Posted on 10/20/2025 9:05:02 PM PDT by ConservativeMind
A new study shows that the widely used antidepressant fluoxetine does more than boost serotonin levels: it changes how brain cells manage their energy and rebuild their connections, potentially helping the brain "loosen up" and adapt during depression treatment.
Using cell type–specific transcriptome profiling, researchers found that after two weeks of treatment, a special class of brain cells, called parvalbumin interneurons, which help keep brain activity balanced, became less rigid in the prefrontal cortex. Their mitochondria showed reduced expression of genes linked to energy production, while genes related to plasticity were upregulated.
At the same time, the protective perineuronal nets that normally restrict plasticity weakened. Together, these changes may allow the brain to enter a more plastic, or adaptable, state, though the causal links between them remain to be clarified.
This is important, since depression is linked to overly rigid brain circuits that resist change, and by softening these circuits and altering how their mitochondria function, fluoxetine may create a window of plasticity or flexibility in the brain. The findings also suggest new biological markers, such as mitochondrial changes or weakened perineuronal nets, that could one day guide or improve treatment.
"The findings point to a new understanding of how antidepressants may help people recover: not only by lifting mood, but by giving the brain room to rewire its circuits by altering its energy systems," says Juzoh Umemori.
Fluoxetine is widely sold under the brand name Prozac, but is internationally available under many different brand names.
(Excerpt) Read more at medicalxpress.com ...
This seems to point to needing just a short time with the drug, if also working toward life changes.
Loser pills.
I’ve been tried on several antidepressants over the years. None of them did me any good at all, so I’m not on any. Just recently, I watched an old Derek Prince video on YouTube, on deliverance, and following his instructions, was delivered from depression. I had been depressed all my life, since I was a little child. It’s wonderful to be free from it at last!
kinda need energy to induce the plasticity the comes from repetitive movement
Most prescriptions are. Depression in the vast majority of people is a self induced inability to deal with life.
Will it help my gold swing?
Bkmk
Super Fantastic Elastic Plastic, guaranteed to stretch you mind!...................
Truth
Loser perspective.
Rigid thinking.
Prozac is for losers like you.
. . . unwrapping the individual's indoctrinated inhibitions needed for a moral benevolent society. Beware!
Figuratively speaking, the history of mass shootings is contiguous with that of the beginning and upsweep of psychoactive "magic bullet" drugs, particularly the antidepressants like tricyclic or SSRIs, of which Prozac is an outstanding example. Te time of the antitubercular derivatives was coincident with the Texas Tower shootings in the 1950s.
A history of Prozac can be read here: "The Story of Prozac: A Landmark Drug in Psychiatry"(click here). This narrative includes the statement "The search for a drug specifically targeting depression began with the work of the pioneering psychopharmacologist Nathan S. Kline in the 1950s" (underline added).
It was at the time of the experimental trials of fluoxetine (Prozac) in the 1960s that a wholly unexpected event happened with an otherwise very talented youth undergoing suicidal thoughts, erupted in Olean, New York with Anthony Barbaro(click here) during the Christmastime closure (1074) of his high school, anothe of the early mass shootings that turned out to be the hint of a long wave of more to come.
What I've remarked in the years studying the social effects of these psychoactive drugs is that often a freeing of the libido, with an effect of breaking the bonds of inhibitions acquired from the culture and its training of the interpersonal peace-keeping behaviors, has loosed Satan's demons into a previously moral society.
So beware of the anecdotal interpretation that this article might confer to the reader, that one outcome of the use of fluoxetinr-like drugs might be a good thing without a minatory shadow looming over it.
I feel that the massive ingestion of these inhibition-loosing drugs, worse than the similar consequences of ethanol toxin, have turned the whole world of wrong-thinkink killers on the society who for its sins need a Savior.
There are other, better ways of retraining the brain than drugs with NASTY side effects.
I think gambling rewires the brain too, but don’t try it. 😂🤣🤪
It does, and that’s good advice.
Fortunately that is something I have never been tempted with.
We had far too little when I was growing up to throw my money away on long shots. I worked to hard for it and am very suspicious of people who want me to donate to their cause or try to guilt trip me into giving money to the *homeless*.
AMEN!!
Ain’t GOD wonderful!!!
Probably not, but it could help your silver slide.
Me too.
I know the math, and it ain't in my favor.
Zero sum games at least are balanced, but whenever the house takes a cut, EVERYONE (the aggregate) loses!
The 'sports betting' commercials gall me! They somehow convince folks that they can predict the future, and then can make money from that 'prediction'!
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