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This study is currently recruiting participants! First Received Date ICMJE January 19, 2015 Last Updated Date August 17, 2015 Start Date ICMJE January 2015 Estimated Primary Completion Date December 2015 (final data collection date for primary outcome measure) Current Primary Outcome Measures ICMJE (submitted: January 22, 2015) Change in hearing loss after 4 weeks of treatment [ Time Frame: 28 days ] [ Designated as safety issue: No ] To compare the change from baseline (Day 1 to Day 28) between AUT00063 and placebo, on a speech-in-noise deficit Original Primary Outcome Measures ICMJE Same as current Change History Complete list...

This study is ongoing, but not recruiting participants. Change in subjective Tinnitus after 4 weeks treatment [ Time Frame: 28 days ] [ Designated as safety issue: No ] To compare the change from baseline (D1 to D28) of the Tinnitus Functional Index overall score between AUT00063 (800 mg) and placebo. To further investigate the safety and tolerability profile of repeat administration of AUT00063 (assessing vital signs, physical examination, laboratory exams and ECG) [ Time Frame: 42 days ] [ Designated as safety issue: Yes ] To investigate the safety and tolerability of AUT00063 by assessing vital signs, physical examination,...

Ketamine, a drug that is used as an anesthetic, may be a way to safely treat pain, PTSD, depression, and ringing ears (tinnitus), a new study suggests. Since the drug is already approved by the Food and Drug Administration, it could potentially be available sooner and cost less. “It’s a lot more economical to repurpose drugs than to take a new drug and make it from scratch,” says David E. Potter, professor and chair of pharmaceutical sciences at Texas A&M University’s Rangel College of Pharmacy. “Not only in terms of dollars, but also in terms of time.” And because a...

A new study conducted by researchers from the Oregon Health & Science University and the Veterans Affairs Portland Medical Center suggests that a transcranial magnetic stimulation system typically used for depression treatment could also help alleviate the debilitating effects of a condition known as tinnitus. ===================================================================================================================== Tinnitus is a debilitating condition wherein an individual often hears a ringing or clicking sound even though there are no external sources of the sound present. It currently affects an estimated 45 million people, mostly veteran soldiers, living in the United States, according to the American Tinnitus Association (ATA), and a proven cure for...

FULL TITLE: Quiet that ringing in the brain: New drug promises relief from epilepsy and tinnitus with fewer side effects =================================================================================================== A new drug may treat epilepsy and prevent tinnitus by selectively affecting potassium channels in the brain, UConn neurophysiologist Anastasios Tzingounis and colleagues report in the 10 June Journal of Neuroscience. Epilepsy and tinnitus are both caused by overly excitable nerve cells. Healthy nerves have a built-in system that slams on the brakes when they get too excited. But in some people this braking system doesn't work, and the nerves run amok, signaling so much that the brain gets...

Robert Folmer of the Portland Veterans Affairs Medical Center gave people with chronic tinnitus transcranial magnetic stimulation as part of a study. Participants found their symptoms decreased by about a third. (Portland Veterans Affairs Medical Center ) ================================================================================================= Imagine dealing with stresses of every day, juggling the demands of family life and deadlines at work, with a constant ringing in your ears? That's just what millions of Americans who suffer from tinnitus face. Hope could be on the way. New research by the Portland Veterans Affairs Medical Center and Oregon Health & Science University found that a noninvasive technique involving...

Sensory hair cells in the cochlea of a Beethoven mouse treated with TMC2 gene therapy. In this confocal microscopy image, microvilli are shown in red and cell bodies in green. The human ear has about 16,000 sensory hair cells. Credit: Charles Askew :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: Using gene therapy, researchers at Boston Children's Hospital and Harvard Medical School have restored hearing in mice with a genetic form of deafness. Their work, published online July 8 by the journal Science Translational Medicine, could pave the way for gene therapy in people with hearing loss caused by genetic mutations. "Our gene therapy protocol is not...

An Irish start-up has created a completely new approach to the treatment of tinnitus, which uses technology Ross O’Neill of Neuromod Devices with a Mutebutton For some it’s a high-pitched drone, for others a whooshing, hissing or buzzing. The layman’s name for it is “ringing in your ears”. The medical term is tinnitus and it can completely disrupt people’s lives making it impossible for them to work, sleep, socialise or concentrate on simple tasks. There is no known cure. However, a new product from Irish technology start-up, Neuromod Devices, looks set to revolutionise its treatment. The product is called Mutebutton...

Dodgers prospect Alex Guerrero was the victim Tuesday of a Mike Tyson-like ear chomp by triple-A teammate Miguel Olivo, according to Guerrero’s agent, Scott Boras. Guerrero, a Cuban infielder who is in the first year of a four-year, $28-million contract, was scheduled to undergo plastic surgery to reattach the part of his ear that was bitten off by Olivo in a dugout altercation, Boras said.

Researchers at UNSW Australia have for the first time used electrical pulses delivered from a cochlear implant to deliver gene therapy, thereby successfully regrowing auditory nerves. The research also heralds a possible new way of treating a range of neurological disorders, including Parkinson's disease, and psychiatric conditions such as depression through this novel way of delivering gene therapy. The research is published today (Thursday 24 April) in the journal Science Translational Medicine. "People with cochlear implants do well with understanding speech, but their perception of pitch can be poor, so they often miss out on the joy of music," says...

Chronic tinnitus affects millions of Americans, and is the most widely reported disability among veterans. New research reveals the roots of the disease lie deep within the brain, and experimental therapies are providing hope for a cure. n Easter Sunday in 2008, the phantom noises in Robert De Mong’s head dropped in volume -- for about 15 minutes. For the first time in months, he experienced relief, enough at least to remember what silence was like. And then they returned, fierce as ever. It was six months earlier that the 66-year-old electrical engineer first awoke to a dissonant clamor in...

In 2008 NASA decided to send one of the heights of modern art — The Beatles' 1969 track "Across the Universe" — into the cosmos. And for 2013, one of the pillars of internet folk art is preparing for takeoff: An animated GIF is about to be sent into space for the first time ever. The message will be beamed over a giant radio dish in California tomorrow as part of the inaugural transmission of Lone Signal, a project that's hoping to communicate with extraterrestrials. The GIF will be sent toward Gliese 526, a potentially habitable solar system 17.6...

Pennsylvania scientists have discovered the cause of the chronic disorder known as tinnitus, and have also found a way to treat it. Their goal is a preventive strategy for individuals whose work situations could cause them to be exposed to very loud noise. University of Pittsburgh School of Medicine researchers found that an epilepsy drug known as retigabine prevents tinnitus in animal models, according to ScienceDaily. They published their findings in the Proceedings of the National Academy of Sciences. Strictly speaking, tinnitus isn't a condition, but a symptom of some type of disorder, like hearing loss related to age, a...

I didn't notice this before but if you zoom in on Obama's ear, it looks like it was edited. The ear hole is a funny shape and the color around it looks like it was retouched...

Reporting Derek Valcourt Filed under Health, Local, News, Seen On, Syndicated Local, Watch + Listen Related tags Ear, Hospital, Johns Hopkins, Johns Hopkins Ear, Johns Hopkins Hospital, Sherrie HWalters. Trending Popular Entertainment Photo Galleries Car Snapped: Celebrities Caught On The Go Celebrity Twins Notable Deaths Of 2012 All-Time Father-Son Celebrity Duos 25 Downs: NFL Injuries Over The Years » More Photo Galleries BALTIMORE (WJZ) — Johns Hopkins doctors are once again making history–this time by using a woman’s own tissue to build her a new ear. Derek Valcourt explains with doctors’ help, her own body has replaced what an aggressive...

UT Dallas researchers recently demonstrated how nerve stimulation paired with specific experiences, such as movements or sounds, can reorganize the brain. This technology could lead to new treatments for stroke, tinnitus, autism and other disorders. In a related paper, UT Dallas neuroscientists showed that they could alter the speed at which the brain works in laboratory animals by pairing stimulation of the vagus nerve with fast or slow sounds. A team led by Dr. Robert Rennaker and Dr. Michael Kilgard looked at whether repeatedly pairing vagus nerve stimulation with a specific movement would change neural activity within the laboratory rats'...

One should always understand that we are all different so that it is impossible to suggest a single form of treatment that will work in every case and for every person. However, there is a very simple technique that has often shown to be effective in many cases of tinnitus (ringing in the ears.) Any person who is afflicted by this very unpleasant condition would do well to at least give this simple technique a try. To perform this technique, put the palms of your hands over your ears. The fingers are on the back of the head. The middle...

It is estimated that only 20 percent of people who could benefit from hearing instruments seek help, many often waiting up to ten years from the time they could benefit from hearing amplification. Among those who try hearing instruments for the first time, acceptance can be slow and rejection rates high. Now, a new advanced technology hearing device from Oticon, Inc. shows the potential to deliver immediate benefits and motivate immediate acceptance by people new to hearing amplification. Results of a multi-center international study with first-time users conducted by researchers at Towson University in Baltimore, MD and Horzentrum in Oldenburg,...

University at Buffalo research showing that a new drug that eliminated tinnitus with a single dose in animal models is among the advances that will be presented at the Fifth Tinnitus Research Initiative Conference, "The Neuroscience of Tinnitus," sponsored by UB's Center for Hearing and Deafness Aug. 19-21 in Grand Island, N.Y. "The Neuroscience of Tinnitus" will explore new discoveries about the origins, diagnosis and treatment of tinnitus (the perception of sound without any acoustic stimulus), a disorder that affects 10-14 percent of Americans and is especially prevalent among Iraq and Afghanistan war veterans. While various therapies can help some...

A revolutionary biodegradable pellet which slowly releases antibiotics into the middle ear could transform the lives of thousands of children who suffer from glue ear. Scientists at The University of Nottingham have developed the tiny controlled-release antibiotic pellet which can be implanted in the middle ear during surgery to fit grommets, or small ventilation tubes. Over a period of three weeks it will release effective quantities of antibiotics to target any infection which can, in up to 20 per cent of cases, result in children having to return for a second and sometimes a third operation. The team has been...