Posted on 10/18/2021 7:48:32 AM PDT by Red Badger
Any one care to put that medical science speak into simple English?
Do you understand any of this?
Stay away from oranges.
Only Some, but by no means all.....................
G
Not a doctor, but it looks like they now have a good idea about how harmful, brain-damaging proteins form and this could eventually lead to effective treatments.
I think it’s about Alzheimer’s Disease.
“Any one care to put that medical science speak into simple English?”
Sure:
“...guidepost for developing new therapies...”
Translated:
We found a way to make money off of a drug which you must take to prevent the buildup of plaque, but you’re too dumb to understand that we’re taking advantage of you and withholding the information you need to prevent Alzheimer’s without our drugs.
It’s the next ‘statin’ drug, doncha know.
They discovered the mechanism by which the proteins form that cause Alzheimer’s. This should lead to therapeutics in the form of gene therapies or pills/shots that could counteract that process.
As with anything, I’m sure they’re going to test the snot out of their hypotheses, sort of like how science is supposed to work, but I don’t expect we’ll see anything for human trials for another 3-5 years.
Have not read this yet but am betting bad lipid fats from polyunsaturated vegetable oils are involved.
I am not a doctor but it sure sounds good to me.
J Biol Chem . 2005 Feb 18;280(7):5892-901. doi: 10.1074/jbc.M404751200. Epub 2004 Dec 7.
https://pubmed.ncbi.nlm.nih.gov/15590663/
Abstract
"Alzheimer's disease (AD) involves amyloid beta (Abeta) accumulation, oxidative damage, and inflammation, and risk is reduced with increased antioxidant and anti-inflammatory consumption. The phenolic yellow curry pigment curcumin has potent anti-inflammatory and antioxidant activities and can suppress oxidative damage, inflammation, cognitive deficits, and amyloid accumulation. Since the molecular structure of curcumin suggested potential Abeta binding, we investigated whether its efficacy in AD models could be explained by effects on Abeta aggregation. Under aggregating conditions in vitro, curcumin inhibited aggregation (IC(50) = 0.8 microM) as well as disaggregated fibrillar Abeta40 (IC(50) = 1 microM), indicating favorable stoichiometry for inhibition. Curcumin was a better Abeta40 aggregation inhibitor than ibuprofen and naproxen, and prevented Abeta42 oligomer formation and toxicity between 0.1 and 1.0 microM. Under EM, curcumin decreased dose dependently Abeta fibril formation beginning with 0.125 microM. The effects of curcumin did not depend on Abeta sequence but on fibril-related conformation. AD and Tg2576 mice brain sections incubated with curcumin revealed preferential labeling of amyloid plaques. In vivo studies showed that curcumin injected peripherally into aged Tg mice crossed the blood-brain barrier and bound plaques. When fed to aged Tg2576 mice with advanced amyloid accumulation, curcumin labeled plaques and reduced amyloid levels and plaque burden. Hence, curcumin directly binds small beta-amyloid species to block aggregation and fibril formation in vitro and in vivo. These data suggest that low dose curcumin effectively disaggregates Abeta as well as prevents fibril and oligomer formation, supporting the rationale for curcumin use in clinical trials preventing or treating AD." ---------------------------------------------------------------------------------------------------------------------------------
I ran across a mention turmeric/curcumin while reading "Memory Loss is not Inevitable" by Allen S Josephs, M.D. A fairly short 94 pages.
(He is a Board Certified Physican with internal medicine and neurology accreditations Previous Section Chief of nerology St Barnabas Medical Center Livinston NJ.)
India (reportedly) uses tumeric (source of curcumin) extensively in its cooking and has (reportedly) a low rate of Alzheimers.
Seems like a cheap and easy enough to incorporate in your diet pending the inevitable high cost pharmaceutical solution. Turmeric was discussed on Page 87 of the book.
I would recommend this book for anyone who has a relative who may be starting to have memory problems. (Or if you are worried at your own situation!)
And hydrogenated oils?
Dr. Tanzi has had the most significant Alz discoveries so far and if his lab says he has a breakthrough this is very good news. He is also an interesting man. This article states that Tanzi believes he knows how AB is formed in the brain. AB “may” be important as the cause of Alz formation. By knowing the AB trigger this could lead to future treatments...there is currently no successful treatment for ALZ (regardless of the recent approval by the FDA of an ALZ treatment.)Please accept that my description is written by a layman
Thanks for posting! We have a national problem with alzheimers right now!
One thing it isn't is that for anyone dealing with Alzeimer's in their home or life it doesn't make a very damn good joke.
Yup, either or both. Bad lipids.
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