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Vitamin K₂ reduces dreaded nighttime leg cramps in clinical trial
Medical Xpress / JAMA Internal Medicine ^ | Oct. 31, 2024 | Justin Jackson / Jing Tan et al

Posted on 11/01/2024 8:30:56 PM PDT by ConservativeMind

Researchers found that vitamin K2 supplementation reduces the frequency, intensity, and duration of nocturnal leg cramps (NLCs) in older individuals.

Approximately 50% to 60% of adults experience NLCs (sometimes referred to as a Charley horse) in their lifetime. There are no medical treatments without a substantial list of unpleasant side effects.

The multicenter, double-blind, placebo-controlled randomized clinical trial enrolled 199 individuals aged 65 years and older (mean age 72.3) who experienced two or more documented episodes of NLCs during a two-week screening period. Participants were randomly assigned in a 1:1 ratio to receive either vitamin K2 (menaquinone 7), 180 μg, or a placebo capsule daily for eight weeks.

The study's primary outcome was the mean number of NLCs per week between the vitamin K2 and placebo groups.

Secondary outcomes included the duration of muscle cramps measured in minutes and the severity of muscle cramps assessed using an analog scale ranging from 1 to 10.

At baseline, the mean number of NLCs per week was comparable in both groups, with 2.60 cramps in the vitamin K2 group and 2.71 in the placebo group.

During the eight-week intervention, the vitamin K2 group experienced a reduction in the mean weekly frequency of cramps to 0.96. In contrast, the placebo group maintained a mean weekly frequency of cramps at 3.63. A difference of 2.67 fewer cramps per week between the groups was statistically significant, and the trend was visible in just the first week.

The vitamin K2 group also significantly reduced NLC severity, with a mean decrease of 2.55 points compared to 1.24 points in the placebo group. The duration of NLCs decreased by a mean of 0.90 minutes in the vitamin K2 group, compared to 0.32 minutes in the placebo group. No adverse events related to vitamin K2 use were identified.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: cramps; legcramps; nightlegcramps; vitamink; vitamink2; vitamink2mk7
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They used vitamin K2 MK-7, 180 μg, and it reduced cramping by 2/3 over eight weeks of use.
1 posted on 11/01/2024 8:30:56 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

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2 posted on 11/01/2024 8:31:37 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

We were told to keep tracing the sign of the cross over it and it would go away. Worked every time.


3 posted on 11/01/2024 8:34:38 PM PDT by P.O.E. (Pray for America.)
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To: ConservativeMind

.


4 posted on 11/01/2024 8:56:43 PM PDT by Entropy Squared (The Rush to Chaos)
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To: ConservativeMind

I suffer from them relentlessly. I also take K2. I guess they could be worse
That’s hard to imagine.


5 posted on 11/01/2024 9:01:26 PM PDT by AuntB (Trump is our Ben Franklin - Brilliant, Boisterous, Brave and ALL AMERICAN!)
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To: ConservativeMind

Leg cramps are awful and the ones in the thighs the worst.
However, I have found applying theraworks (which I believe is essentially a topical epsom salt) will stop or prevent leg cramps.


6 posted on 11/01/2024 9:13:04 PM PDT by Williams (Let's Focus On Electing President Trump)
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To: AuntB

Highly recommend Theraworks. Plus I take magnesium and potassium supplements.
Also, applying a pretty heavy duty vibrating massager to the muscle will stop them, pressing hard into the muscle. Without the massager, you can press your knuckles into it.
Unfortunately, the pressure needed on the muscle is painful, and nothing prevents the muscles from being very sore for days after the cramping. However, a hot epsom salt bath for 15-20 minutes can help.


7 posted on 11/01/2024 9:17:34 PM PDT by Williams (Let's Focus On Electing President Trump)
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To: AuntB

You might want to try a magnesium supplement...say every other day (not over doing it). Daily intact for a male is 420 mg...for a gal, 320.

Into my 40s...I suffered a lot from it. After I started the magnesium, it went down to once a year.


8 posted on 11/01/2024 9:24:20 PM PDT by pepsionice
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To: ConservativeMind

It’s also supposed to be very good for getting calcium back into the bones.


9 posted on 11/01/2024 9:24:30 PM PDT by metmom (He who testifies to these things says, “Surely I am coming soon.” Amen. Come, Lord Jesus”)
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To: ConservativeMind

But all patients experienced blood clots since vitamin. K is needed to make clotting factors? Hope they checked for that..


10 posted on 11/01/2024 9:36:30 PM PDT by Getready (Wisdom is more valuable than gold and harder to find.)
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To: P.O.E.

Not for me. I take Vitamin K and sometimes the leg cramps are so bad it is like my feet will curl up


11 posted on 11/01/2024 9:39:31 PM PDT by madison10
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To: pepsionice

“You might want to try a magnesium supplement...say every other day (not over doing it). Daily intact for a male is 420 mg...for a gal, 320.”

Magnesium Glycinate 200mg at CVS or other local phamacy.


12 posted on 11/01/2024 9:54:25 PM PDT by WeaslesRippedMyFlesh (there will come a day when FR rejects articles from the NYT, et al. as "Commie trash, no thank you")
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To: pepsionice

I wouldn’t worry too much about “overdoing it”, and it depends a lot on what form of Mg you take because the absorption varies considerably. I take two 500 milligram magnesium oxide each day (poorly absorbed but keeps things moving) and one 400 milligram magnesium glycinate (absorbed much better). And K2 also and still occasionally get calf cramps, which seems to have more to do with my legs getting cold at night than anything else.


13 posted on 11/01/2024 9:57:41 PM PDT by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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To: madison10

You should go to Vit. K2 and hopefully it will do better.
I hope it works for you.


14 posted on 11/01/2024 9:59:20 PM PDT by laplata (They want each crisis to take the greatest toll possible.)
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To: ConservativeMind
I get them, my Doc called them restless leg syndrome (RLS). Tried lots of things, best thing seems to be exercising a few times a week on my bicycle. Everything else doesn't seem to help.
15 posted on 11/01/2024 10:02:24 PM PDT by Bullish (Socialism is a weed that blooms into communism, the tyranny that strangles liberty.)
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To: Bullish

RLS is a lot different from cramps. Gabapentin and dopamine agonists often used to treat.


16 posted on 11/01/2024 10:05:53 PM PDT by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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To: pepsionice

I take K2 and Magnesium and still get them. I’ve found drinking an ounce or 2 of pickle juice nightly helps A LOT. If I go any time without drinking the juice and get one, I immediately down a few ounces of juice and it goes away.


17 posted on 11/01/2024 10:19:31 PM PDT by peggybac (“You can avoid reality, but you cannot avoid the consequences of avoiding reality.” - Ayn Rand)
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To: steve86
Notice the ‘syndrome’ in the RLS. Anytime something's called a syndrome seems to mean they don't know what's causing it exactly and could be alot of things. As my Doc tells me.

My cramps can be extremely intense mostly during the night when asleep but they have also come on in the middle of the day too at times. They seem to have subsided quite a bit with regular exercise.

18 posted on 11/01/2024 10:28:06 PM PDT by Bullish (Socialism is a weed that blooms into communism, the tyranny that strangles liberty.)
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To: AuntB

I use a topical magnesium oil spray, Cymbiotika, before I go to bed. I spray it on my legs, my neck and shoulders and stomach. I take magnesium and vitamin K2 as well; I upped my intake over the summer and added the magnesium oil and I really think it has helped.


19 posted on 11/01/2024 10:33:25 PM PDT by FrdmLvr
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To: Bullish

I had RLS at one point caused by a medication. Annoying as hell but unrelated to cramps.


20 posted on 11/01/2024 10:43:54 PM PDT by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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