Posted on 10/03/2024 5:37:05 PM PDT by nickcarraway
Researchers say antibiotics given in infancy can disrupt development of the microbiome, resulting in increased levels of aggression later in life.
Giving antibiotics to young mice is likely to make them more aggressive in later life, according to a new study.
Researchers at Bar-Ilan University in Ramat Gan, central Israel, believe their findings could well apply to humans as well.
They say there is a significant link between antibiotics – medication used to treat bacterial infections – and the diverse microorganisms of the gut, known as the microbiome.
Antibiotics given in infancy can disrupt the development and limit the diversity of the microbiome, they say, resulting in increased levels of aggression.
The study used “humanized” mice that had been implanted with intestinal bacteria from infants who had received antibiotics shortly after birth.
“This approach enhances the relevance of the findings to human health and behavior, providing insights into how early-life antibiotic exposure can shape future social behaviors,” they explained in a news release.
The researchers measured aggression levels by introducing a foreign mouse into the home cage of a resident mouse and observing its reactions.
“Our findings are revolutionary,” said Prof. Omry Koren, who led the study at BIU’s Azrieli Faculty of Medicine with graduate student Atara Uzan-Yuzari. “They suggest that a disrupted microbiome during critical developmental periods can lead to persistent aggressive behaviors later in life.”
This opens up new avenues for understanding how early-life interventions could influence long-term behavioral outcomes and for developing strategies to mitigate these effects.
The study, published in the journal Brain, Behavior, and Immunity, builds on previous experiments carried out on fruit flies. Using mice, especially those implanted with the human microbiome, takes the investigation a step further, examining behavioral, biochemical and neurological changes.
“This study sheds light on the role of the gut microbiome in modulating aggression and highlights its potential avenues of action, offering insights for development of therapeutic strategies for aggression-related disorders,” say the authors.
The study was funded by a European Research Council grant.
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aggression has been around since the days of Cain.
and celebrated in the old testament (aka “The handbook for psychopaths”) for a long time.
Some still subscribe to that point of view.
I was wondering when you’d post a good mouse article.
Anti biotics are a double edged sword. If we were to run out of them, life would get a lot more dicey.
So, what happens to mice given the quackcine?
Doxy really helps my inflammation. Probably brings down my mmp-9 . Definitely brings down Ldh but it is not something I can take long term.
doesn’t fit with what we are seeing in males- loads of kids given antibiotics for everything when young, but they turn into metrosexuals and soy boys later in life-
what’s mmp-9? is it an inflammatory marker?
New-born mice are referred to as "pups."
Regards,
Yes. When at an Eye Doctor you can ask for a rapid test. Might take more than the basic Eye Doctor office to have the test. You can also get a blood test. There is controversy over what level is considered too high on the blood test.
Supposedly the level was changed in the US without changing methodology but Europe has something closer to the original reference range.
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