Liver fibrosis is a major global health concern, developing as a result of chronic liver diseases (CLDs). Current treatment options are largely supportive, with no widely available therapies that directly target fibrosis. Research suggests that metabolic imbalances, particularly in glycolysis—the process by which cells generate energy—play a key role in disease progression. Identifying treatments that can disrupt these pathways may offer new therapeutic strategies. One emerging approach involves targeting liver sinusoidal endothelial cell (LSEC) glycolysis, which has been linked to inflammation and fibrosis. Quercetin, a naturally occurring flavonoid found in many fruits and vegetables, has attracted attention for its anti-inflammatory...