Quercetin: A natural solution with the potential to combat liver fibrosis

Medical Xpress / Association of Basic Medical Sciences of FBIH / Biomolecules and Biomedicine ^ | March 10, 2025 | Xiaoying Chen et al

[ConservativeMind]

Liver fibrosis is a major global health concern, developing as a result of chronic liver diseases (CLDs).

Current treatment options are largely supportive, with no widely available therapies that directly target fibrosis. Research suggests that metabolic imbalances, particularly in glycolysis—the process by which cells generate energy—play a key role in disease progression.

Identifying treatments that can disrupt these pathways may offer new therapeutic strategies. One emerging approach involves targeting liver sinusoidal endothelial cell (LSEC) glycolysis, which has been linked to inflammation and fibrosis.

Quercetin, a naturally occurring flavonoid found in many fruits and vegetables, has attracted attention for its anti-inflammatory and anti-fibrotic properties. Recent studies indicate that it may influence glycolysis, a metabolic process closely linked to liver fibrosis.

By reducing the activity of key glycolytic enzymes, quercetin lowers energy production in LSECs, potentially slowing fibrosis progression.

Additionally, it reduces the secretion of CXCL1, a chemokine associated with neutrophil infiltration and inflammation.

A study explored quercetin's effects using a mouse model of liver fibrosis.

Quercetin lowered levels of liver enzymes (ALT, AST) and total bile acid, markers of liver injury.

Mice treated with quercetin also showed decreased collagen deposition and lower levels of fibrosis markers, such as hyaluronic acid and procollagen type III.

In terms of metabolic regulation, quercetin inhibited glycolysis in LSECs, reducing lactate production, glucose consumption, and the expression of glycolytic enzymes. By suppressing CXCL1 secretion, quercetin decreased neutrophil infiltration, a key factor in liver fibrosis, thereby effecting inflammation control.

These findings highlight quercetin's potential as a therapeutic option for liver fibrosis by addressing both metabolic dysfunction and inflammation. By inhibiting LSEC glycolysis, it may disrupt key processes that drive fibrosis progression. Additionally, its ability to reduce inflammation could help mitigate liver damage and improve overall liver function.

[ConservativeMind]

You can get more quercetin from eating vegetables and fruits, and from supplements.

It may help with reducing liver fibrosis concerns.

[ConservativeMind]

The “Take Charge Of Your Health” Ping List
This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

[Williams]

Thank you as always.

[know.your.why]

I take this stuff daily.

[God luvs America]

So do i- I started taking it as part of kung flu prevention back in 2020 along with Vit D, zinc, niacin and artemesinin

[ConservativeMind]

We do, too, and it helps optimize collagen peptide use.

[CaptainPhilFan]

Good stuff! Another long time fan here. I take quercitan with bromelain. Bromelain is a liver healer by itself, builds collagen, other benefits.

Dx’d with NAFLD the same time my pituitary tumor was discovered, so I’ve been paying extra attention to that for a while. ;)

Milk thistle, dandelion, PQQ - a handful of other supplements that offer liver support and other benefits. My vitamin box is truly the most expensive item in my house.

SO FAR, thanks God, my blood tests always come back pretty ok. And that’s with a few nights a week after dinner cocktails.

Also, I keep a pretty clean kitchen, not too much processed food, most everything from scratch, no bad oils.

Oh, I can go face down in a bag of chips like nobody’s business, a pack of cookies are in mortal danger, and I raid the grandkid’s candy every visit.

It’s a balance, eh?

[TTFX]

The liver has the ability to store a lot of vitamin a and iron, but having excess is harmful.

[JZelle]

Thanks. Please add me to ping list.

[Albion Wilde]

Good post! Thanks!

[Faith65]

Thanks
BFL

[Pete from Shawnee Mission]

CM thanks for the post!

[peggybac]

I started taking Quercetin several years ago along with Vitamin C, Vitamin D3, and Zinc as a protocol to ward off Covid. Still take daily.

[Secret Agent Man]

That a lot of what I use as well

[Delta 21]

Me too.

[gleeaikin]

In fall of 2022 I had 3 loved ones with cancer whom I was trying to help. I saw one research study of 6 common cancers including liver and prostate, which were my concern. . Every cancer they studied had a severe lack of ZINC in their cancers. Their nearby normal tissues were usually well supplied with Zinc. One of the researches suggested they should try using an IONOPHORE with a name I did not recognized. Ionophores help Zinc get into virus infected cells to stop the virus. I have heard of about 5 ionophores. Quercetin and EGCG (from green tea) are 2 one can buy without a prescription. The Hydroxychloroquin/Zinc combo were mentioned by President Trump and Dr. Fauci in late March 2020 as a Covid treatment. By April, Zinc was no longer mentioned, and the media were saying HCQ was very dangerous, even though millions of people have been using it safely for malaria treatment for decades. Soon HCQ could only be bought with a doctor’s . Had Big Pharma told Fauci to shut zinc down because the combo was too successful?

At any rate I immediat4ely had my cancer sufferers start taking Quercetin and Zinc. I had also discovered that Astaxanthin makes cancer cells die younger and healthy cells live longer, so I added Astaxanthin. Mh brother soon reported his metastatic liver cancer had improved to the point doctors were suggesting surgery to remove some of the cancer tissues. He also proudly said he had taken his 4th Covid shot. My heart sank because I had just read a study showing that people taking multiple Covid shots had major (dangerous) changes in their IgG immune system. Two weeks later I called him and he was much worse and on a subsidized $20,000 last resort cancer medication, and also a much stronger (more misery producing) chemo. On the other hand, the person with prostate cancer, who also had six weeks of radiation treatment and anti-testosterone meds is completely well now. He also has worked hard to restrain his sweet tooth and taste for alcohol.

[CaptainPhilFan]

Thank you so much for that testimony.

It is wonderful to have the mind to research these things and not accept the status quo, and it’s more wonderful when someone will actually listen, and it’s a blessing when healing takes place.

I know I spend too many hours looking up various herbs and supplements and the types and bad ones and the good ones; and I listen to a few sources *I* deem trustworthy.

But, in the long run, I have no degree in this subject and I make no money from my efforts, and not many people listen to me, but a few have, and I don’t actually know if any of it does any good, but I feel better having the knowledge and the ability to offer something different for advice.

Astathanthin is a brand new one on this computer, I’ll have to look it up and add to the Library of Things Lisa Thinks Will Make You Get Better.

Nice to meet you :)

Thanks very much.