Any one care to put that medical science speak into simple English?
Stay away from oranges.
Not a doctor, but it looks like they now have a good idea about how harmful, brain-damaging proteins form and this could eventually lead to effective treatments.
“Any one care to put that medical science speak into simple English?”
Sure:
“...guidepost for developing new therapies...”
Translated:
We found a way to make money off of a drug which you must take to prevent the buildup of plaque, but you’re too dumb to understand that we’re taking advantage of you and withholding the information you need to prevent Alzheimer’s without our drugs.
It’s the next ‘statin’ drug, doncha know.
They discovered the mechanism by which the proteins form that cause Alzheimer’s. This should lead to therapeutics in the form of gene therapies or pills/shots that could counteract that process.
As with anything, I’m sure they’re going to test the snot out of their hypotheses, sort of like how science is supposed to work, but I don’t expect we’ll see anything for human trials for another 3-5 years.
“Any one care to put that medical science speak into simple English?”
Need a therapy to clean the gunk causing alzheimers off of the nerve endings.
Here’s the bottom line. The cell organelle that makes the protein that destroys neurons is controlled by an enzyme known as SIGMAR-1. Increase SIGMAR-1 blocks a critical receptor and the toxic protein is blocked from production. Healthy people produce SIGMAR-1 most of their life but it declines with age and severely declines with Alzheimer’s patients.
Currently the leading drug candidate that does exactly this is Anavex Lifesciences AVX-273 clinical trial.
Yeah. Start eating keto, and take it seriously. Every day.
No sugar, no carbs, no alcohol,
Get your weight within guidelines. Then lose 10% more.
Do your own research.
Eat and drink like an idiot and get Alzheimer’s, diabetes, heart disease, debilitating arthritis, kidney failure, etc, OR take your nutrition seriously and live 20 years longer, or more.
Jesus is Lord.
Big patented drug sales potential!
I’ll put it in simple English for you. Wait . . . what was I saying?
“Any one care to put that medical science speak into simple English?”
They have identified the details of specific steps that occur, in producing the gunk that builds up in brains with Alzheimer’s. They also showed that by blocking one specific step, it would block production of that gunk.
However, that does not necessarily mean that blocking the gunk buildup, will prevent mental decline. Others have reduced the gunk, without reversing the mental decline.
In addition to the buildup of this gunk (Amyloid Beta), there is also a tangling that occurs among brain cells during Alzheimer’s, and inflammatory effects. It is possible that the gunk is just a secondary effect (symptom) of Alzheimer’s, and not the cause.
It was good, detailed research, that convincingly detailed some of the processes involved. So it is a significant step forward in understanding Alzheimer’s - but it is still a long way from a cure, and has not been shown to prevent it.
“Any one care to put that medical science speak into simple English?”
Alzheimer’s is caused by a neurotoxin
They figured out how one possible cause of Az is created and attaches itself to the brain. They can now focus on stopping that process. This is only one possible Az cause, so it is a breakthrough but much more...hey, did I tell you about my new dog?
Yet every medical treatment to reduce amyloid beta fails to stop or slow down AD. Amyloid beta is the body's attempt to heal AD.
Amyloid Beta, when injected into mice with multiple sclerosis, heals the mice of MS within two weeks. This has been known for 8 years, yet there has been no attempt to try it on humans. (no profit).
And if there’s a way to prevent it?
Eat crappy food (old people love buffets ) and live long enough your brain turns to crap. Well I’m biased.