaches have been hampered by safety issues.
a form of APP that has undergone a process called palmitoylation (palAPP) gives rise to amyloid beta.
The new investigation revealed that palAPP is stabilized and prepared for cleavage by beta secretase in special lipid rafts within the neuron known as mitochondria-associated endoplasmic reticulum membranes (MAMs). “We showed for the first time not only that the MAM is where palAPP is processed by beta secretase to make Abeta, but that this happens exclusively in axons and neuronal processes where Abeta does most of its damage,”
They showed for the first time that preventing assembly of MAMs, either with gene therapy or a drug that blocked a key protein called the sigma-1 receptor (S1R), dramatically decreased beta secretase cleavage of palAPP in axons and lowered Abeta production.
(and therefore Amloid plaque.)
Until they figure this out use Turmeric and fish oil!