Case study describes potential breakthrough in treatment of aggressive type of prostate cancer

Researchers have published a case report that signifies a potential breakthrough in the treatment of an aggressive type of prostate cancer.

The report centers around a 60-year-old Air Force Veteran diagnosed with stage four metastatic prostate cancer and the positive outcomes of being treated with trastuzumab deruxtecan (T-DXd), an antibody drug conjugate.

The patient did not respond to multiple lines of therapy and experienced persistent tumor progression. As a last resort, the researchers tested for HER2 by immunohistochemistry, which came back positive and the patient was treated off-label in February 2024 with T-DXd.

The antibody drug conjugate, which is FDA approved for the treatment of a variety of HER2-expressing solid tumors including breast cancer, has not been studied in prostate cancer.

Maneesh Jain treated this patient, which is the first known case of using T-DXd for prostate cancer treatment.

After four cycles of T-DXd, the patient showed a 57% overall reduction in tumor volume, including in the brain. His condition improved significantly, defying earlier prognoses that suggested a transition to hospice care due to a lack of treatment options. As of November 2024, the patient is clinically doing well. He has been on this therapy now for nine months, while the last three lines of treatment for his advanced prostate cancer worked only three to four months each.

"This case highlights the promising potential of T-DXd in treating prostate cancer patients, particularly in aggressive forms," said Jain. "It also underscores the importance of routine HER2 expression testing in advanced prostate cancer, which could help identify more patients who might benefit from targeted therapies like T-DXd."

A case report has highlighted the potential of trastuzumab deruxtecan (T-DXd) as a treatment for aggressive prostate cancer. A 60-year-old Air Force veteran with stage four metastatic prostate cancer, who had not responded to several therapies, showed significant improvement after being treated off-label with T-DXd in February 2024. This treatment, typically used for HER2-expressing cancers like breast cancer, was the first known use in prostate cancer. After four cycles, the patient experienced a 57% reduction in tumor volume and significant clinical improvement, defying previous expectations. The case underscores the importance of HER2 testing in advanced prostate cancer for identifying candidates for targeted therapies.

I would take it, but also get tested for HER2 and take that therapy.

Additionally, I have several research papers from Leslie C Costello, a scientist who found just 50mg of total zinc a day (normal Upper Tolerable Limit is 40 mg) with a zinc ionophore surpassed metastatic cancer in his patient, and let him further identify a high prolactin issue that, when treated, apparently cured the patient.

His paper, “Zinc: The Wonder Drug for the Treatment of Carcinomas” has a summary of this on page six of the PDF of this information on this PubMed page:

https://pmc.ncbi.nlm.nih.gov/articles/PMC7316362/

Subsequent to reading several of his papers, I started taking a zinc picolinate (22 mg) capsule a day, along with either two teabags of brewed green tea (or a 150 mg EGCG capsule) and a single quercetin capsule. I have a separate study showing EGCG can be nearly four times more effective than quercetin as a zinc ionophore. However, they appear to work differently, so I combine them and have a small amount of fat with it all to help it absorb.

The zinc ionophore Leslie uses is not commonly available, so I make do with easy alternatives. The need for a zinc ionophore is due to prostate cancer’s ability to greatly shut down the very pathways a normal cell uses to naturally get zinc in (ZIP transporters). The ionophores largely negate what the cancer is doing to save itself, and once the zinc gets in, it helps kill the bad cell.

Do note I am not a doctor and I’m just stating what I do and have come across in my reading.

Check out your total zinc and copper intake. If you have copper pipes, you might be getting upward of 1 milligram of copper a day from those alone, if you aren’t letting your water run a bit before drinking.

We do best with a 7.5 mg to 1 mg zinc to copper ratio.

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