Posted on 06/03/2010 12:09:49 PM PDT by decimon
Results could shed light on origins of various diseases
June 3, 2010 — (BRONX, NY) — Using sophisticated genetic analysis, scientists at Albert Einstein College of Medicine of Yeshiva University and New York University School of Medicine have published a study indicating that Jews are a widely dispersed people with a common ancestry. Jews from different regions of the world were found to share many genetic traits that are distinct from other groups and that date back to ancient times.
The study also provides the first detailed genetic maps of the major Jewish subpopulations, a resource that can be used to study the genetic origins of disease. The findings appear in the June 3 online issue of the American Journal of Human Genetics.
"This study provides new genomic information that can benefit not only those of Jewish ancestry, but the population at large," said co-author Edward Burns, M.D., executive dean and professor of pathology and of medicine at Einstein. "By providing a comprehensive genetic fingerprint of various Jewish subpopulations, it can help us understand genetic links to heart disease, cancer, diabetes and other common diseases."
To better understand the ways in which current Jewish groups are related, Dr. Burns and his colleagues, including principal investigator Harry Ostrer, M.D., professor of pediatrics, pathology and medicine at NYU, performed a genome-wide analysis of the three major groups formed by the Diasporas (the scattering of Jews into Europe, and throughout the Middle East): Eastern European Ashkenazim; Italian, Greek, and Turkish Sephardim; and Iranian, Iraqi, and Syrian Mizrahim Jews.
A total of 237 participants were recruited from Jewish communities in the metropolitan New York region, Seattle, Athens, Rome and Israel. Subjects were included only if all four grandparents came from the same Jewish community. The results were compared with a genetic analysis of 418 people from non-Jewish groups around the world.
The researchers found that Jews from the major Diaspora groups formed a distinct population cluster, albeit one that is closely related to European and Middle Eastern non-Jewish populations. Each of the Diaspora groups also formed its own cluster within the larger Jewish cluster. Further, each group demonstrated Middle-Eastern ancestry and varying degrees of mixing with surrounding populations. The genetic analysis showed that the two major groups, Middle Eastern Jews and European Jews, diverged from each other approximately 2,500 years ago.
"The study supports the idea of a Jewish people linked by a shared genetic history," said Dr. Ostrer of NYU. "Yet the admixture with European people explains why so many European and Syrian Jews have blue eyes and blond hair."
"The goal of the study was to determine a genomic baseline," said lead author Gil Atzmon, Ph.D., assistant professor of medicine and of genetics at Einstein. "With this established, we'll be able to more easily identify genes associated with complex disorders like diabetes that are determined by multiple variants across the genome. Armed with this information, we will be better positioned to treat patients."
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Other investigators who participated in the study include Bernice Morrow, Ph.D., at Einstein; and Eitan Friedman, M.D., Ph.D., at Tel-Aviv University; Li Hao, Christopher Velez, Alexander Pearlman, Ph.D., and Carole Oddoux, Ph.D., at NYU; and Itsik Pe'er, Ph.D., and Pier Francesco Palamara at Columbia University.
The study, "Abraham's Children in the Genome Era: Major Jewish Diaspora Populations Comprise Distinct Genetic Clusters with Shared Middle Eastern Ancestry," was supported by the Lewis and Rachel Rudin Foundation, the Iranian-American Jewish Foundation, the United States-Israel Binational Science Foundation and private donors.
About Albert Einstein College of Medicine of Yeshiva University
Albert Einstein College of Medicine of Yeshiva University is one of the nation's premier centers for research, medical education and clinical investigation. During the 2009-2010 academic year, Einstein is home to 2,775 faculty members, 722 M.D. students, 243 Ph.D. students, 128 students in the combined M.D./Ph.D. program, and approximately 350 postdoctoral research fellows. In 2009, Einstein received more than $155 million in support from the NIH. This includes the funding of major research centers at Einstein in diabetes, cancer, liver disease, and AIDS. Other areas where the College of Medicine is concentrating its efforts include developmental brain research, neuroscience, cardiac disease, and initiatives to reduce and eliminate ethnic and racial health disparities. Through its extensive affiliation network involving five medical centers in the Bronx, Manhattan and Long Island – which includes Montefiore Medical Center, The University Hospital and Academic Medical Center for Einstein – the College of Medicine runs one of the largest post-graduate medical training programs in the United States, offering approximately 150 residency programs to more than 2,500 physicians in training. For more information, please visit www.einstein.yu.edu
Cluster ping.
Sorta junks the old “Khazar” theory, eh?
Prety cool.
They found my family history by following back the evolution of whiskey.
Reading an interesting book now on this pub. 2008
“Jacob’s Legacy: A Genetic View of Jewish History”
by David B. Goldstein
So did they find Abraham’s bones?
Let me guess the “traced” it back to Noah and Shem.
Eve maybe.
What’s so surprising? Isn’t Judaism primarily spread via heredity? In other words, a largely non-proselytising faith.
My relatives on dad’s side traced themselves back to Welshmen who painted their faces blue and howled at the moon.
Duh....
If only ALL faiths can be like this. If you look at the history of "holy wars" they have usually been driven by faiths that proselytize (and I am including communism as a faith here).
The masons stole those.
Wonder how close to Abraham they would be related?
I am told that on one side my ancestry comes from Scotland and along the way a 'full blood' Cherokee woman, but because she was NOT registered on the registry there is NO paper document she was Cherokee.
On the other side my great grandfather stowed away on a ship from Germany in the late 1800's, and I have NO clue if the name he is noted as having is the one he left Germany carrying. There has been no grave site found for him since his death. And I am not sure what bunch he married into once he got here, but I am thinking English.
Now unless Abraham's bones have been discovered I don't see how anybody can claim a lineage to him.
That wish is tantamount to wishing Christianity away. Sure you don't mean that. All of Western civilization which we take for granted today--inalienable rights, equality between men and women, international law, Europe and the west not being islamic--is because of the Christian faith. A great hope in China is the country is being Christianized. Christians are the main force preventing Islam from taking over even more of Africa.
Christians are not about to give up a central tenet of their faith anymore than Jews are. Aside from that, Christianity does not teach conversion by the sword. Not sure to which "holy wars" you refer. The Crusades were defensive, launched centuries after Muslims had raided Rome and sacked the tombs of St. Peter and St. Paul. The European wars of religion in the 16th and 17th century were political events created by the rise of the all powerful state as much as religious and spawned by the break-up of the medieval order (in which their was a balance of power between and among crowns, nobles, the church, merchants and peasants). You will find the "religious wars" were a mixed bag too. Sunni Muslims from Poland fought on the side of Catholics at the gates of Vienna while Protestants from Transylvania were on the side of the Ottoman Turks. Jews allied themselves, at times, with Muslims against the Christian Spanish crown during the Reconquista.
Few people know the history of Islamic invasion of what is now France by the Al-Andulus Muslims in the eighth century. The Franks, led by Charles Martel, defeated the Muslim army at the Battle of Tours in 735 a.d. and spent the next decade pushing them back over the Pyrenees Mountains into what is now Spain. Charles ‘The Hammer’ Martel was the grandfather of Charlemagne.
“genetic links among Jewish people...”? Well duh. If genetic links weren’t there, then that might be newsworthy.
I’m not sure. If the divergence between Middle Eastern and European Jews occurred about 2,500 years ago, then it would seem arguable that the European Jews are descended from the 10 tribes that were carried off by the Assyrians and allegedly scattered into the Caucasus and parts of Central Asia. In any event, it is all interesting.
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