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Keyword: anticoagulants

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  • Common blood thinner may double as cancer therapy (Warfarin)

    08/07/2023 11:56:18 AM PDT · by ConservativeMind · 23 replies
    Warfarin, a widely used blood thinner, appears to have potent anti-cancer properties, according to a study. "Our findings suggest that warfarin, which is already approved by the FDA, could be repurposed to treat a variety of cancers, including pancreatic cancer," says Wei Gu, Ph.D. Cancer researchers are excited by the idea of harnessing ferroptosis—so-named because it requires iron to work—to kill cancer cells. Drugs that induce ferroptosis may be particularly useful for cancers that elude current treatments. Gu, Stockwell, and their colleagues performed genetic screens on human melanoma cells to identify genes that contribute to ferroptosis. As expected, the screens...
  • Anticoagulants do not reduce arterial thrombotic event risk in cancer

    07/09/2023 5:46:25 PM PDT · by ConservativeMind · 1 replies
    Medical Xpress / HealthDay / JACC: CardioOncology ^ | July 7, 2023 | Elana Gotkine / Yan Xu et al / Carmen Spaccarotella et al
    For ambulatory patients on systemic anticancer therapy, anticoagulants do not reduce the risk of arterial thrombotic events (ATEs) and are associated with increased bleeding risk, according to a review. Yan Xu, M.D. and colleagues examined the efficacy and safety of anticoagulants in ATE prevention among ambulatory cancer patients. The researchers performed a systematic review of studies comparing oral or parenteral anticoagulation with no anticoagulation among patients receiving systemic anticancer therapy with no other indication for anticoagulation. Data were included from 14 randomized trials involving low-molecular-weight heparins, direct oral anticoagulants, and warfarin. ATEs (myocardial infarction, ischemic stroke, intra-abdominal arterial embolism, or...
  • High-dose anticoagulation can reduce intubations and improve survival for hospitalized COVID-19 patients (25% - 30+% fewer intubations and death)

    03/08/2023 8:45:11 AM PST · by ConservativeMind · 8 replies
    High-dose anticoagulation can reduce deaths by 30 percent and intubations by 25 percent in hospitalized COVID-19 patients who are not critically ill when compared to the standard treatment, which is low-dose anticoagulation. These are the significant findings from the large-scale international "FREEDOM" trial, led by Valentin Fuster, MD, Ph.D. Patients were not in the ICU or intubated, and approximately half of them had signs of COVID-19 impacting their lungs with acute respiratory distress syndrome (ARDS). Patients were randomized to receive doses of three different types of anticoagulants within 24-48 hours of being admitted to the hospital and followed for 30...