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High phosphate diet impacts nervous system, induces hypertension
Medical Xpress / UT Southwestern Medical Center / Circulation ^ | June 30, 2025 | Han-Kyul Kim et al

Posted on 07/12/2025 9:54:35 PM PDT by ConservativeMind

Diets rich in phosphate additives, commonly found in processed foods, can increase blood pressure by triggering a brain signaling pathway and overactivating the sympathetic nervous system that regulates cardiovascular function, researchers discovered. Their findings could lead to treatment strategies for patients with hypertension caused by overconsumption of foods containing high levels of phosphates.

"This research uncovers a previously unrecognized brain-mediated mechanism by which high dietary phosphate intake promotes hypertension and sympathetic overactivation, highlighting central fibroblast growth factor receptor signaling as a novel therapeutic target," said Han Kyul Kim, Ph.D.

Inorganic phosphate is often used as a preservative or flavor enhancer in packaged foods, processed meats, and other dietary staples. As a result, the study reports, the average adult in developed countries consumes phosphate far above the recommended daily allowance.

Following excessive phosphate intake, circulating fibroblast growth factor-23 (FGF23) can enter the brain and induce hypertension, Dr. Kim and his colleagues report in their study. The research outlines a new paradigm for this previously unclear mechanism and identifies a potential target for developing treatment strategies.

Hypertension occurs when the pressure that pushes against a patient's arterial walls is too high.

Researchers ran a series of tests that measured and compared FGF23 protein levels, mean arterial pressure, and renal sympathetic nerve activity in rats receiving a high (1.2%) phosphate diet and another group on a normal (0.6%) phosphate diet. The measurement was repeated during stress response to exercise by stimulation of the spinal cord.

Researchers found that those on the high phosphate diet showed increased levels of FGF23 protein in their serum, cerebrospinal fluid, and brain stem, and that FGF23 proteins were able to cross the blood-brain barrier, causing high blood pressure both at rest and during physical stress.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: diet; food; hypertension; nutrition; phosphate; processed
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Phosphates higher than normal appear to increase blood pressure through now identified pathways.

Don’t eat processed meats.

1 posted on 07/12/2025 9:54:35 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; jy8z; ProtectOurFreedom; matthew fuller; telescope115; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 07/12/2025 9:55:03 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Also damages the kidneys, my sister found out to her dismay.


3 posted on 07/12/2025 9:57:59 PM PDT by Jonty30 (He was so fat that it took a year for his memory foam mattress to forget him. )
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To: ConservativeMind

Anything PHOS-— should be avoided.


4 posted on 07/12/2025 9:59:42 PM PDT by LittleBillyInfidel (This tagline has been formatted to fit the screen. Some content has been edited.)
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To: ConservativeMind

I just got a hankering for a rotisserie chicken from walmart...


5 posted on 07/12/2025 10:07:08 PM PDT by waterhill (Nobody cares, work harder!)
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To: waterhill

Is canned tuna safe?


6 posted on 07/12/2025 10:15:38 PM PDT by Blue Highway
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To: Jonty30

Is it something RFKjr is trying to get rid of?


7 posted on 07/12/2025 10:34:14 PM PDT by Flaming Conservative ((Pray without ceasing))
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To: ConservativeMind
CategoryExamplesNotes/Why High in Inorganic Phosphate
Processed MeatsBacon, bologna, chicken nuggets, deli meats (e.g., ham, sausages), hot dogs, processed beef, lamb, pork, and chicken productsOften injected or marinated with phosphate additives to retain moisture and prevent discoloration.
Dairy ProductsProcessed cheeses (e.g., American cheese, cheese spreads, block cheese products), macaroni & cheese, alfredo sauce, pudding, non-dairy creamers, milkshakes, ice cream barsContain added phosphates like disodium phosphate for thickening and preservation.
BeveragesCola and pepper-type sodas, bottled iced teas, fruit punch, energy or sports drinks, flavored waters, powdered drink mixes, beer, winePhosphoric acid and other phosphate salts are added for flavor and acidity.
Baked Goods and MixesPackaged breads, cakes, cookies, pastries, donuts, pancake and waffle mixes, quick bread mixes, bran muffinsLeavening agents like sodium acid pyrophosphate are commonly added.
Fast and Convenience FoodsPizza, frozen meals, canned fish, cheesy snacks, cereals, chocolate and caramels, bran cerealsProcessed for longer shelf life with additives like monopotassium phosphate.
SeafoodSome frozen or processed seafood (e.g., scallops, shrimp with additives)Phosphate salts added to prevent drying out and improve appearance.

8 posted on 07/12/2025 11:29:27 PM PDT by ProtectOurFreedom (“Diversity is our Strength” just doesn’t carry the same message as “Death from Above”s)
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To: ProtectOurFreedom

That reads like my weekly menu.


9 posted on 07/13/2025 12:03:30 AM PDT by irishjuggler
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To: ProtectOurFreedom

Didn’t see MSG on there. Asians use it quite a bit. Ive started using it also. Makes things tasty.


10 posted on 07/13/2025 12:09:59 AM PDT by Pocketdoor
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To: ConservativeMind

My 17-year-old son has been harping on this several years


11 posted on 07/13/2025 12:12:10 AM PDT by wardaddy ( The Blob must be bled dry but don’t hold your breath )
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To: ConservativeMind

Does that mean beef jerky and slim Jims are off the menu?


12 posted on 07/13/2025 12:21:20 AM PDT by Bullish (My tagline ran off with another man, but it's ok---- I wasn't married to it.)
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To: Bullish

Oh yeah. Kiss that stuff good bye.

“The truly fun things in life are either illegal, immoral or fattening’’.- W,C, Fields.


13 posted on 07/13/2025 1:14:18 AM PDT by jmacusa (Liberals. Too stupid to be idiots.)
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To: waterhill
And biscuits for the gravy.
14 posted on 07/13/2025 1:15:05 AM PDT by jmacusa (Liberals. Too stupid to be idiots.)
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To: ProtectOurFreedom

Something as American as hot dogs?


15 posted on 07/13/2025 1:17:34 AM PDT by jonrick46 (Leftniks chase illusions of motherships at the end of the pier.)
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To: ConservativeMind

16 posted on 07/13/2025 1:35:17 AM PDT by Larry Lucido
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To: ProtectOurFreedom

my common foods seem to be the problem:
- deli meat (turkey)
- canned fish (tuna)
- hotdog
- cheese
- bread
- grits (oatmeal?)
- diet soda
- fruit punch... cranberry juice?
- pizza

it doesn’t leave much to eat:
- potato
- rice
- beans
- fresh vegetables
- steak
- chicken
- water

‘chicken products’... i’m guessing that doesn’t include fresh chicken breast.

turns out the standard New England ‘meat & potatoes’ is the way to go


17 posted on 07/13/2025 3:13:42 AM PDT by sten (fighting tyranny never goes out of style)
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To: jmacusa

Eating for content ant not taste is the key. Yet a lot of healthy things are very delicious; eggs, bacon, grass fed meats...


18 posted on 07/13/2025 3:25:27 AM PDT by Bethaneidh
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To: Pocketdoor

I don’t see an end of Sarcasm symbol on your comment.

If you’re actually serious, please do some research on MSG. It has many different names to try to fool us.


19 posted on 07/13/2025 3:41:50 AM PDT by Freee-dame
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To: ProtectOurFreedom

You know i have a cook book from my local county extention office that shows how to make homemade quick mixes.

No additives.

Used it when I had a house full.

Also would make good gifts


20 posted on 07/13/2025 4:49:34 AM PDT by Chickensoup
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