Posted on 03/27/2005 8:43:26 PM PST by NormsRevenge
WASHINGTON (Reuters) - A new chemical compound, part-cat and part-human, may provide an end to misery-making cat allergies, U.S. researchers reported on Sunday.
And they said their approach in creating the compound may work against more dangerous allergies, such as deadly peanut allergies.
The compound, tested in mice bred to be allergic to cats, virtually shut down the histamine reaction that causes the uncomfortable symptoms of cat allergies such as runny eyes, sneezing and itching, Dr. Andrew Saxon of the University of California Los Angeles School of Medicine and colleagues reported.
Writing in the April issue of Nature Medicine, they said their compound also worked in human cells grown in lab dishes.
"This novel approach to treating cat allergies is encouraging news for millions of cat-allergic Americans. Moreover, these results provide proof-of-concept for using this approach to develop therapies to prevent deadly food allergy reactions as well," said Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases (news - web sites), which paid for the study.
Allergies are caused when the immune system mistakenly reacts to allergens -- pieces of protein found in food, on animals or produced by plants. One response is the production of histamine, which brings on allergy symptoms such as sneezing, wheezing, itching, watery eyes and sometimes asthma.
The compound stops this process. It uses pieces of an allergy-provoking protein found in cat saliva or dander called Fel d1, tied to a piece of human antibody called IgG Fcg1. The UCLA team named it GFD, or gamma Feline domesticus.
The cat allergen part attaches to antibodies on the surface of the immune system cells that produce histamine, while the human bit stops the cell from getting started.
"We measured more than 90 percent less histamine in the (human cell) cultures with GFD," Saxon said. "Those results suggested that GFD successfully prevented the immune cells from reacting to cat allergen. The next step was to test GFD in mice that we had made allergic to the allergenic protein found in cat saliva and dander."
The researchers tested GFD in two types of allergic mice, and it blocked the immune over-response in both.
The approach could be used to protect people from a wide array of allergies, the researchers said.
"A new chemical compound, part-cat and part-human..."
Paging Dr Moreau...
Any compounds to prevent cats?
Cat ping.
I didn't know you had to breed them for that.
We are talking about food allergies, right?
I hate cats too.
OK, now they need to work out a fix for dogs and im swell... Im alergic to cats, dogs and any other rodent with fur.
Now THAT would be some valid research.
In the meantime, we could get kitty birth control put in all cat food. :)
I wish they would go straight to the other possible uses. I have already decided I am not getting anymore cats.
Alternatively, we could send them all to Florida.
That should keep "Judge" Greer busy!
I get asthma and hives. So naturally my husband lets our cat in the house. I adopted the cat from one neighbor who passed away to control the rats coming from another neighbors yard.
I hate Meeses to Pieces...
Actually, I read about a study about why people who either don't like, or are alergic to cats, seem to attract them... (this is series, not a joke...)
For a lot of people who are either alergic to cats, or simply don't care for them, that they become "cat magnets" when visiting the homes of friends who own cats.
Researchers have found that these people tend to avert their eyes when they see a cat, and the cat fixes on them as a "subordinate" in the group. It then comes over to "mark you" with its scent glands, on the face or base of the tail.
For those who don't want a cat to come over, be sure to meet its gaze, and in effect, stare it down, letting it know that you're superior. Then the cat will tend to keep its distance.
Mark
Thank'ee.
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Kitty Ping List alert!
[Freepmail me to get on or off the Kitty Ping List.]
No, thanks. I'm allergic to liberals and I don't want to get better.
I've found that 22 works real well.
That technique works well on women too.
That technique works well on women too.
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