Free Republic
Browse · Search
General/Chat
Topics · Post Article

Skip to comments.

The Great Aspirin Debate: Why Age-Based Guidelines Are Being Questioned
Study Finds ^ | April 02, 2025 | Staff

Posted on 04/02/2025 7:19:48 PM PDT by Red Badger

(Photo by Shane Maritch on Shutterstock)

In a nutshell

* Current guidelines restricting aspirin based on age alone may be flawed; researchers argue decisions should be based on individual cardiovascular risk rather than arbitrary age cutoffs.

* The ASPREE trial that led to age-based restrictions was terminated early and used unusual endpoints, making it an “uninformative” basis for sweeping guideline changes.

* Patients with higher cardiovascular risk (above 10% over 10 years) may benefit from aspirin regardless of age, and should discuss individual risks and benefits with their healthcare provider.

*************************************************************************************

BOCA RATON, Fla. — For decades, aspirin has been a cornerstone of heart disease prevention. But recent guidelines advise against daily aspirin for adults over 60 or 70. Now, a provocative new paper challenges these recommendations, calling them “misinformed” and based on questionable evidence.

Researchers from Florida Atlantic University argue that doctors should consider each patient’s individual risk profile rather than applying blanket age cutoffs when it comes to aspirin. With cardiovascular disease killing nearly 18 million people worldwide annually, these recommendations affect millions of older adults who might benefit from this inexpensive medication.

“The reliable evidence indicates that, to do the most good for the most patients in primary prevention of heart attacks and strokes, health care providers should make individual clinical judgments about prescribing aspirin on a case-by-case basis and based on benefit-to-risk not just age alone,” said co-author Dr. Charles H. Hennekens, a professor of medicine and preventive medicine at FAU’s Schmidt College of Medicine, in a statement.

The Controversial ASPREE Trial: What You Should Know

The debate centers on a major study called ASPREE (Aspirin in Reducing Events in the Elderly), which examined aspirin use in adults 70 and older. The trial was stopped early after just four years—despite being planned for 12 years—and showed slightly higher mortality in the aspirin group.

These findings prompted the American Heart Association/American College of Cardiology to recommend aspirin only for patients under 70, and the U.S. Preventive Services Task Force later restricted it further to those under 60.

But Wittes and colleagues identify several problems with this influential trial:

ASPREE used an unusual combined endpoint (death, dementia, and disability) different from standard heart outcomes used in previous aspirin studies

The trial’s early termination may have prevented detection of benefits that emerge with longer treatment The unexpected finding of increased cancer deaths contradicts previous evidence suggesting aspirin might protect against certain cancers

In their paper, published in the journal Clinical Trials, researchers outline why they believe that both guideline committees were “unduly influenced by the uninformative, not null, results of the ASPREE trial.” As Hennekens notes, “It seems counterintuitive among patients taking aspirin long term to stop it just because a birth milestone is reached. Finally, absence of evidence does not equate to evidence of absence of effect.”

Risk vs. Age: A Better Approach to Aspirin Decisions

About 40% of American adults over 40 have metabolic syndrome—a combination of obesity, high blood pressure, abnormal cholesterol, and insulin resistance. These individuals face a 16-18% ten-year risk of heart problems, making them likely candidates for aspirin’s benefits. Yet under current guidelines, those over 60 or 70 are advised against it based solely on age.

Instead, the researchers propose that cardiovascular risk should determine who takes aspirin. For people with a 10-year cardiovascular risk above 10%, aspirin’s benefits typically outweigh its risks, regardless of age.

The authors emphasize that aspirin should complement lifestyle changes and medications like statins—not replace them. Doctors should weigh individual risk factors and potential benefits, considering age as just one factor among many.

Why Guidelines Matter

This debate highlights a fundamental tension in modern medicine: simple rules versus personalized care. Age-based cutoffs are easy to remember but may not serve all patients well. More tailored approaches potentially provide better care but require more time and clinical judgment.

For patients, especially those over 60 with multiple heart risk factors, this controversy creates uncertainty. Should they follow official guidelines or pursue a more individualized approach?

“While patient preference is always important to consider in decision-making, this assumes even greater relevance among patients in whom the absolute benefits and risks of aspirin are similar,” said Hennekens. “Patient preference may include consideration of whether the prevention of a first heart attack or stroke is more important consideration to them than their risk of a significant gastrointestinal bleed.”

The researchers argue that each patient deserves careful assessment of their specific situation—regardless of age. For a 75-year-old with several risk factors and low bleeding risk, daily aspirin might still make sense despite current guidelines.

“Guidelines for aspirin in primary prevention do not seem to be justified,” said Hennekens. “As is generally the case, the primary care provider has the most complete knowledge about the overall benefits and risks for each patient and should make individual clinical decisions.”

According to the U.S. Centers for Disease Control and Prevention, more than 859,000 Americans die of heart attacks or stroke every year, accounting for more than one-third of all U.S. deaths. These diseases take an enormous economic toll, costing $213.8 billion annually to the healthcare system and $137.4 billion in lost productivity from premature death alone.

The debate continues about aspirin’s role in preventive care, but one thing remains certain: this inexpensive pill still generates remarkable controversy. And like the research behind it, these decisions rarely fall into simple categories—they exist in shades of gray, requiring careful thought rather than rigid rules.

Paper Notes

Study Limitations

The authors acknowledge several constraints to their critique. They don’t present new clinical data, instead relying on previously published trials and meta-analyses. Their argument partly depends on the quality of these previous studies, which have their own limitations. Additionally, the authors don’t provide detailed quantitative analysis of exactly how much benefit older adults might get from aspirin or precisely which older adults would benefit most. Their argument focuses more on principles of evidence interpretation and guideline development rather than specific risk calculations or treatment algorithms. The paper also doesn’t address potential challenges of shifting from simple age-based guidelines to more individualized risk assessment approaches.

Funding and Disclosures

The authors declare they received no financial support for their article. However, they disclose various relationships with pharmaceutical companies and research organizations. Several authors serve as consultants or advisory board members for pharmaceutical companies, and some chair data monitoring committees for clinical trials. The authors specifically note they hold no stock in any pharmaceutical or medical device company. These disclosures support transparency, allowing readers to assess potential conflicts that might influence the authors’ perspective on aspirin use.

Publication Information

The article “Aspirin in primary prevention: Undue reliance on an uninformative trial led to misinformed clinical guidelines” was published in Clinical Trials in 2025.

The authors include Janet Wittes, David L. DeMets, KyungMann Kim, Dennis G. Maki, Marc A. Pfeffer, J. Michael Gaziano, Panagiota Kitsantas, Charles H. Hennekens, and Sarah K. Wood, representing various institutions including Florida Atlantic University, University of Wisconsin-Madison, Harvard Medical School, Brigham and Women’s Hospital, and the VA Boston Healthcare System.

The paper presents a scholarly critique rather than original research, focusing on how clinical trial evidence is interpreted and translated into practice guidelines.


TOPICS: Health/Medicine; History; Military/Veterans; Society
KEYWORDS:

1 posted on 04/02/2025 7:19:48 PM PDT by Red Badger
[ Post Reply | Private Reply | View Replies]

To: Red Badger
“The reliable evidence indicates that, to do the most good for the most patients in primary prevention of heart attacks and strokes, health care providers should make individual clinical judgments about prescribing aspirin on a case-by-case basis and based on benefit-to-risk not just age alone,”

I can just see how popular this is going to be with doctors... not.

2 posted on 04/02/2025 7:27:29 PM PDT by Carry_Okie (The tree of liberty needs a rope.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Red Badger

This stop with low dose aspirin came out in 2022 at the height of medical chicanery and fraud and should be discounted.
The problem is that aspirin is cheap and doesn’t need a prescription. They want you on Plavix instead. The cost for Plavix 75 mg oral tablet is around $799 for a supply of 90 tablets.

This is the new trend. Women shouldn’t get pap smears, or mammograms, men shouldn’t get a PSA test, etc etc.

Big medicine has turned against us.


3 posted on 04/02/2025 7:29:06 PM PDT by DesertRhino (2016 Star Wars, 2020 The Empire Strikes Back, 2025... RETURN OF THE JEDI...)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Red Badger

And this anti-aspirin jihad started when aspirin was getting used for covid. They would ban it if they could. Or heavily restricted, like in Europe.


4 posted on 04/02/2025 7:43:08 PM PDT by DesertRhino (2016 Star Wars, 2020 The Empire Strikes Back, 2025... RETURN OF THE JEDI...)
[ Post Reply | Private Reply | To 1 | View Replies]

To: DesertRhino
The cost for Plavix 75 mg oral tablet is around $799 for a supply of 90 tablets.

If you get the name brand. If you get the generic it is about $18 for a 90 day supply. Still more costly then aspirin.

5 posted on 04/02/2025 7:46:50 PM PDT by Harmless Teddy Bear ( Not my circus. Not my monkeys. But I can pick out the clowns at 100 yards.)
[ Post Reply | Private Reply | To 3 | View Replies]

To: Red Badger

I was put on a full aspirin a day (plus other meds) when I was diagnosed with clot shot (I’m over 70). After a period of time I started getting bruising & some bleeding. I cut back to one small aspirin per day.

I had been on the daily for a year or more when I read a study that showed people could get by on one small aspirin every third day. That’s what I’m on now. I always run this past my providers.


6 posted on 04/02/2025 8:01:09 PM PDT by Cold Heart (It's a good time to be ashamed to be a democrat)
[ Post Reply | Private Reply | To 1 | View Replies]

To: DesertRhino

Not my experience. Several doctors want me on plavix but I am having brain bleeds so a few said think about aspirin . I need plavix but too scared to take because of the brain bleeds. If you don’t have an MRI you could be walking around with a brain that has brain bleeds and strokes and you don’t know it.


7 posted on 04/02/2025 8:01:52 PM PDT by RummyChick
[ Post Reply | Private Reply | To 3 | View Replies]

To: Cold Heart

I take on full aspirin a day. And yes, I noticed easier bruising. But I don’t think it’s serious.......


8 posted on 04/02/2025 8:04:59 PM PDT by Red Badger (Homeless veterans camp in the streets while illegals are put up in 5 Star hotels....................)
[ Post Reply | Private Reply | To 6 | View Replies]

To: Red Badger

The operative phrase in this study is “ primary prevention.”

The advice to not use aspirin was intended to apply to people taking it only to prevent a first event. The evidence weakly suggested that the risk of gastrointestinal bleeding outweighed the reduction of a first heart attack or stroke.
This article does not make it clear that in patients who have had a heart attack or stroke/TIA, that the benefit of aspirin greatly exceeds the risk. DO NOT STOP aspirin, regardless of age, if you have known cardiovascular disease!


9 posted on 04/02/2025 8:11:33 PM PDT by daifu (Texas MD)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Red Badger

Aspirin back and body works very well for aches and pains. I’ve never read about aspirin affecting the liver like Tylenol and ibuprofen. I take it more than those when needed.


10 posted on 04/02/2025 8:14:14 PM PDT by dandiegirl (BOBBY m)
[ Post Reply | Private Reply | To 8 | View Replies]

To: daifu

I had a mild heart attack and a quad by-pass in 2020..........


11 posted on 04/02/2025 8:19:05 PM PDT by Red Badger (Homeless veterans camp in the streets while illegals are put up in 5 Star hotels....................)
[ Post Reply | Private Reply | To 9 | View Replies]

To: Red Badger

We have used aspirin (willow bark) for literally thousands of years, with few, well-known side effects.

The newer drugs the pharmaceutical companies want us to take are questionable at best.

I’ll stick with my ASA, thanks.


12 posted on 04/02/2025 8:25:46 PM PDT by Don W (When blacks riot, neighborhoods and cities burn. When whites riot, nations and continents burn)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Red Badger

Was that a Dr. prescribed full dosage per day?

If you are bruising you can’t see what it’s doing to internal organs. You could cut back to a couple small ones spread through the day.

Everybody reacts differently to meds.


13 posted on 04/02/2025 8:32:00 PM PDT by Cold Heart (It's a good time to be ashamed to be a democrat)
[ Post Reply | Private Reply | To 8 | View Replies]

To: Red Badger
From the anecdotal standpoint, I have taken one regular 325 mg Dollar Tree aspirin every day since Sept. 2010, after having a craniotomy to remove a (benign) meningioma tumor, for which healing demanded keeping one's blood pressure low. This dosage was ordered by my primary internist who also prescribed blood-pressure-modifying medications valsartan + hydroChloroThiazide (diuretic) + metoprolol (pulse rate lowering).

Throughout, my cardiac reports have been excellent, with the diuretic discontinued, and the valsartan and metoprolol cut back to the lowest amounts available. But the amount of asporin has stayed the same. Reports of intensive tests by the cardiologist specialist have shown the heart function to be comparable to that of a healthy teen-age athlete.

I am now 88 and getting older day by day without false anxiety. But I do have a very good well-known brand of heart monitor device and use it regularly, keeping records to plot out the status week-by=week, month-by=month for the last 14 years.

A note:

for many years from the mid-forties my weight had been trending on the high side, inching up. At my wellness exam of Dec. 2019 my weight was up to 230 lb. So from that point, thiugh my heart function was still OK, I determined to practice prudence, being watchfful about my food rations -- but without "dieting" -- staying attentive by checking often, my weight was dropping little by little such that by 2022 ny weight was down to 180, and since that at this point it is now 160, with no pot belly for quite a while.

(Avoiding sugar- or corn-syrup-laden foods pretty strictly; stevia or a little honey sweeteners only; but lots of eggs and milk and butter all along.)

I don't see any reason to cease the regular dosage of aspirin. I hardly ever feel a need to resort to any other pain-lillers, not experiencing much (if any) regular muscle or head aches.

Be advised.

14 posted on 04/03/2025 2:21:56 AM PDT by imardmd1 (To learn is to live; the joy of living: to teach. Fiat Lux!)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Red Badger

I took the 81mg for probably 20+ years but quit about 8 years ago.


15 posted on 04/03/2025 4:27:29 AM PDT by maddog55 (The only thing systemic in America is the left's hatred of it!)
[ Post Reply | Private Reply | To 1 | View Replies]

To: imardmd1

Sounds like a very good plan...............


16 posted on 04/03/2025 4:32:03 AM PDT by Red Badger (Homeless veterans camp in the streets while illegals are put up in 5 Star hotels....................)
[ Post Reply | Private Reply | To 14 | View Replies]

To: Red Badger

A keeper article.


17 posted on 04/03/2025 4:43:23 AM PDT by Excellence (ANGRY, DAMNED-OLD, GUN-TOTIN' WOMAN FOR TRUMP)
[ Post Reply | Private Reply | To 1 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
General/Chat
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson