Researchers want to figure out how to block a key protein called the sigma-1 receptor (S1R) from acting to create amaloid plaque in the brain.
----------------------------------------------------------------------------------------------------------------------- a bit longer version.
Researchers around the world have worked intensely to find ways to block the formation of amyloid beta by preventing cleavage by beta secretase and gamma secretase. However, these approaches have been hampered by safety issues.
a form of APP that has undergone a process called palmitoylation (palAPP) gives rise to amyloid beta.
The new investigation revealed that palAPP is stabilized and prepared for cleavage by beta secretase in special lipid rafts within the neuron known as mitochondria-associated endoplasmic reticulum membranes (MAMs). “We showed for the first time not only that the MAM is where palAPP is processed by beta secretase to make Abeta, but that this happens exclusively in axons and neuronal processes where Abeta does most of its damage,”
They showed for the first time that preventing assembly of MAMs, either with gene therapy or a drug that blocked a key protein called the sigma-1 receptor (S1R), dramatically decreased beta secretase cleavage of palAPP in axons and lowered Abeta production.
(and therefore Amloid plaque.)
Until they figure this out use Turmeric and fish oil!
Oh good, you’re here. I have not a single solitary clue what any of this means.
I think I’ll go make golden milk with turmeric now.