Posted on 03/08/2023 8:45:11 AM PST by ConservativeMind
High-dose anticoagulation can reduce deaths by 30 percent and intubations by 25 percent in hospitalized COVID-19 patients who are not critically ill when compared to the standard treatment, which is low-dose anticoagulation. These are the significant findings from the large-scale international "FREEDOM" trial, led by Valentin Fuster, MD, Ph.D.
Patients were not in the ICU or intubated, and approximately half of them had signs of COVID-19 impacting their lungs with acute respiratory distress syndrome (ARDS). Patients were randomized to receive doses of three different types of anticoagulants within 24-48 hours of being admitted to the hospital and followed for 30 days.
Equal numbers of patients were treated with one of three different drug regimens: prophylactic subcutaneous enoxaparin, therapeutic subcutaneous enoxaparin, and therapeutic oral apixaban. They compared the combined therapeutic groups to the prophylactic group.
The primary endpoint was a combination of death, requirement for ICU care, systemic thromboembolism, or ischemic stroke at 30 days. This endpoint was not significantly reduced between the groups. However, 30-day mortality was lower for those treated with therapeutic anticoagulation (high dose) compared with those on the prophylactic regimen (low dose).
Seven percent of patients treated with the prophylactic anticoagulation died within 30 days compared with 4.9 percent of patients treated with therapeutic anticoagulation—an overall reduction of 30 percent. The need for intubations was also reduced in the therapeutic group: 6.4 percent of patients on the therapeutic regimen were intubated within 30 days compared with 8.4 percent in the prophylactic group—a 25 percent reduction.
The study showed therapeutic anticoagulation to be especially beneficial for patients with ARDS, a condition where COVID-19 damages the lungs. Among patients with ARDS at the time of hospital admission, 12.3 percent in the prophylactic anticoagulation group died within 30 days compared with 7.9 in the therapeutic anticoagulation group.
(Excerpt) Read more at medicalxpress.com ...
1) Prophylactic-dose enoxaparin (40 mg SC QD; 30 mg SC QD for creatinine clearance <30 mL/min);
2) Therapeutic dose enoxaparin (1 mg/kg SC Q12h; 1 mg/kg SC QD for creatinine clearance <30 mL/min);
3) Therapeutic-dose apixaban (5 mg PO BID; 2.5 mg Q12h for patients with at least two of three of age ≥80 years, weight ≤60 kg or serum creatinine ≥1.5 mg/dL)
Ivermectin works too!
HMMMMMMMMMMMM.....................
NEVER intubation! Literally it is a death warrant. Intubations are the worst thing for covid-19. Talk to any sane Dr. or nurse and they can quickly explain why intubation are one of the worst things you can do for this respiratory illness.
Hmmmmmm ..... is right.
NAC: Is this the one supplement everyone should be taking?
By Dr Frank Yap, M.D. - May 06, 2022
The nutritional supplement N-acetylcysteine is like the Swiss Army knife of supplements. It’s used to treat a wide range of health conditions, including allergies, Alzheimer disease, bipolar disorder, bronchitis, chronic kidney disease, cirrhosis, heart disease, hepatitis, infertility, schizophrenia, and upper respiratory infections......
https://covid19.onedaymd.com/2021/01/is-this-one-supplement-everyone-should.html
The effect of N-acetylcysteine on blood coagulation and platelet function in patients undergoing open repair of abdominal aortic aneurysm
https://pubmed.ncbi.nlm.nih.gov/16607076/
The effect of N-acetylcysteine on blood coagulation and platelet function in patients undergoing open repair of abdominal aortic aneurysm
https://hardball.parkoffletter.org/nac-dr-rober-sehault/
NAC: Is this the one supplement everyone should be taking?
By Dr Frank Yap, M.D. - May 06, 2022
The nutritional supplement N-acetylcysteine is like the Swiss Army knife of supplements. It’s used to treat a wide range of health conditions, including allergies, Alzheimer disease, bipolar disorder, bronchitis, chronic kidney disease, cirrhosis, heart disease, hepatitis, infertility, schizophrenia, and upper respiratory infections......
https://covid19.onedaymd.com/2021/01/is-this-one-supplement-everyone-should.html
The effect of N-acetylcysteine on blood coagulation and platelet function in patients undergoing open repair of abdominal aortic aneurysm
https://pubmed.ncbi.nlm.nih.gov/16607076/
The effect of N-acetylcysteine on blood coagulation and platelet function in patients undergoing open repair of abdominal aortic aneurysm
https://hardball.parkoffletter.org/nac-dr-rober-sehault/
Is not the gov’t trying to make NAC a prescription drug rather than OTC supplement??
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