While manganese is an essential mineral involved in many bodily functions, both deficiency and excessive exposure can cause health issues. Chronic manganese exposure may result in a condition known as manganism, characterized by symptoms resembling Parkinson's disease, including tremors, muscle stiffness, and cognitive disturbances. New research employs model systems and human nerve cells to show the mechanisms by which manganese inflicts damage to the central nervous system. The study also suggests that the vitamin biotin may have a protective effect, potentially mitigating manganese-induced damage. "In this study, we applied untargeted metabolomics using high-resolution mass spectrometry and advanced cheminformatics computing in...