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In 2016, Spinraza became a game-changer for spinal muscular atrophy (SMA) patients. It was the first FDA-approved treatment for the neurodegenerative disease, which is the leading genetic cause of infant death. The drug was conceived and developed by Professor Adrian Krainer. His lab has been investigating whether Spinraza could be improved. They discovered pairing Spinraza with a second FDA-approved drug called valproic acid (VPA) could be a new way to boost its therapeutic effects. One way to improve the effect of a drug is by increasing its dosage. But as with any drug, increasing the amount of Spinraza also increases...

The company which is Apple’s most important chip supplier, said it expects revenue to be between $19.8 billion and $20.6 billion in the third quarter, surging from $14.8 billion in the same period last year. However, TSMC CEO CC Wei said that some of the company’s capital expenditure would be “pushed out into 2023.” He cited “greater challenges in the supply chains” which is extending delivery times for some chipmaking equipment. The strong results and outlook but caution on spending highlights the careful path chipmakers are walking at a time of concern about rising prices and the impact on consumer...

A greater percentage of Americans believe former President Donald Trump should run again in 2024 than say the same of President Joe Biden, a Politico/Morning Consult survey released this week found.The survey asked respondents if they believe Trump should run for president in 2024. Thirty-five percent, overall, said he either “definitely” or “probably” should, while 61 percent said he either “definitely” or “probably” should not. However, the survey asked respondents the same of Biden and found that even fewer believe he should run for reelection in 2024.According to the survey, 28 percent believe Biden should either “definitely” or “probably” run...

US President Joe Biden held bilateral talks on Thursday (July 14) with Israeli officials.

Patients with multiple sclerosis (MS) treated with the drug rituximab had a significantly lower risk of relapse compared with MS patients receiving standard treatment. Rituximab is not approved as an MS drug, but has proven to be effective in smaller studies and is therefore largely prescribed "off label." The Phase 3 trial is a study involving patients who were newly diagnosed with the most common form of MS, relapsing-remitting MS. Patients were randomly given either rituximab (Mabthera) or standard dimethyl fumarate (Tecfidera) treatment. During the 24-month follow-up, the occurrence of relapses, i.e., a temporary deterioration of the disease state, was...

Joe Biden and Prime Minister Yair Lapid expressed a public disagreement over the best way to tackle the threat, with Lapid telling the American leader that “words will not stop them, Mr. President,” and urging him to “put a credible military threat on the table.” Biden said, “I continue to believe that diplomacy is the best way.” Minutes before, the two leaders signed a joint strategic declaration, in which the US vowed to use “all elements in its national power” to prevent Iran from obtaining nuclear weapons. “The United States stresses that integral to this pledge is the commitment never...

“So, we’re proposing an exception that would allow Russia to export as long as the price doesn’t exceed a to-be-determined level. Otherwise, Russia faces a situation where it will be completely cut off from those critical services, and that’s likely to shut-in a substantial amount of Russian oil,” the official warned. She said the mechanism should be viewed as “mitigating the impact that the insurance and financial services ban would otherwise have.” “It will give Russia a way to continue exporting oil at a price I expect would be quite profitable for them relative to shutting it in,”

Indiana Attorney General Todd Rokita, a Republican, said this week that his office will investigate the doctor who provided an abortion to a 10-year-old rape victim from Ohio. In an interview with Fox News’ Jesse Watters this week, Rokita said his office will investigate Dr. Caitlin Bernard, an OB/GYN in Indianapolis who told the Indy Star in a story published on July 1 that she provided care to a 10-year-old patient who was six weeks and three days pregnant. Bernard was connected to the patient after receiving a call from a child abuse doctor in Ohio. Allegedly, Ohio’s pro-life laws...

Indiana Attorney General Todd Rokita, a Republican, said this week that his office will investigate the doctor who provided an abortion to a 10-year-old rape victim from Ohio. In an interview with Fox News’ Jesse Watters this week, Rokita said his office will investigate Dr. Caitlin Bernard, an OB/GYN in Indianapolis who told the Indy Star in a story published on July 1 that she provided care to a 10-year-old patient who was six weeks and three days pregnant. Bernard was connected to the patient after receiving a call from a child abuse doctor in Ohio. Allegedly, Ohio’s pro-life laws...

Things have not been the same since June 2021 for 53-year-old Douglas Howey from Colorado. Around a year after he received the second dose of the Moderna COVID-19 vaccine, the 6 foot 4 and a half inch paraplegic man who once weighed 262 pounds lost over 100 pounds after the sudden onset of amyotrophic lateral sclerosis (ALS), an incurable and fatal disease that gradually kills a person’s motor neurons. Douglas Howey before and after amyotrophic lateral sclerosis, Douglas has lost more than 100 pounds between the two photos (Courtesy of Linda Howey/The Epoch Times) ================================================================== Though he never told his...

The project, based on the Clintons' The Book Of Gutsy Women, follows the mother-daughter duo as they interview their "personal heroes" Finally, something to watch with your neo-liberal mom and republican grandma besides The View! Chelsea and Hillary Clinton have a new docuseries at Apple TV+, Gutsy, based on their acclaimed book The Book Of Gutsy Women. The series appears to somewhat take on the format of Jada Pinkett Smith and Willow Smith’s Facebook Live series Red Table Talk, wherein the Smiths invite on different guests to discuss hot-button emotional issues. Gutsy will follow the Clintons on a “thought-provoking” journey...

After receiving the Presidential Medal of Honor, Joe Biden turned around and shook hands with a ghost. President Isaac Herzog assisted feeble Joe and helped him walk over to a chair

Congresswoman Alexandria Ocasio-Cortez says she still feels unsafe in the Capitol because there's been no explanation as to why Capitol police opened the doors for rioters on January 6, 2021.

A District Court judge in Ohio granted a temporary injunction Thursday on the Air Force's COVID-19 vaccine mandate for all of the branch's members requesting a religious exemption. U.S. District Court Judge Matthew McFarland, of the Southern District of Ohio, granted the 14-day injunction in the case of Doster v. Kendall, giving the government seven days to respond and explain "why this Court should not grant a class-wide preliminary injunction," according to the court order. The injunction applies to the entire Air Force and Space Force, including the Air Force Reserve, which submitted a Religious Accommodation Request. No punishment, discipline,...

A tangled, string-like object sits on the sandy brown Martian ground with a rock nearby. This tangled mess of something is likely debris left over from Perseverance's arrival on Mars. NASA/JPL-Caltech I just checked, and there are no Italian restaurants on Mars. So there goes one explanation for an odd object photographed by NASA's Perseverance rover on Tuesday. It isn't spaghetti. Nor is it a sea creature or a hair ball. It looks like a tangle of string or shredded material that's clinging together. Mars landscape with the Perseverance rover's robotic arm inspects a flat rock near the center. A...

Poland has accused Belarus of ‘barbarism’ after a Polish WWII memorial was ‘razed to the ground’. The memorial in the western village of Mikuliszki contains the remains of the wartime headquarters of a Polish Home Army unit whose members died in combat in the area in 1944. Belarusian website glosznadniemna.pl ran several pictures of the location, showing only bare earth where the headquarters and crosses commemorating the fallen soldiers had stood. The Home Army (AK) was the main resistance movement in Poland during World War Two. Posting on social media, MP Robert Tyszkiewicz, Chairman of the Committee for Liaison with...

Rep. Alexandria Ocasio-Cortez (D-NY) tore into U.S. Capitol Police for failing to forestall the Jan. 6 Capitol riot, alleging some officers were sympathetic to the event. Ocasio-Cortez stressed that authorities never "got to the bottom" of whether officers aided and were "opening the doors" to rioters who stormed the Capitol while warning fellow lawmakers, "We're not safe" at the Capitol. "There were actual officers working with this, and we never got to the bottom of that, and we never got any answers about that," Ocasio-Cortez said Wednesday. "I have no idea what happened to the people on the inside, who...

There has been a lot of talk for the past year and a half about who the Republican Party should nominate for 2024: Donald Trump or Ron DeSantis. I explain in this video why Donald Trump is still the guy for 2024.

Rep. Alexandria Ocasio-Cortez (D-NY) said she was on the verge of hitting a man who called her his "favorite big booty Latina” outside the Capitol on Wednesday. The harasser, right-wing provocateur Alex Stein, recorded himself as he catcalled the congresswoman and posted the video on his Twitter account. Ocasio-Cortez later shared Stein's video, calling it a "deeply disgusting incident." "I was actually walking over to deck him because if no one will protect us then I’ll do it myself but I needed to catch a vote more than a case today," Ocasio-Cortez tweeted after the incident. "It’s just a bummer...

Yesterday was an educational day. Josh Hawley took on a looney from Berkeley- but aren't they all? I've seen lots of claims of how Khiara Bridges "pwned" Hawley but saner and more mature minds saw it differently. During a hearing on the impact of the Supreme Court decision to overturn Roe Hawley and Bridges, a law professor from Berkeley, got into an animated discussion which made clear how far from reality the left has gotten. Hawley asked some simple questions of a highly insecure person and was insulted repeatedly. 'You've used a phrase I want to make sure I understand...