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Keyword: mantlecelllymphoma

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  • Combined epigenetic and immunotherapy for blastic and classical mantle cell lymphoma (“Remarkably better” results)

    12/14/2022 3:43:54 PM PST · by ConservativeMind · 5 replies
    Medical Xpress / Impact Journals / Oncotarget ^ | Dec. 13, 2022 | Francis R. LeBlanc et al
    A new research paper titled "Combined epigenetic and immunotherapy for blastic and classical mantle cell lymphoma" has been published in Oncotarget. Classical MCL (cMCL) constitutes 6-8% of all B cell non-Hodgkins lymphoma (NHL). Despite recent advances, MCL is incurable except with allogeneic stem cell transplant. Blastic mantle cell lymphoma (bMCL) is a rarer subtype of cMCL associated with an aggressive clinical course and poor treatment response, frequent relapse and poor outcomes. In this new study, researchers treated 13 bMCL patients with combined epigenetic and immunotherapy treatment consisting of vorinostat, cladribine and rituximab (SCR). "We report an increased OS [overall survival]...