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Ibuprofen works wonders for your headaches, joint pain, muscle aches, and menstrual cramps, so it's probably no surprise that it's the second most common over-the-counter (OTC) drug behind paracetamol (Tylenol), according to a 2023 article https://pubmed.ncbi.nlm.nih.gov/36876700/ in the European Review for Medical and Pharmacological Sciences. You might get a prescription for ibuprofen if you have rheumatoid arthritis or osteoarthritis to reduce the pain and swelling from these conditions. Ibuprofen might also be used for psoriatic arthritis, arthritis of the spine, and gouty arthritis. Like other non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen works by blocking an enzyme that makes prostaglandins that cause...

Endocrine-disrupting chemicals, also known as EDCs, are natural or human-made substances that interfere with the healthy functioning of the body’s endocrine system. The endocrine system is made up of glands throughout the body, along with the hormones that these glands produce and receptors that respond to the hormones. Endocrine glands include the pituitary, thymus, pancreas and adrenals. Hormones act like messengers, traveling through the body to deliver instructions that control biological processes ranging from growth and development to sleep, digestion and childbirth. Humans have more than 50 hormones. These include estrogen and testosterone, which help to control sexual development, as...

Anyone who is taking a diuretic and a renin-angiotensin system (RSA) inhibitor for high blood pressure should be cautious about also taking ibuprofen, according to new research. Diuretics and RSA inhibitors are commonly prescribed together for people with hypertension and are available under various pharmaceutical brand names. Painkillers such as ibuprofen are available over-the-counter in most pharmacies and stores in popular brands. Researchers used computer-simulated drug trials to model the interactions of the three drugs and the impact on the kidney. They found that in people with certain medical profiles, the combination can cause acute kidney injury, which in some...

Will likely be facing vaccine mandate. Does anyone have thoughts on taking Ivermectin to offset side-affects of the vaccine?

World Health Organization recommends using paracetamol to treat coronavirus symptoms, instead of anti-inflammatories. Here's why. The World Health Organization has recommended that people suffering from the symptoms of the virus avoid taking ibuprofen drugs such as Advil. Instead, the organization suggests taking paracetamol, such as Acamol (Tylenol). They studied why the disease pathway in Italy is more serious, finding that most patients took ibuprofen at home. Researchers joined the virus and ibuprofen in the laboratory and came to the conclusion that administering ibuprofen accelerates multiplication of the virus and is related to a more serious course of the disease. They...

Scientists and senior doctors have backed claims by France’s health minister that people showing symptoms of covid-19 should use paracetamol (acetaminophen) rather than ibuprofen, a drug they said might exacerbate the condition. The minister, Oliver Veran, tweeted on Saturday 14 March that people with suspected covid-19 should avoid anti-inflammatory drugs. “Taking anti-inflammatory drugs (ibuprofen, cortisone . . .) could be an aggravating factor for the infection. If you have a fever, take paracetamol,” he said. His comments seem to have stemmed in part from remarks attributed to an infectious diseases doctor in south west France. She was reported to have...

CDC researchers found less addictive over-the-counter drugs, like Advil and Tylenol, are three times more effective than some of their opioid counterparts. No more opiates for chronic pain I guess.

Full Title: "Fresh blow for Mars missions as researchers find long-duration space travel causes crippling back pain that can last for up to four YEARS" The changes in muscle composition are still present up to four years after long-duration spaceflight, according to the new research by Katelyn Burkhart, MS, of Massachusetts Institute of Technology and colleagues. They write, 'Spaceflight-induced changes in paraspinal muscle morphology may contribute to back pain commonly reported in astronauts.' The researchers analyzed computed tomography (CT) scans of the lumbar (lower) spine in 17 astronauts and cosmonauts who flew missions on the International Space Station. Scans obtained...

TUCSON, AZ (Tucson News Now) - Tris Pharma, Inc. has voluntarily recalled three (3) lots of Infants' Ibuprofen Concentrated Oral Suspension, USP (NSAID) 50 mg per 1.25 mL, to the retail level. The recalled product has been found to potentially have higher concentrations of ibuprofen. The company is warning that there is a possibility that infants may be more vulnerable to permanent NSAID-associated kidney injury because they are more susceptible to a higher potency level of the drug. Side effects are nausea, vomiting, epigastric pain, or more rarely, diarrhea. Tinnitus, headache and gastrointestinal bleeding are also possible adverse effects. To...

A team of researchers from Denmark and France has found that taking regular doses of the pain reliever ibuprofen over a long period of time can lead to a disorder in men called compensated hypogonadism. In their paper published in Proceedings of the National Academy of Sciences, the group describes their study, which involved giving the drug to volunteers and monitoring their hormones and sperm production. To learn more about the possible impacts of the popular anti-inflammation drug Ibuprofen on male fertility when taken for long periods of time, the researchers asked 31 men between the ages of 18 and...

Ibuprofen and other painkillers may trigger a heart condition which affects almost a million Britons, a major study has shown. Patients who regularly take the pills are up to 20 per cent more likely to develop heart failure. Long-term use of the medication causes chemical reactions in the body which place extra strain on the heart, research suggests. This can lead to heart failure in patients who have a history of previous heart attacks or high blood pressure. An estimated 900,000 adults in Britain have heart failure which occurs when the muscle becomes too weak to pump blood around the...

Despite all the advances of modern medicine, the main drugs used to fight pain today are essentially the same as those used in ancient times. Hippocrates wrote about the pain-soothing effects of willow bark and leaves as early as 400 B.C. Opium was cultivated long before that. Aspirin and morphine, based on the active ingredients in these traditional remedies, were isolated in the 1800's and helped form the foundation of the modern pharmaceutical industry. But scientists are now trying to find new ways of fighting pain. The effort has been given new impetus by the recent withdrawal of Vioxx and...

Full Title: Could ibuprofen be an anti-aging medicine? Popular over-the counter drug extends lifespan in yeast, worms and flies Ibuprofen, a common over-the-counter drug used to relieve pain and fever, could hold the keys to a longer healthier life, according to a study by researchers at the Buck Institute for Research on Aging. Publishing in PLoS Genetics on December 18th, scientists showed that regular doses of ibuprofen extended the lifespan of yeast, worms and fruit flies. "There is a lot to be excited about," said Brian Kennedy, PhD, CEO of the Buck Institute, who said treatments, given at doses comparable...

Scientists in the UK have moved a step closer to understanding how ibuprofen could help treat cancer. The findings could lead to the drug being used as a preventative treatment for prostate cancer, in the future.Ibuprofen - a common painkiller - can help reduce the risk of prostate cancer, but the mechanism by which it inhibits tumour cells is still not fully understood. Now, Matthew Lloyd and his team from the University of Bath in the UK, in collaboration with Cancer Research UK, have uncovered a mechanism suggesting that the chiral inversion of ibuprofen inhibits the activity of the protein alpha-methylacyl-CoA...

Even short-term use of some painkillers could be dangerous for people who've had a heart attack, according to research published in Circulation: Journal of the American Heart Association. Researchers analyzed the duration of prescription non-steroidal anti-inflammatory drugs (NSAIDs) treatment and cardiovascular risk in a nationwide Danish cohort of patients with prior heart attack. They found the use of NSAIDs was associated with a 45 percent increased risk of death or recurrent heart attack within as little as one week of treatment, and a 55 percent increased risk if treatment extended to three months. The study was limited by its observational...

With flu vaccination season in full swing, research from the University of Rochester Medical Center cautions that use of many common pain killers – Advil, Tylenol, aspirin – at the time of injection may blunt the effect of the shot and have a negative effect on the immune system. Richard P. Phipps, Ph.D., professor of Environmental Medicine, Microbiology and Immunology, and of Pediatrics, has been studying this issue for years and recently presented his latest findings to an international conference on inflammatory diseases. (http://bioactivelipidsconf.wayne.edu/) “What we’ve been saying all along, and continue to stress, is that it’s probably not a...

Ibuprofen Destroys Aspirin's Positive Effect On Stroke Risk, Study Shows ScienceDaily (Mar. 17, 2008) — Stroke patients who use ibuprofen for arthritis pain or other conditions while taking aspirin to reduce the risk of a second stroke undermine aspirin's ability to act as an anti-platelet agent, researchers at the University at Buffalo have shown. In a cohort of patients seen by physicians at two offices of the Dent Neurologic Institute, 28 patients were identified as taking both aspirin and ibuprofen (a nonsteroidal anti-inflammatory drug, or NSAID) daily and all were found to have no anti-platelet effect from their daily aspirin....

High doses of ibuprofen raise heart attack risk By Celia Hall, Medical Editor Last Updated: 2:05am BST 05/04/2007 The common pain killer ibuprofen has been found to increase an existing risk of having a heart attack or a stroke in people who suffer from arthritis, research shows today. For some the risk was nine times higher. The findings bring more anxiety to the millions of arthritis sufferers in Britain as they follow a series of research studies that have shown increased risk of heart disease from the pain killers they take to ease the condition. The latest evidence comes from...

Ibuprofen can double risk of heart attack, says medical study By Celia Hall, Medical Editor (Filed: 02/06/2006) Common painkillers such as ibuprofen can double the risk of suffering a heart attack, a study has found. Research published in the British Medical Journal analysed results of 138 trials involving 140,000 patients over several years. It found that ibuprofen and diclofenac, two non-steroidal anti-inflammatory drugs (NSAIDs), could cause attacks when taken in high doses. Vioxx: Banned in 2004 The drugs have been previously noted for increasing heart attack risk but experts say that this is the biggest and most definitive study of...

Can a dietary supplement pick up the pieces? Glucosamine, often recommended for joint pain, is one of the most popular supplements on the market. And considering the health concerns recently associated with nonsteroidal anti-inflammatory medications, I thought it would be worth looking into whether glucosamine lives up to the hype.Background: Glucosamine and chondroitin are often combined together and used to treat osteoarthritis (OA), which occurs when the cartilage covering the end of the bone near the joint breaks down. OA affects the knees, backs, hips, hands and feet of more than 21 million people over age 45. And, according to...