Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid

Nutrients Journal ^ | 2018 Nov 14 | Paul E. Marik

[ConservativeMind]

Abstract

Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid and Thiamine (HAT therapy) may reduce organ failure and mortality in patients with sepsis and septic shock. HAT therapy is based on the concept that a combination of readily available, safe and cheap agents, which target multiple components of the host’s response to an infectious agent, will synergistically restore the dysregulated immune response and thereby prevent organ failure and death. This paper reviews the rationale for HAT therapy with a focus on vitamin C.

(Snip)

Conclusions

Glucocorticoids, vitamin C and thiamine have important biological effects in patients with sepsis and septic shock. Due to the overlapping and synergistic effects of these remarkably safe and inexpensive drugs, the combination of these agents (HAT therapy) likely restores the dysregulated immune system and bioenergetic failure that characterizes sepsis. We, therefore, propose that HAT therapy will improve both the short-term (mortality) and long-term (post-sepsis syndrome) outcome of patients with sepsis and septic shock. Multiple randomized controlled trials are currently underway to test this hypothesis

[Hot Tabasco]

I suppose you trust all car salesmen and mechanics, too.

I see the direction you're trying to take this and based on your comment, it's not even worth discussing it anymore.........

Have a Merry Christmas........

[ConservativeMind]

I completely draw a parallel between auto mechanics and doctors.

That’s also parallel with the doctor experience I described.

The extra tests and procedures for no reason is just like a replaced fuel pump that was actually okay.

[ocrp1982]

“I have a family of physicians” so, you have a familial bias. The experience detailed by a previous poster is not invalidated because you have a family of physicians.
Not all physicians are equal.
Many are, as another poster stated “on auto-pilot” they parrot what a pharmaceutical company told them about the drugs they prescribe. Parrot what they were told in Med School, etc...
They see far too many patients for a very short length of time. Book more patient visits than they can accommodate in the time frame causing patients to spend far more time in a waiting room than they ever give those same patients in the evaluation room.
Does this describe every doctor? No. But, it describes the majority of them.
Too many “doctors” do not bother to keep up with research, pro and con to their prescribed notions of how to treat X,Y, or Z apparent condition.

[matthew fuller]

Primal Panacea Paperback – THX, January 1, 2011
by Thomas E. Levy (Author), Garry Gordon (Foreword)
4.8 out of 5 stars 127 ratings

The price of this paperback is headed upwards now. Dr. Levy MD, JD suggests useing Vit C orally and intravenously to cure many things. I recommend this book.

[TChad]

There’s no money in it, therefore it will be ignored.

Not if it works. If you insist on a financial motive, doctors make more money if they avoid malpractice suits.

[Texan]

I'm printing this out. In the last few years my husband has had sepsis 5 times. After the first time, I recognize the symptoms and get him to the emergency room fast. Then it's almost a week in the hospital and another 10 days of IV antibiotics at home. He's become drug resistant and down to only a few that will work.

Thanks for the article.

[GnuThere]

I’ve read about this protocol on Dr. Mercola’s website.
I wish intensivists/ critical care specialists would embrace it, but in the time one could spend advocating it, you’d be dead.

[newzjunkey]

My mother (a fellow freepers) died from it. They had diagnosed her with pneumonia.

[Qiviut]

Check this out for flu (& it’s in what I would call a ‘reputable’ source):

Vitamin D for influenza
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463890/

Whole thing is interesting, but the last paragraph has clinical observations from an actual practice (which is something I like to see) & references the “Vitamin D hammer”. If I come down with the flu, definitely going to try this & I’m being diligent about keeping my Vit D levels in good shape.

[ConservativeMind]

I have nothing against your family.

Merry Christmas my brother FReeper!

[Jayster]

Lypo-Spheric Vitamin C - 30... https://www.amazon.com/dp/B000CD9XGC?ref=ppx_pop_mob_ap_share

[ConservativeMind]

I have bookmarked that.

Very interesting and brief!

[ConservativeMind]

You might want to get him on a time release Vitamin C and a Thiamine supplement of some sort. It might prevent the next occasion.

[Mom MD]

there are a lot of things that initially look promising that turn out not to be so or even are harmful. Steroids (hydrocortisone) have been debated in sepsis for the 35 years i have been practicing medicine and fallen in and out of favor. Several years ago it was activated protein C (xigris) with the apache trial that was going to save everyone with sepsis. it actually turned out it was harmful. By all means read studies and become informed but also realize it takes years of experience and seeing things come and go to put some of these things in the proper perspective.

[Mom MD]

actually the fluid of choice is now ringers lactate not saline.

[Mom MD]

don’t do that we are all miserable rotten scoundrels that are in it for the $ and don’t care who we hurt according to some on this site. Why my money grubbing daughter is on call in the icu tonight just so she can make tons of money and kill grandmas..... /s

[Mom MD]

challenge our stupidity and treat your loved ones yourself. You certainly don’t need stupid evil doctors to help you.

[RushIsMyTeddyBear]

I haven’t posted a lot this season since T’giving as my loved one almost died from sepsis and pneumonia. It has been a horrific ride this past month.

[Bob434]

[[Posts like that focus on one event,]]

It’s called ‘anecdotal evidence’ which isn’t scientific at all- like you correctly point out- these are single instances here and there compared to multiple scientific instances that prove otherwise

For instance, someone starts eating say quail eggs, and their warts disappear, so they claim the quail eggs ‘cured their warts’- but the fact is, they added or subtracted all kinds of foods in the meantime, perhaps started eating more healthy, or exercising, or going to the country more, or perhaps htere were changes in their hormones that occurred naturally that somehow combated the warts, or whatever- or maybe their immune system, all on it’s own boosted itself or something- who knows- but because they started eating quail eggs at around the same time their warts dissipated, they attribute hte4 ‘cure’ to the eggs-

As the old saying goes- Correlation doesn’t = Causation- just because someone’s cancer went into remission when they decided to stop all chemo and radiation and concentrate on ‘eating healthy’ doesn’t mean that the ‘eating healthy’ cured their cancer- many people spontaneously go into remission for no apparent reason- and most people who quit chemo and radiation end up dying- despite going to alternative treatment- that is the norm - for every one person who thought they were cured going alternative, science can name 10 who died doing the same thing- (Not sure what the ratio is-)

We had a good friend’s parent die who ignored doctors and went with the ‘natural approach’ ‘alternative approach’ because they viewed ‘Chemo as poison’ - it was tough to watch happen-

[arkfreepdom]

True but the institution of fluid bolus is what I meant. This stuff changes a lot. We used to give steroids. Then told not. Now back again lol