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Scientists have discovered a new gene that makes mice happy, a finding that suggests another avenue of drugs for improving depression in humans. The research represents the first time that depression has been eliminated genetically in any organism, said Guy Debonnel, a psychiatrist and professor at McGill University. Debonnel and his colleagues achieved this effect by creating and breeding mice lacking a gene also found in humans that affects the transmission of the mood-modulating chemical serotinin. Mice without the gene, called TREK-1, acted as if they had been treated with anti-depressants for at least three weeks, he said. By removing...

07/26/04 -- Researchers have found a delivery method for gene therapy that reaches all the voluntary muscles of a mouse - including heart, diaphragm and limbs ? and reverses the process of muscle-wasting found in muscular dystrophy. "We have a clear 'proof of principle' that it is possible to deliver new genes body-wide to all the striated muscles of an adult animal. Finding a delivery method for the whole body has been a major obstacle limiting the development of gene therapy for the muscular dystrophies. Our new work identifies for the first time a method where a new dystrophin gene...

Its history is marred by failures, false hopes, and even death, but for a number of the most horrendous human diseases, gene therapy still holds the promise of a cure. Now, for the first time, there is reason to believe that it is actually working. Part I: By the late 1960s, molecular biologists had erected an overarching explanation of how genes work--their substance, their structure, their replication, their expression, their regulation or control. Or at least they had done so in outline, for prokaryotes, the simplest single-celled organisms (which include bacteria), and for the viruses, called bacteriophages, that prey upon...

A top American scientist dubbed "the father of gene therapy" is facing two decades in prison after been convicted of molesting a colleague's daughter. William French Anderson, known to many in the competitive world of genetic research as "French", entered the annals of medicine in 1990 when he led a team that successfully implanted missing genes into the blood of a 3-year-old girl, enabling her recovery from a rare, hereditary disease. But yesterday the 69-year-old was found guilty of four counts of abuse towards the 10-year-old daughter of a research scientist who worked in his laboratory at the University of...

LOS ANGELES A jury convicted world-renowned geneticist William French Anderson on Wednesday of molesting the daughter of a colleague. Anderson, 69, is widely credited as the "father of gene therapy," a promising but controversial experimental medical treatment that involves injecting healthy genes into sick patients. He was the first person to successfully treat a patient this way in 1990, launching the field. The white-haired Anderson sat stoically, staring straight ahead, his head held high. He showed no reaction as the verdicts were read. His wife, a renowned surgeon, sat in the front row of the spectator section behind him with...

Researchers at Rush University Medical Center, Chicago, and Ceregene Inc., San Diego, have successfully used gene therapy to preserve motor function and stop the anatomic, cellular changes that occur in the brains of mice with Huntington’s disease (HD). This is the first study to demonstrate that, using this delivery method, symptom onset might be prevented in HD mice with this treatment. Results of the study were published in the Proceedings of the National Academy of Sciencesof the United States, June 13, 2006. “This could be an important step toward a disease modifying therapy,” says co-author Jeffrey H. Kordower, Ph.D., director...

Is the cloning of human babies' tissue an insult to god? Posted at: 22:01 A proposal to create babies that are both cloned and genetically altered to prevent serious hereditary disease has been outlined by the leader of the team that created Dolly the sheep, re-igniting the debate on the moral implications of cloning human beings. Ever since news that Dolly had been cloned from an adult cell made headlines around the world, Prof Ian Wilmut has repeatedly said he is "implacably opposed" to cloning a human being. But in his forthcoming book After Dolly, serialised in The Daily Telegraph,...

China, with lower regulatory hurdles, is racing to a lead in gene therapy. Once a week, Hashmukh Patel, a 62-year-old retired semiconductor engineer from Silicon Valley, travels with his wife, Bena, from their Beijing hotel to Beijing-Haidian Hospital. They ride the crowded elevator to the ninth floor, enter a pleasant, sun-filled ward with private rooms, and Patel gets an injection that he hopes will save his life. Suffering from late-stage cancer of the esophagus, he has come to Beijing for a Chinese gene-therapy drug called Gendicine that's supposed to kill tumor cells. Patel tried just about everything before coming to...

In a study to be published in the January 2006 issue of Nature Biotechnology, researchers led by a team of scientists at Memorial Sloan-Kettering Cancer Center have devised a novel strategy that uses stem cell-based gene therapy and RNA interference to genetically reverse sickle cell disease (SCD) in human cells. This research is the first to demonstrate a way to genetically correct this debilitating blood disease using RNA interference technology. To prevent the production of the abnormal hemoglobin that causes sickle cell disease, a viral vector was introduced in cell cultures of patients who have the disease. The vector carried...

Genes help immunity disease boy Mustaf now attends nursery Gene therapy has been successfully used to treat a four-year-old boy with no immune system, a team of British scientists has revealed.The boy, named only as Mustaf, had the rare life-threatening immune disorder known as ada-SCID. Doctors at Great Ormond Street Hospital used a harmless virus to deliver stem cells containing a corrective gene. It is the first successful treatment of ada-SCID in the UK. Five children have been treated in Milan, Italy. Children with ada-SCID have no working immune system. They are susceptible to even the most minor infection....

LOS ANGELES (AP) - A renowned University of Southern California gene therapy scientist accused of molesting two children over the past 20 years posted bond and was released from jail, authorities said Monday. William French Anderson, 68, was released shortly after 5 a.m. on bond, according to the county Sheriff's Department Web site. No other information was immediately released. Anderson is accused of molesting a girl he instructed in martial arts between 1997 and 2001. He has pleaded not guilty to a count of continuous sexual abuse of a child under age 14 and five counts of committing a lewd...

Controversial theorist Aubrey de Grey insists that we are within reach of an engineered cure for aging. Are you prepared to live forever? On this glorious spring day in Cambridge, England, the heraldic flags are flying from the stone towers, and I feel like I could be in the 17th century—or, as I pop into the Eagle Pub to meet University of Cambridge longevity theorist Aubrey de Grey, the 1950s. It was in this pub, after all, that James Watson and Francis Crick met regularly for lunch while they were divining the structure of DNA and where, in February 1953,...

<p>Gene injections in rats can double muscle strength and speed, researchers have found, raising concerns that the virtually undetectable technology could be used illegally to build super athletes. A University of Pennsylvania researcher seeking ways to treat illness said that studies in rats show that muscle mass, strength and endurance can be increased by injections of a gene-manipulated virus that goes to muscle tissue and causes a rapid growth of cells.</p>

Parkinson's Gene Therapy Study Begins By MALCOLM RITTER AP Science Writer NEW YORK (AP) -- Researchers slipped billions of copies of a gene into the brain of a Parkinson's disease patient Monday, marking the first attempt to test gene therapy in a person with that disease. The patient, 55-year-old Nathan Klein of Port Washington, N.Y., said he was "feeling fine" in a telephone interview a few hours after the surgery. Klein said the disease gave him a tremor in his right arm, and made him shuffle and have to catch himself sometimes from falling. Medicines offer some relief, he said,...

Does human history have a future? In his latest work, Aliens in America, political philosopher Peter Augustine Lawler argues that the advent of the new biotechnology—cloning, gene therapy, Prozac, Ritalin, and the like—means that we must consider anew the possibility that Americans are lving near the end of history, a time when full equality will be achieved through the elimination of al that is distinctively human about us: the ability to passionately love and hate, to strive nobly for truth and wisdom, to search for God. For the elimination of human distinctiveness is now being systematically pursued through the biochemical...

NEW YORK - Scientists have successfully inserted a foreign gene into the DNA of mice that was later incorporated into growing hair shafts. "This will allow us to search for genes that will give a cosmetic benefit as well as potential therapeutic benefits when inserted into the hair follicle," said the study's lead author Dr. Robert M. Hoffman of AntiCancer Inc., a San Diego, California-based biotechnology company. While the green fluorescent protein (GFP) gene, which comes from jellyfish, has no medical significance, the main goal was to determine if the researchers could make transgenic mouse hair. The mouse genome did...

WASHINGTON (AP) _ A single injection of genetically modified stem cells is all it took to cure two children of a complex form of an inherited immune system disorder often referred to as the ``bubble boy disease,'' researchers report. An experimental technique that altered genes in bone marrow stem cells restored the immune systems of the children, researchers from Italy and Israel said in a study appearing in the journal Science. The children were born with what experts said was the most complex form of severe combined immunodeficiency disorder, or SCID. ``Both children have been cured but ... both will...