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Dr. Rodriguez discussed use of stem cells for treating SUI (Stress Urinary Incontinence). A stem cell is embryonic, adult, or engineered. Embryonic stem cells come from the blastocyst which is totipotent or pluripotent. These cells are immortal, identical clonal cells with long-term self renewal. Controversies include possible tumor formation, the difficulty maintaining cell cultures and ethical issues. Embryonic stem cells can differentiate into ectoderm, mesoderm and endoderm. Adult stem cells include hematopoetic stem cells, such as derived from bone marrow. This requires a bone marrow harvest, with low yield and difficulty to expand clones. A variety of other tissues have...

April 3, 2006 — The news is being hailed as a medical milestone: Several years after receiving new bladders engineered entirely in a laboratory, seven young patients are all still healthy. It marks the first long-term success of total-organ tissue regeneration, an area of medicine that until now was more the stuff of science fiction than clinical reality. Dr. Anthony Atala, the director of the Institute for Regenerative Medicine at Wake Forest University in North Carolina, reports in tomorrow's issue of the medical journal The Lancet on the success of the new procedure, which was performed on children born with...

In the first clinical study of its kind in North America, women with stress urinary incontinence (SUI) were treated using muscle-derived stem cell injections to strengthen deficient sphincter muscles responsible for the condition. Results of the study, led by researchers at the University of Pittsburgh School of Medicine and Sunnybrook Health Sciences Centre in Toronto, suggest that the approach is safe, improves patients' quality of life and may be an effective treatment for SUI. The findings will be presented at an experts' session at the annual meeting of the American Urological Association (AUA) in Atlanta, and will be published in...