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Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases that commonly occur in middle-aged people. Both ALS and FTD arise from neuronal degeneration through mechanisms that remain unclear. Dr. Yun-Ru (Ruby) Chen's team recently discovered a new pathological mechanism for neuronal degeneration using synthetic peptides. They also discovered that a disaccharide can increase neuronal survival and reduce degeneration. The result provides therapeutic strategies for future treatment. ALS and FTD differ in clinical symptoms, but they share many pathological features and genetic variations. Clinical data shows that more than 90% of ALS and about 70% of FTD patients are...

A team of researchers has found that a metabolite produced by bacteria in the gut promotes neural cell death resulting in cognitive decline in mice. In their paper, the group describes their study of the metabolite isoamylamine (IAA) and its impact on cognitive decline. Prior research has suggested a strong link between gut bacteria and brain health. The researchers looked into the possible impact on the brain of just one metabolite produced by one family of bacteria in the gut, Ruminococcaceae. They found first that IAA becomes more prevalent in the gut as people age due to the presence of...

Physicists are building neural networks out of vibrations, voltages and lasers, arguing that the future of computing lies in exploiting the universe’s complex physical behaviors.Inside a soundproofed crate sits one of the world’s worst neural networks. After being presented with an image of the number 6, it pauses for a moment before identifying the digit: zero. Peter McMahon, the physicist-engineer at Cornell University who led the development of the network, defends it with a sheepish smile, pointing out that the handwritten number looks sloppy. Logan Wright, a postdoc visiting McMahon’s lab from NTT Research, assures me that the device...

Researchers at UC Santa Cruz have developed ultrasensitive nanoscale optical probes to monitor the bioelectric activity of neurons and other excitable cells. This novel readout technology could enable scientists to study how neural circuits function at an unprecedented scale by monitoring large numbers of individual neurons simultaneously. It could also lead to high-bandwidth brain-machine interfaces with dramatically enhanced precision and functionality. Monitoring the electrical activity of neurons is conventionally done using microelectrode arrays, but these are difficult to implement at a large scale and offer limited spatial resolution. In addition, the electronic wiring required for readout is a major limitation...

APPLE is reportedly working on a chip called the Apple Neural Engine, which would be dedicated to carrying out artificial intelligence (AI) processing on its iPhones. The addition of this type of capability would catalyse the use of AI on mobile devices. Although artificial intelligence is being used extensively already to power digital assistants like Siri and Google Assistant, these technologies rely on computer servers to process data sent to them rather than the processing happening on the mobile device itself. Augmented reality and digital assistants are not the only applications of AI that will become important on mobile devices....

Hawaii lawmakers are asking how much marijuana a driver can safely consume before getting behind the wheel of a car. It’s an issue they want to tackle now that Hawaii is setting up medical marijuana dispensaries. So Rep. Cindy Evans and 15 other lawmakers introduced a resolution asking the state Department of Health to study whether a person can safely drive while under the influence. Marijuana is the illicit drug most frequently found in the blood of drivers who have been involved in accidents, including fatal ones, but the role marijuana plays in those accidents is often unclear because it...

THE immune cells that attack the brains and nerves of people with multiple sclerosis could be turned into a weapon against the disease.This month sees the beginning of a trial of a personalised vaccine for MS, designed to rein in and destroy the renegade white blood cells that attack myelin cells lining the brain and nerves of patients.To make the vaccine, PharmaFrontiers of Woodlands, Texas, takes blood from an MS patient and extracts a sample of these renegade cells. The cells are then multiplied and weakened with radiation before being re-injected into the patient, whose immune system will then recognise...

<p>Technically, Stephen Thaler has written more music than any composer in the world. He also invented the Oral-B CrossAction toothbrush and devices that search the Internet for messages from terrorists. He has discovered substances harder than diamonds, coined 1.5 million new English words, and trained robotic cockroaches. Technically.</p>