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C is for Vitamin C -- a key ingredient for immune cell function (Required for fighting autoimmune issues)
Science Daily / La Jolla Institute for Immunology / EMBO reports ^ | July 21, 2021 | Xiaojing Yue, Daniela Samaniego‐Castruita, Edahí González‐Avalos, Xiang Li, Benjamin G Barwick, Anja

Posted on 07/23/2021 4:39:27 PM PDT by ConservativeMind

You can't make a banana split without bananas. And you can't generate stable regulatory T cells without Vitamin C or enzymes called TET proteins, it appears.

Regulatory T cells (Tregs) help control inflammation and autoimmunity in the body. Tregs are so important, in fact, that scientists are working to generate stable induced Tregs (iTregs) in vitro for use as treatments for autoimmune diseases as well as rejection to transplanted organs. Unfortunately, it has proven difficult to find the right molecular ingredients to induce stable iTregs.

In their analysis, the researchers found TET proteins are absolutely required for maintaining the gene expression and epigenetic features that make Tregs as what they are; and adding Vitamin C led to iTregs with similar similar gene expression and epigenetic features as normal "wild type" Tregs found in the body. The study also reveals an intriguing connection between TET enzymatic activity, Vitamin C and IL-2/STAT5 signaling.

"In mice that are deficient for components of IL-2/STAT5 signaling, such as IL-2, IL-2 receptors or STAT5, the Tregs cannot develop properly or they can have impaired function," Yue says.

The researchers demonstrate that on one hand, TET-deficiency in Treg cells leads to impaired IL-2/STAT5 signaling; on the other hand, Vitamin C confers iTregs enhanced IL-2/STAT5 signaling by increasing the expression level of IL-2 receptor and the functional form of STAT5, and STAT5 binding to essential regions in the genome, rendering these cells survive better in tough environments with low IL-2 supplementation.

(Excerpt) Read more at sciencedaily.com ...


TOPICS: Health/Medicine
KEYWORDS: autoimmunedisease; dsj03; immunesystem; vitc
Tregs (Regulatory T cells) both prevent autoimmune disorders and tamp down an already present one. Vitamin C seems required to create them, possibly at several levels. Vitamin C is best absorbed in a time-release form, as we excrete it in a couple hours.

Another way to help is to take 1/4 to 1/2 a teaspoon of baking soda a day for two weeks, with which the following study shows our bodies start making more Tregs.

1 posted on 07/23/2021 4:39:27 PM PDT by ConservativeMind
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To: ConservativeMind
Baking soda helps body make Tregs:

https://www.jimmunol.org/content/200/10/3568

2 posted on 07/23/2021 4:40:07 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I drink a 12 oz glass of OJ every day.


3 posted on 07/23/2021 4:46:40 PM PDT by EvilCapitalist (I voted for prosperity, and I got poverty.)
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To: ConservativeMind

Fauci takes Vit C & D....but he sure didn’t promote something so simple. Just take a multiple vit...what you use, you use...what you don’t goes in “the bowl”.


4 posted on 07/23/2021 4:50:50 PM PDT by Sacajaweau
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To: Sacajaweau

Just take a multiple vit...what you use, you use...what you don’t goes in “the bowl”.


Excess vitamin A is a common problem. The vitamin A you don’t use is stored in the liver. It eventually creates bone problems.


5 posted on 07/23/2021 4:59:56 PM PDT by TTFX ( )
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To: ConservativeMind

Which only works if you are not allergic to vitamin C.

I’m still trying to find one that doesn’t cause me to break out all over.


6 posted on 07/23/2021 5:24:46 PM PDT by metmom (...fixing our eyes on Jesus, the Author and Perfecter of our faith…)
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To: metmom

Wow, I hadn’t heard of this until you mentioned it.

https://www.livestrong.com/article/485015-ascorbic-acid-vitamin-c-allergies/

It does say non-supplement forms should be fine.

Natural forms:
https://www.healthline.com/nutrition/vitamin-c-foods

Also hibiscus tea:
https://www.doctorshealthpress.com/food-and-nutrition-articles/hibiscus-tea-benefits/

Metmom, I’m sorry you have this.


7 posted on 07/23/2021 5:34:48 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

C is one of the water soluble vitamins, which is why it is quickly eliminated. The way around this is to take what is called “Liposomal” Vitamin C, which is fat soluble. Not only is it retained much longer, but it also penetrates the cell wall better. It can be purchased online.


8 posted on 07/23/2021 5:40:34 PM PDT by yefragetuwrabrumuy (Do kids in Iceland still play "The Floor Is Lava?")
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To: ConservativeMind

“All your immunity are belong to us.”

We gave everybody with aids through the mrna spike protein injections.

No vitamin c. No hydroxychloroquine. No ivermectin. Banned.

Immunity is now pay to play.

Now worship Beast, slave.

9 posted on 07/23/2021 5:55:56 PM PDT by conservativeimage (The mask is the boot stamping on the human face forever.)
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To: ConservativeMind

The article does not give any recommendations regarding how much (i.e., how many mg. ) of Vitamin C the average person should take.


10 posted on 07/23/2021 6:21:21 PM PDT by SeekAndFind
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To: SeekAndFind

That is true. I would suggest taking something is better than nothing for this purpose.

ConsumerLab.com says 50-100 mg a day is the minimum we need, with any daily amount over 500 mg to 2,000 mg a day for colds, gout, high blood pressure, etc, increasing the risk of cataracts, according to studies.

https://www.consumerlab.com/reviews/vitamin-c-supplement-review/vitaminc/


11 posted on 07/23/2021 6:36:25 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: SeekAndFind

From the vitamin C information, I’d say 500 mg a day, time release, would be the happy compromise.


12 posted on 07/23/2021 6:38:11 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: SeekAndFind

“how many mg. ) of Vitamin C the average person should take.

Dr Linus Pauling, wo wrote the book on Vit C said you can’t take too much. I have been taking Vit C with Rose Hips for many years and I have never had to flu or even a cold. I take 2000 mil now because of covid. I take all the other recommended vitamins. D3, B12, Zink. I’ve stayed healthy so far (87).


13 posted on 07/23/2021 6:41:27 PM PDT by WVNan (neve)
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To: Sacajaweau

Excellent point. When I was undergoing wound therapy several years back, the doctor treating me was also a specialist in this sort of thing. He’d described pictures taken at municipal waste treatment plants, where they separated various types of solid waste from the water, not just your ‘leavings’ but other organic/inorganic detrius. He said that huge piles of OTC meds were sifted out, much of it in the form of pills people take, and one of the big ones was vitamins. He told me that they didn’t completely digest in your digestive tract, so much of the nutrient value flushes out of the body. He espoused either liquicaps, which dissolve almost immediately upon hitting the stomach, or gummies, which are semi-digested while you’re chewing them. I’ve been a gummie advocate ever since. Thanks.


14 posted on 07/23/2021 6:48:27 PM PDT by Viking2002 (Remember, all the world’s a barstool.)
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To: ConservativeMind

I can’t even think of touching high vitamin C fruits or veggies anymore.

Used to be I’d just break out bad with eczema.

But now it seems to have gone internal and my whole digestive system feels like it’s on fire.

I think it’s the histamine that is causing the burning.


15 posted on 07/23/2021 6:53:14 PM PDT by metmom (...fixing our eyes on Jesus, the Author and Perfecter of our faith…)
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To: metmom
Protocol for recovery from Vitamin C allergy:
https://journals.ku.edu/kjm/article/view/8617/8121

Liposomal Vitamin C:
https://draxe.com/nutrition/liposomal-vitamin-c/

Liposomal Vitamin C may be up to 70x more absorbable (or take 1/70-seems too good to be true, but study reference is given):
https://www.amandean.com/blogs/news/liposomal-vitamin-c-and-allergies-what-is-the-connection

Liposomal Vitamin C bypasses several conversion steps which might have problems:

“Because they bypass the normal mechanism of absorbing vitamin C through slow vitamin C receptors type 1 (sodium-dependent vitamin C receptors SCVT 1), the bioavailability is much higher than standard vitamin C supplements.”

https://coremedscience.com/blogs/wellness/how-to-pick-the-best-liposomal-vitamin-c

16 posted on 07/23/2021 7:24:55 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: nutmeg

.


17 posted on 07/23/2021 7:28:07 PM PDT by nutmeg (God bless you and thank you, Rush)
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To: metmom

Please take a look at the baking soda study referenced above (1/4 teaspoon a day for two weeks made the spleen encourage Treg cells that subdued all sorts of inflammation).

Of course, lower Omega-6 fats, increase Omega-3 fats, take vitamin D3, and antioxidants to further reduce inflammatory responses. There are other things to do the same, as well.

I have to believe there are ways to help turn this around, Metmom.


18 posted on 07/23/2021 7:31:09 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Bkmk


19 posted on 07/23/2021 10:16:23 PM PDT by kelly4c
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To: yefragetuwrabrumuy

I was taking liposomal vitamin c because I thought the same way. I was listening to Dr. Marik and Dr. Kory of FLCCC fame and during the Q&A section of this week’s podcast/video, one of them said liposomal isn’t more effective….as the lipid shell gets broken down in the gut and that limits uptake just like normal oral vitamin c.

I haven’t researched it yet but Dr. Marik would know his vitamin C since he pioneered using IV vitamin c for the treatment of sepsis.


20 posted on 07/24/2021 7:15:22 AM PDT by June2
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