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Anti-obesity medications can normalize testosterone levels in men
Medical Xpress / The Endocrine Society / ENDO 2025, the Endocrine Society's annual meeting ^ | July 14, 2025 | Shellsea Portillo Canales, M.D. et al

Posted on 07/23/2025 8:57:12 PM PDT by ConservativeMind

Anti-obesity medications can significantly raise testosterone levels and improve health outcomes for men with obesity or type 2 diabetes, according to a new study.

Testosterone not only plays a critical role in the body when it comes to male sexual functioning, but it can also have an impact on an individual's bone mass, fat distribution, muscle mass, strength and red blood cell production. Increases in body weight and prevalence of type 2 diabetes are often associated with lowered testosterone levels, resulting in fatigue, decreased libido and quality of life.

"While it is well known that weight loss from lifestyle changes or bariatric surgery increases testosterone levels, the impact that anti-obesity medications may also have on these levels has not been widely studied," said Shellsea Portillo Canales, M.D. "Our study is among the first to provide compelling evidence that low testosterone can be reversed with the use of commonly prescribed anti-obesity medications."

To test this hypothesis, researchers analyzed the electronic health records of 110 adult men with obesity or type 2 diabetes being treated with the weight-loss medications semaglutide, dulaglutide or tirzepatide and who were not on testosterone or hormonal therapy. Participants' total and free testosterone levels were measured before and during treatment over the course of 18 months.

Along with 10% weight loss, the proportion of men with normal levels of both total and free testosterone rose from 53% to 77%. These findings indicate that anti-obesity medications can also have a positive effect on the reproductive health of men with obesity or type 2 diabetes.

"Results from this study show that there is a direct correlation between the use of anti-obesity medications and testosterone levels," said Portillo Canales. "Doctors and their patients can now consider this class of medications for the treatment of men's reproductive health."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: men; testosterone

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Free testosterone rebounds for 77% of men who lost 10% of their weight.
1 posted on 07/23/2025 8:57:12 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

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2 posted on 07/23/2025 8:57:43 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind
Free testosterone rebounds for 77% of men who lost 10% of their weight.

I suppose I could have a limb amputated. I just need to calculate which one, an arm or a leg.

3 posted on 07/23/2025 8:59:46 PM PDT by BipolarBob (I live by trial and error. Mostly error.)
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To: BipolarBob
I suppose I could have a limb amputated. I just need to calculate which one, an arm or a leg.

Adam only had to give up a rib and he scored big time. Well...at least for a while.
4 posted on 07/23/2025 9:03:16 PM PDT by know.your.why
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To: know.your.why

Thats actually a punch line from a pretty good chauvinist joke. God tells Adam that hes has come up with the answer for his loneliness and its so amazing that its beyond anything he could possibly imagine. “But its going to cost you an arm and a leg” God says. “An arm and a leg???” Adam shoots back. “Thats pretty steep! What can I get for...say...a rib?” And the rest is history.


5 posted on 07/23/2025 9:08:15 PM PDT by know.your.why
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To: ConservativeMind

I’ll take anything if it will just help get rid of some this excess testosterone.


6 posted on 07/23/2025 9:08:21 PM PDT by ansel12 ((NATO warrior under Reagan, and RA under Nixon, bemoaning the pro-Russians from Vietnam to Ukraine.))
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To: know.your.why

That’s why God made dogs, to make up for women.


7 posted on 07/23/2025 9:09:10 PM PDT by ansel12 ((NATO warrior under Reagan, and RA under Nixon, bemoaning the pro-Russians from Vietnam to Ukraine.))
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To: ConservativeMind

Not anything new. Fat acts like female hormones on guys, similar to estrogen.


8 posted on 07/23/2025 9:18:26 PM PDT by Secret Agent Man (Gone Galt; not averse to Going Bronson.)
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To: ConservativeMind

Just love how big pharma comes up with these enticements for their products...anything to do with growing bald men’s hair back or their sexual ability grabs their attention....


9 posted on 07/23/2025 9:29:07 PM PDT by cherry
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To: ConservativeMind

“Free testosterone rebounds for 77% of men who lost 10% of their weight.”

- - - - - - - -

10% of what? water, fat, muscle mass?

Quantify the numbers. Also, if a body reduces its overall weight by 10% - of course the amount of testosterone will go up as a percentage of the body weight.

There are, am given to understand, three ways to measure testosterone - free, bound, blood (appx)

Many ways to massage these numbers. Would check the Life Extension Foundation for more information, as they researched this years ago, not using drugs.

www.lef.org

Who paid for this study - let us see who benefits.


10 posted on 07/23/2025 10:07:44 PM PDT by Norski
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To: know.your.why

God made man and rested. God made woman and no one has rested since.


11 posted on 07/23/2025 11:13:16 PM PDT by Right Brother (I don't really care Margaret.)
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To: Right Brother

God made women because sheep can’t cook.


12 posted on 07/24/2025 1:47:47 AM PDT by BerryDingle (I know how to deal with communists, I still wear their scars on my back from Hollywood-Ronald Reagan)
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To: ConservativeMind

Bkmk


13 posted on 07/24/2025 6:00:07 AM PDT by sauropod (Make sure Satan has to climb over a lot of Scripture to get to you. John MacArthur Ne supra crepidam)
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To: ConservativeMind
I lost 28 lb. in 57 days taking Mounjaro.

I've noticed no change in testosterone or need to test blood testosterone levels, inasmuch as I have always felt its propulsion.

14 posted on 07/24/2025 6:04:44 AM PDT by Savage Beast (Unchecked mass insanity of woke will be more devastating than all the wars and plagues of the past.)
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To: know.your.why

I read that joke to my wife—and braced for the frying pan—but to my relief she laughed out loud. You never know.


15 posted on 07/24/2025 6:18:20 AM PDT by Savage Beast (Unchecked mass insanity of woke will be more devastating than all the wars and plagues of the past.)
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To: ansel12

Gee I dunno...I never could get used to doing it with dogs.


16 posted on 07/24/2025 6:21:37 AM PDT by Savage Beast (Unchecked mass insanity of woke will be more devastating than all the wars and plagues of the past.)
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To: Savage Beast

At least we got loyalty and devotion.


17 posted on 07/24/2025 6:25:35 AM PDT by ansel12 ((NATO warrior under Reagan, and RA under Nixon, bemoaning the pro-Russians from Vietnam to Ukraine.))
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