Posted on 02/11/2025 7:34:36 PM PST by ConservativeMind
A dietary supplement has been found to stop the progression of heart failure in animal models.
The paper has shown that feeding mice a diet that included this supplement, elevated energy-boosting, anti-oxidant fats that circulate in our blood, called plasmalogen lipids, which restores the integrity of damaged cells in a failing heart.
Plasmalogens make up about 15% of cell membranes—the outer layer of cells—and are predominantly found in the brain and heart.
Disruptions to the cell membrane can change the composition of the lipids within cells and that can contribute to and exacerbate the seriousness of diseases including obesity, neurological and cardiovascular diseases, Teleah Belkin said.
"A heart with cardiomyopathy—or heart failure—has reduced levels of plasmalogens," Belkin said. "What we found was that the dietary supplement was able to restore cardiac function and lessen other pathological features associated with heart failure."
Earlier Baker Institute trials using variations of this dietary supplement have already shown the therapeutic potential of enhancing plasmalogen levels in preclinical models of atherosclerosis, fatty liver disease and even in obese human study participants, but this is the first study that shows this plasmalogen-modulating dietary supplement has therapeutic potential for the heart, lungs and kidneys in a preclinical model of dilated cardiomyopathy.
"We showed that when we elevated circulating and cardiac plasmalogens with this dietary supplement in mice with heart failure, remodeling of the lipid composition in the heart occurred, reducing the negative effects associated with cardiomyopathy, including tissue scarring and impaired mitochondrial properties, which are crucial for producing energy for the heart," Dr. Tham said.
Plasmalogens can be found naturally in foods, including mussels, scallops and octopus, and even strawberries, but you would have to consume large quantities of these food items to potentially receive the health benefits.
(Excerpt) Read more at medicalxpress.com ...
Sea squirts are available at some Asian supermarkets.
Bkmk
"Human clinical trials to test the efficacy of the patented supplement on a range of health outcomes, including arterial function, lipid metabolism and inflammation, will start in late 2025, and there are hopes that the supplement will be available sometime within the next two years."
I went to USPTO and could find no patents containing "plasmalogen." Interestingly, the Juvenescence web site says they are evaluating plasmalogen for treating Alzheimer's Disease: "Brain penetrant plasmalogen precursor targeting a core driver of neurodegeneration."
bttt
Bump
Starting to wonder about medicalxpress.com. This reads like an ad. Click here to find out...use the promo code BS...
When I know very little about something, I start with wikipedia.
They describe the taste of sea squirt as “rubber dipped in ammonia.”
I’m not sure I even need to know more.
Advertising scam.
Amazon has capsules. Very expensive.
Capsules of an Asian worm, eww. Anyway, who can trust capsules these days? Most dietary supplements have “China” in small print on the label.
It’s messy and time consuming (like my kitchen) but we should probably stick to local produce.
Here in PA the nearest thing to a sea squirt is a portobello mushroom. :(
Bkmk
I think I could get by on a diet of mussel, oysters, octopus and strawberries.
Well, the heart is a muscle, so it makes sense to eat mussels..............
C.M. This is a Brave Search aggregator summary:
Krill Oil Lipids
Plasmalogen lipids are a unique class of membrane glycerophospholipids containing a fatty alcohol with a vinyl-ether bond at the sn-1 position, and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone.
These lipids play critical roles in memory, focus, and cognitive functions. They are most abundant in the brain and are essential for their critical roles in memory, focus, and cognitive functions.
Krill oil is a rich source of plasmalogens, along with shark liver oil.
In studies, krill oil supplementation has been shown to improve plasma lipid parameters, including reducing plasma triacylglycerol levels and improving related lipoprotein particle concentrations. Additionally, krill oil supplementation can enhance the fatty acid composition in plasma and red blood cells, increasing the levels of EPA and DHA.
Research indicates that krill oil, due to its phospholipid content, can more effectively incorporate omega-3 fatty acids into plasma compared to fish oil.
This is particularly significant because plasmalogens play a role in anti-inflammatory responses, which might be linked to the significant decrease in pro-inflammatory cytokines observed in studies involving krill oil supplementation.
In summary, krill oil is a beneficial dietary supplement for enhancing plasmalogen levels, which can positively impact cognitive functions and reduce inflammation.
Interesting, thanks
The supplement may be Fruit Loops.
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