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Keyword: mefenamic

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  • Pain medication finds new purpose fighting toxins from kidney disease

    02/05/2025 8:47:59 PM PST · by ConservativeMind · 5 replies
    Medical Xpress / University of Alberta / Expert Opinion on Drug Metabolism & Toxicology ^ | Jan. 28, 2025 | Adrianna MacPherson / Ala'a R. Al-Dajani et al
    Mefenamic acid, a common anti-inflammatory drug already approved for pain management, has been found to significantly reduce the formation of a toxic compound known as p-cresol sulfate in people with kidney disease with a minimal dose. "Right now, there's nothing drug-wise we can use to reduce this toxin quickly," says Tony Kiang. The body makes a compound called p-cresol when it breaks down proteins and amino acids. A healthy person's kidneys quickly get rid of the toxic sulfates. However, for the population with chronic kidney disease, they can accumulate to dangerous levels. "High levels of this toxin are correlated with...