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Compound found in common herbs inspires potential anti-inflammatory drug for Alzheimer's disease
Medical Xpress / The Scripps Research Institute / Antioxidants ^ | March 10, 2025 | Piu Banerjee et al

Posted on 03/18/2025 4:16:57 PM PDT by ConservativeMind

The herb rosemary has long been linked with memory. So it is fitting that researchers would study a compound found in rosemary and sage—carnosic acid—for its impact on Alzheimer's disease.

Carnosic acid is an antioxidant and anti-inflammatory compound that works by activating enzymes that make up the body's natural defense system. Scientists have now synthesized a stable form, diAcCA. This compound is fully converted to carnosic acid in the gut before being absorbed into the bloodstream.

The research showed that when diAcCA was used to treat mouse models of Alzheimer's disease, it achieved therapeutic doses of carnosic acid in the brain and led to enhanced memory and synaptic density, or more synapses in the brain. Because the decline of neuronal synapses is also closely correlated to dementia in Alzheimer's disease, this approach could counteract the progression of cognitive decline.

Analysis of tissue samples showed the drug also markedly decreased inflammation in the brain. This unique drug is activated by the very inflammation that it then combats and thus is only active in areas of the brain undergoing inflammatory damage.

"We actually increased the number of synapses in the brain," says Stuart Lipton, MD, Ph.D. "We also took down other misfolded or aggregated proteins such as phosphorylated-tau and amyloid-β, which are thought to trigger Alzheimer's disease and serve as biomarkers of the disease process."

Lipton's group treated mouse models with the compound over the course of three months.

"We did multiple different tests of memory, and they were all improved with the drug," Lipton says. "And it didn't just slow down the decline; it improved virtually back to normal." Analysis of tissues also showed increased neuronal synaptic density and decreased formation of phosphorylated-tau aggregates and amyloid-β plaques.

The mice tolerated diAcCA well.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: alzheimers; carnosicacid; cognitivedecline; herbs; inflammation; memory; memoryloss; rosemary; sage; synapses
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To: Veto!

a simple tea of honey and a couple of sage leaves is delicious

sage = wisdom


21 posted on 03/18/2025 5:55:32 PM PDT by SisterK (to do justly, to love mercy and to walk humbly)
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To: ConservativeMind

22 posted on 03/18/2025 6:42:53 PM PDT by jonrick46 (Leftniks chase illusions of motherships at the end of the pier.)
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To: FreedomPoster

I have a nice rosemary plant and used small twigs of it as a sherb in cooking no problem..The plant/bush got very large I cut it back and hand carried trimmings to trash..I had a serious allergy attack from head to toe red welts..my throat closed up could not eat solid food...could not sleep constant coughing up mucus..my regular doc on vacation so i toughed it out with otc medication i was miserble lost 9 pounds trouble breathing..finally got over it in about 4 weeks...replacement doc said they didnt do allergy tests for rosemary which i dont believe...anyway just strange not allergic to herb in food but contact allergy was unreal and bad...


23 posted on 03/18/2025 6:56:50 PM PDT by rolling_stone
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To: montag813; Diana in Wisconsin; little jeremiah; SunkenCiv; ConservativeMind
Montag813

Hestias Kitchen a Sprig of Rosemary

snip...

"A Wedding Essential"

Rosemary has a happier association with weddings. It was used to help remember the wedding vows and rosemary was sometimes dipped into the cups of the bridal couples so they could toast each other. Rosemary was considered to promote faithfulness and a bride would often give her groom a sprig to hold on their wedding night. Dried rosemary was also added to the wedding night bed linen.

Wealthy couples often gave it as wedding favours, the end dipped in gold, then tied with ribbons. It also appeared in bridal wreaths to symbolise love, faithfulness, friendship and kind remembrance of the family she would be leaving behind. Anne of Cleves even wore it at her wedding to Henry VIII, she didn’t lose her head and remained friends with Henry even after the marriage was ended. Perhaps it brought her some luck?

"There’s rosemary, that’s for remembrance; pray you, love, remember. And there is pansies, that’s for thoughts. -William Shakespeare (Hamlet, Act 4, Scene 5)"

So in this instance a very ironic bittersweet use of rosemary. Ophelia hoped to marry Hamlet but Hamlet kills her Father Polonius. Ophelia goes mad at death of father by her love, loses her mind and drowns herself in a stream. In the quote above she is talking to Hamlet in her madness.

24 posted on 03/18/2025 7:00:38 PM PDT by Pete from Shawnee Mission ( )
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To: Pete from Shawnee Mission

Thank you! Excellent.


25 posted on 03/18/2025 7:05:30 PM PDT by montag813
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To: Diana in Wisconsin

Diana; The Queens coffin held more flowers than any floral border I ever planted! (I think I see some Lavender tucked away in there too!) OF course, she was the symbol for an Empire and did have some resources I do not.

(My English G Grandfather’s Army Discharge papers from the 7th Cav list his occupation at time of enlistment in Beaver Dam as “Gardener”.)


26 posted on 03/18/2025 7:12:02 PM PDT by Pete from Shawnee Mission ( )
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To: ConservativeMind

CM. Thanks! I will plant more rosemary this year!


27 posted on 03/18/2025 7:30:39 PM PDT by Pete from Shawnee Mission ( )
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To: SisterK

No tea bags? I have green tea bags on the shelf. Maybe black tea too. Green tea allegedly kills cancer cells. Taste ok with sage?


28 posted on 03/18/2025 8:06:04 PM PDT by Veto! (Trump Is Superman)
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To: ConservativeMind

Scripps is serious.

They just took patents on this stuff.

Looks real to me.


29 posted on 03/18/2025 8:25:33 PM PDT by Uncle Miltie (Islam’s Strategy is Effective: Out-breed and murder everyone else. What to do?)
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To: rolling_stone

Wow, that’s crazy! Yeah, they can get big and ugly. I used to replace them every 4-5 years, but never had any issues like that.


30 posted on 03/18/2025 8:30:08 PM PDT by FreedomPoster (Islam delenda est)
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To: Paperpusher

I have thought that Alzheimer’s was caused by a prion, similar to the prion that causes mad cow.
~~~~~

Yes, I believe a UCSF group discovered that a succession of two specific prions is associated with Alzheimer’s. More recent research indicates that the body’s immune reaction to the prions might be more closely associated with forming Alzheimer’s plaque.


31 posted on 03/18/2025 8:57:05 PM PDT by nagant
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To: Pete from Shawnee Mission

I obviously need rosemary tea!


32 posted on 03/18/2025 9:21:01 PM PDT by little jeremiah (https://qalerts.app/)
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To: Veto!

I have not tried sage with green or black tea so I cannot say if it is tasty or not
I tend to drink tea and coffee first thing in the morning
no caffeine during the day
so I have the rest of the day to experiment with herbal teas
growing a tiny “medicine garden”


33 posted on 03/19/2025 4:51:14 AM PDT by SisterK (to do justly, to love mercy and to walk humbly)
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To: Pete from Shawnee Mission

Awww! I want that on my Death Certificate. ;)


34 posted on 03/19/2025 6:50:22 AM PDT by Diana in Wisconsin (I don't have, 'Hobbies.' I'm developing a robust Post-Apocalyptic skill set.)
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To: ConservativeMind

Ok, it’s gonna be baked onions seasoned with rosemary and sage more often.


35 posted on 03/19/2025 8:25:21 AM PDT by bgill
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To: FreedomPoster

Edison Lighthouse’s Rosemary?


36 posted on 03/19/2025 8:27:06 AM PDT by bgill
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To: Diana in Wisconsin
Awww! I want that on my Death Certificate. ;)

What I want on my tombstone is this:

0x00000012 0x000000DF 0x000000FC
0x0000000A 0x00000A3F 0x00000045
Process Unexpectedly Terminated

37 posted on 03/19/2025 8:27:35 AM PDT by Lazamataz (I'm so on fire that I feel the need to stop, drop, and roll!)
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To: rolling_stone

Wonder if there was a sprig of something else growing in the rosemary bush. Maybe poison ivy.

Mother has a big rosemary bush I gather from and for years have said I need to start some at our house.


38 posted on 03/19/2025 8:34:51 AM PDT by bgill
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To: Pete from Shawnee Mission

May Charles’ not have any rosemary.


39 posted on 03/19/2025 8:39:06 AM PDT by bgill
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To: Lazamataz

40 posted on 03/19/2025 9:21:06 AM PDT by Diana in Wisconsin (I don't have, 'Hobbies.' I'm developing a robust Post-Apocalyptic skill set.)
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