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Antibody finds, wipes out prostate cancer: study
PhysOrg | AFP ^ | 12/28/09

Posted on 12/28/2009 5:35:49 PM PST by LibWhacker

US researchers have found an antibody that hunts down prostate cancer cells in mice and can destroy the killer disease even in an advanced stage, a study showed Monday.

The antibody, called F77, was found to bond more readily with cancerous prostate tissues and cells than with benign tissue and cells, and to promote the death of cancerous tissue, said the study published in the Proceedings of the National Academy of Science (PNAS).

When injected in mice, F77 bonded with tissue where prostate cancer was the primary cancer in almost all cases (97 percent) and in tissue cores where the cancer had metastasized around 85 percent of the time.

It recognized even androgen-independent cancer cells, present when prostate cancer is incurable, the study by researchers at the University of Pennsylvania showed.

F77 "initiated direct cell death of prostate cancer cells... and effectively prevented tumor outgrowth," it said.

But it did not target normal tissue, or tumor tissues in other parts of the body including the colon, kidney, cervix, pancreas, lung, skin or bladder, the study showed.

The antibody "shows promising potential for diagnosis and treatment of prostate cancer, especially for androgen-independent metastatic prostate cancer," which often spreads to the bones and is difficult to treat, the researchers wrote in PNAS.

Currently, the five-year survival rate for metastatic prostate cancer is just 34 percent, according to the study.

Prostate cancer is the second most common cancer among men, claiming half a million lives each year worldwide, according to the World Health Organisation (WHO).


TOPICS: Health/Medicine; Science
KEYWORDS: antibody; cancer; f77; prostate
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1 posted on 12/28/2009 5:35:52 PM PST by LibWhacker
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To: neverdem

BTTT


2 posted on 12/28/2009 5:39:31 PM PST by Squantos (Be polite. Be professional. But have a plan to kill everyone you meet)
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To: LibWhacker

Wonderful news!

My FIL died of Prostate cancer in 2006, he lived with it for 7 years, moving from the prostate to the lungs, bone and finally brain. He is smiling right now.


3 posted on 12/28/2009 5:45:37 PM PST by Cathy
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To: Cathy
He is smiling right now.

I'm sure he is. Sorry for your loss. I really hate cancer. It's taken a number of people in my life, and always cruelly.

4 posted on 12/28/2009 5:49:42 PM PST by LibWhacker (America awake!)
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To: LibWhacker

Discover now because if they ram health care down our throats there will be less spent on research.


5 posted on 12/28/2009 5:51:39 PM PST by wiggen (Never in the history of our great country have the people had less representation than they do today)
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To: AdmSmith; Berosus; bigheadfred; Convert from ECUSA; dervish; Ernest_at_the_Beach; Fred Nerks; ...
US researchers have found an antibody that hunts down prostate cancer cells in mice and can destroy the killer disease even in an advanced stage
...the drawback is, you have to swallow a mouse...
6 posted on 12/28/2009 5:52:48 PM PST by SunkenCiv (My Sunday Feeling is that Nothing is easy. Goes for the rest of the week too.)
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To: LibWhacker

Someone please contact Imus and relay this information. I am sick and tired of hearing him spout about his prostate cancer woes.


7 posted on 12/28/2009 5:55:29 PM PST by nesnah
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To: LibWhacker

Anyone seriously think this will become a treatment?

I pray your right but people dying and spending years in treatment are all good things for Corporate America. Lots of profit in the suffering of others.

Have enough coin and you can jet off to Europe for an ‘experimental” cure like Magic..

I look for this treatment to be sidetracked soon..Maybe a good 10 years of testing and some fat checks will keep the creators quiet.

I pray I am wrong, Sadly suspect I am right.

W


8 posted on 12/28/2009 5:59:17 PM PST by WLR (Remember 911 Remember 91 Iran delinda est.)
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To: LibWhacker

Good news but not for a very good friend who died from prostate cancer on Dec. 19.

God willing, this will help others.


9 posted on 12/28/2009 6:02:55 PM PST by azishot (MERRY CHRISTMAS!!)
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To: Cathy

Rest in peace FIL.


10 posted on 12/28/2009 6:02:55 PM PST by cubreporter (.)
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To: LibWhacker

Yeah, but who gets prostrate cancer? Old guys. And they’re non-productive. So this research is a waste of “precious resources”. MengeleCare doesn’t exist to keep the non-productive alive. Sorry.


11 posted on 12/28/2009 6:31:03 PM PST by samtheman
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To: samtheman

hey pal, who you calling old? unless you arein 20 or30 ies, being 50 is not what I consider old. just went through last 19 months dealing with it.so give the name calling a rest.


12 posted on 12/28/2009 6:45:45 PM PST by Phinanceguy
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To: samtheman

No good sarcasm goes unpunished, you stinkin’ prostate basher.


13 posted on 12/28/2009 6:50:49 PM PST by Nervous Tick (Stop dissing drunken sailors! At least they spend their OWN money.)
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To: samtheman

I think you are being sarcastic. I got diagnosed and operated while 49.


14 posted on 12/28/2009 6:51:48 PM PST by Jay Thomas (A thankful prostate cancer survivor!!! Praise be to Jesus Christ!!!!!)
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To: LibWhacker

Sheesh, at this point aren’t mice nearing immortality?


15 posted on 12/28/2009 6:53:05 PM PST by Lancey Howard
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To: Lancey Howard

>> Sheesh, at this point aren’t mice nearing immortality?

ROFLMAO! Post of the day!


16 posted on 12/28/2009 6:54:41 PM PST by Nervous Tick (Stop dissing drunken sailors! At least they spend their OWN money.)
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To: Squantos

thanks, bfl


17 posted on 12/28/2009 7:02:06 PM PST by neverdem (Xin loi minh oi)
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To: LibWhacker; Squantos
Suppression of human prostate tumor growth by a unique prostate-specific monoclonal antibody F77 targeting a glycolipid marker
18 posted on 12/28/2009 9:39:50 PM PST by neverdem (Xin loi minh oi)
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To: LibWhacker

Monoclonal antibody drugs for cancer treatment: How they work

http://www.mayoclinic.com/health/monoclonal-antibody/CA00082


19 posted on 12/28/2009 11:16:16 PM PST by AdmSmith
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To: Jay Thomas; Nervous Tick; Phinanceguy
Yeah, but who gets prostrate cancer? Old guys. And they’re non-productive. So this research is a waste of “precious resources”. MengeleCare doesn’t exist to keep the non-productive alive. Sorry.
-- samtheman

hey pal, who you calling old? unless you arein 20 or30 ies, being 50 is not what I consider old. just went through last 19 months dealing with it.so give the name calling a rest.
-- Phinanceguy

I called it "MengeleCare" in my post, Phinanceguy. Do you really think, reading that, that I'm someone who believes that "old people" should be thrown under the bus? I'm mimicking the death panels and what we are ALL facing in the future from this monstrosity and the monsters who created it. And of course I don't think 50 is old or that only old people get prostate cancer. Again, I'm trying to mimic the bureaucratic thinking of the Death Panels.

Anyway, I hope you're doing well.

No good sarcasm goes unpunished, you stinkin’ prostate basher.
-- Nervous Tick

Thank you, Nervous Tick. I really didn't think I needed a sarcasm tag here. I thought that everyone, like you, would read my post for what it was: a put-down of MengeleCare, which is what I'm going to call this monstrosity from now on.

I think you are being sarcastic. I got diagnosed and operated while 49.
-- Jay Thomas

Yes, Jay Thomas, I was being sarcastic. I purposely left off the sarcasm tag because I was pretty sure I didn't need one.

I hope you're doing well.

20 posted on 12/29/2009 4:03:24 AM PST by samtheman
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