Free Republic

Speech and guns: two of the most contentious issues in America today, with controversies fueled not only by personal passions and identity politics but by competing interpretations of the Constitution. Perhaps more than any other parts of the Constitution, the First and Second Amendments inspire religious-like fervor in many Americans, with accordingly irrational results. As legal texts go, neither of the two amendments is a model of clarity or precision. More important, both are deeply flawed in their respective conceptualizations of some of the most important rights of a democratic society: the freedom of expression and religion and the right...

Abstract A key driver in biopharmaceutical investment decisions is the probability of success of a drug development program. We estimate the probabilities of success (PoSs) of clinical trials for vaccines and other anti-infective therapeutics using 43,414 unique triplets of clinical trial, drug, and disease between January 1, 2000, and January 7, 2020, yielding 2,544 vaccine programs and 6,829 nonvaccine programs targeting infectious diseases. The overall estimated PoS for an industry-sponsored vaccine program is 39.6%, and 16.3% for an industry-sponsored anti-infective therapeutic....We plot the number of development programs known to start in each month from January 2000 through December 2019 in...

The probability of success (POS) of a clinical trial is critical for clinical researchers and biopharma investors to evaluate when making scientific and economic decisions. Prudent resource allocation relies on the accurate and timely assessment of risk. Without up-to-date estimates of the POS, however, investors may misjudge the risk and value of drug development, leading to lost opportunities for both investors and patients....The trials range from January 1, 2000, to October 31, 2015, the latter being the date that we received the data set... Of these, 34.7% (141,086) are industry sponsored and 65.3% (264,952) are non-industry sponsored. ...Table 1 contains...

QuestionShould I use you and me or you and I? Answer Whether to use I or me depends on whether the phrase is the subject of the sentence or the object of the sentence. I is a subject pronoun, and the subject is the person or thing doing the action as in "I went to the store." Me is an object pronoun, and the object is the person or thing the action happens to as in "Alex liked me." Use you and I when it is the subject of the sentence; use you and me when it is the object...

This is the port of Long Beach California. It is the second largest Port in North America, Ahead of the 3rd largest Port of New York, and Behind the largest Port which is the port of los angeles. Roughly 16 million Tons of Cargo pass through this port each year and makes its way to warehouses, factories, and homes, within the United States. This single port which is just 13 square kilometres, is responsible for well over $100 Billion dollars worth of trade and employs over 340 000 people in southern california. So, it is quite apparent that this port...

Want to command respect as if you were a badass Russian villain in a Hollywood film? Reckon you can do a better job than Harrison Ford’s questionable attempt at a Russian accent? Russia Beyond has you covered. A Russian accent is often imitated by English-speakers but rarely perfected. You’ll probably be familiar with the mean-sounding tone usually heard in Hollywood Russian accents, but do you know which sounds Russian speakers most commonly carry through to their spoken English? Follow these tricks, and you’ll be sounding like a native in no time! 1. Replace the 'i' with 'ee' There is no...

Japan began administering COVID-19 booster shots to health care workers nationwide on Wednesday (1 Dec) as the country braces for the potential impact of the omicron variant, a concerning new strain of the coronavirus that scientists worldwide are scrambling to research.Five doctors and 13 nurses at the state-run Tokyo Medical Center in Meguro Ward received their third jabs Wednesday morning. The hospital’s director, Kazuhiro Araki, who got the shot, said he feels relieved that the rollout began as scheduled.Medical personnel at Tokyo Medical University’s Hachioji Medical Center and some hospitals in Aichi and Saitama prefectures, among other facilities, also received...

Muslims by the millions are converting to Christianity. This has never happened before, and the astounding explanation given by many of the converts is that they are seeing dreams and visions of Jesus.

To the learned few words. Omicron, descrambled means 'moronic'. "Just saying..." mo·ron·ic (mə-rŏn′ĭk, mô-) adj. 1. Showing foolishness or stupidity. 2. Exhibiting mild intellectual disability. The term belongs to a classification system no longer in use and is now considered offensive. mo·ron′i·cal·ly adv. In oth

I've written about this several times, and here is another instance. The Guardian asks: "Is society coming apart?" Most of the article is throw away, but here we get something extremely important: According to the Reagan-Thatcher worldview, there is no such thing as society. There are only families, who look after one another, and individuals, who participate in markets. The idea that government is the solution to people’s problems rests on a mistaken belief in the existence of society.The amount of honesty in these few lines is rather quite remarkable. First off they are completely incorrect about the "Reagan-Thatcher worldview",...

Pharma-funded mainstream media has convinced millions of Americans that Dr. Anthony Fauci is a hero. He is anything but. As director of the National Institute of Allergy and Infectious Diseases (NIAID), Dr. Anthony Fauci dispenses $6.1 billion in annual taxpayer-provided funding for scientific research, allowing him to dictate the subject, content, and outcome of scientific health research across the globe. Fauci uses the financial clout at his disposal to wield extraordinary influence over hospitals, universities, journals, and thousands of influential doctors and scientists—whose careers and institutions he has the power to ruin, advance, or reward. During more than a year...

Catherine Austin Fitts brings together both an explanation of the pieces as they are fitting together and how to navigate the system. The collapse of the two party sytems and the over taking by those with a central banking background and the roll of taxation heading our way. Control Systems: *vaccine passport *CBDC (digital currency) *Universal Basic Income *and the development of the Smart Grid (think Branden's electrical grid in the infrastructure bill and his bbb bill) She discussed needing to pick a side. Slavery or Freedom. We are now at the fork in the road and it is time...

Tiger King star Carole Baskin’s former husband, who went missing in 1997 and was declared legally dead in 2002, is alive and well in Costa Rica.

Physicians Declaration II – Updated Global Covid Summit International Alliance of Physicians and Medical Scientists GlobalCovidSummit.org October 29, 2021 VIEW ORIGINAL DECLARATION WE, THE PHYSICIANS OF THE WORLD, united and loyal to the Hippocratic Oath, recognizing the imminent threat to humanity brought forth by current Covid-19 policies, are compelled to declare the following: WHEREAS, after 20 months of research, millions of patients treated, hundreds of clinical trials performed and scientific data shared, we have demonstrated and documented our success and understanding in combating COVID-19; WHEREAS, in considering the risks vs. benefits of major policy decisions, thousands of physicians and medical...

Looks like the science is in fact being settled. And the more the facts are learned the stronger the case is made against these experimental lab shots.

As a citizen historian, I find it both "funny" and annoying how skewed history is and how few treat leftist historians compared to their leftist journalist counterparts. Its a huge problem for us. Pimping a new book that he will hope you will buy, Andrew Roberts (the Book's author) writes this glowing piece for The Smithsonian about you know, George III, he wasn't all that bad of a guy! Hey I have an idea. Maybe we should've stayed under monarchism. That whole "liberty thing"? Perhaps that's overrated. Sarcasm aside, take a look at paragraph number 2: We can now see,...

The man who single handedly is holding journalism & journalists accountable and showing regular people how they're all inbred back scratchers.

As more and more Americans take a stand against Biden’s vaccine mandates, mounting evidence suggests the COVID injections could be even more dangerous than previously thought. One America’s Pearson Sharp has more.

Doctors tell One America News they are being threatened and silenced for raising questions about the effectiveness of coronavirus vaccines. One America’s Pearson Sharp sat down with Dr. Kirk Milhoan, a pediatric heart specialist, who explains the vaccine represents a greater danger to our children’s health than COVID itself.

Donald Trump heaped praise on Special Counsel John Durham on Monday, commending the prosecutor for the two indictments his years-long investigation into the 2016 Russia probe finally produced late this year and claiming it'll 'only get deeper' from here. The former president, 75, predicted that Durham's investigation, which he was first assigned to in April 2019, will show that 'it all leads back to the Democrats, Hillary [Clinton] and the dirty lawyers.' 'It really has come out,' Trump said to Fox after Durham produced his second of two indictments late last week. 'In all fairness, while it has taken a...