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Evidence of inverse relationship between incidence of Alzheimer's disease and colorectal cancer
Medical Xpress / Proceedings of the National Academy of Sciences ^ | Sept. 17, 2024 | Bob Yirka / Xu, Shunjiang et al

Posted on 09/21/2024 12:38:10 PM PDT by ConservativeMind

A team of epidemiologists has shown experimental evidence of an inverse relationship between incidences of Alzheimer's disease and colorectal cancer.

The group found that mice with Alzheimer's-like symptoms were less likely than control colorectal mouse models to develop colorectal cancer.

For years, doctors have been noticing that people who develop Alzheimer's are less likely to develop certain types of cancers, mostly particularly, colon cancer. They have also noticed the reverse; colorectal patients seem to be less likely to develop Alzheimer's disease.

For this study, the researchers ran experiments with mice to find out whether an association exists.

The researchers administered drugs to lab mice to induce colorectal cancer. Some of the mice had Alzheimer's symptoms beforehand and some did not. The team found that the mice with Alzheimer's were less likely to develop colorectal cancer.

Next, the researchers gave mice with Alzheimer's symptoms stool transplants from healthy mice and then tried to give them colorectal cancer. They found that those who had received the stool transplant were just as likely as healthy mice to develop tumors.

The researchers also tested the gut bacteria of all the mice in the study and found that those with Alzheimer's symptoms also had higher levels of Prevotella, a genus of Gram-negative bacteria. They found the same to be the case with humans diagnosed with mild cognitive impairment. And they found that people with colorectal cancer had lower levels of Prevotella than people who did not have cognitive impairment.

The researchers then fed healthy mice lipopolysaccharides taken from Prevotella and found that it led to cognitive decline. Giving the same mice standard cancer treatment afterward resulted in the development of fewer tumors. This, the team contends, suggests that mice with less natural Prevotella are less prone to cognitive decline and more prone to colon cancer.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: alzheimers; cancer; cognitive; coloncancer; colorectalcancer; lipopolysaccharides; prevotella
It seems a “no-win situation,” but keeping yourself healthy could keep you from tending toward either extreme.
1 posted on 09/21/2024 12:38:10 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 09/21/2024 12:38:40 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind
The group found that mice with Alzheimer's-like symptoms were less likely than control colorectal mouse models to develop colorectal cancer.

How do mice with Alzheimer's-like symptoms behave? Do they forget where the cheese is? Or are they found wandering, aimlessly, through the maze? Or they do not come when their names are called? What?

3 posted on 09/21/2024 12:59:57 PM PDT by 4Runner (America has elected enough lawyer-presidents already. Just stop!)
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To: 4Runner

.😂😅😂😅😂😅😂😅 you made my day 🙋


4 posted on 09/21/2024 1:05:32 PM PDT by thesligoduffyflynns (loose lips sink ships)
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To: 4Runner

Very funny, thank you.


5 posted on 09/21/2024 1:09:20 PM PDT by devere
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To: 4Runner
How do mice with Alzheimer's-like symptoms behave?

Know the difference.

Sr. Gonzales is mentally alert. But Sr. Rodrigeuz is showing signs of what might be early onset Alzheimer's.


6 posted on 09/21/2024 1:23:48 PM PDT by Angelino97
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To: ConservativeMind

I could be a good example of this. In 2015 I was I was diagnosed with colon cancer and had it successfully treated, as is been shown by one more successful colonoscopy taken only about a month ago. I’m 81 and in spite of the number of problems, one I do not have is having lost any of my marbles.


7 posted on 09/21/2024 1:25:07 PM PDT by libstripper
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To: ConservativeMind

Well that’s cheerful news.


8 posted on 09/21/2024 1:31:46 PM PDT by OKSooner (Domestic animals for Trump.)
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To: ConservativeMind

I don’t trust articles with Chinese names.


9 posted on 09/21/2024 1:37:10 PM PDT by nwrep
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To: libstripper

My late mother had both. She passed away due to cancer before the Alzheimers could do its worst however. They did an operation but couldn’t get it all and it spread. I looked after her with Alzheimers for about 6 years before that.


10 posted on 09/21/2024 2:20:07 PM PDT by xp38
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To: xp38

I really lucked out with the cancer. Because I’m a type II diabetic I have a regular health screening about once every three months. My doctor found that I had an abnormally low hemoglobin level, thereby setting off a stool sample followed by a colonoscopy that discovered the stage II cancer. Shortly thereafter I had surgery that got everything and I am now clear of it, nine years later.


11 posted on 09/21/2024 2:54:11 PM PDT by libstripper
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To: ConservativeMind

A strong inverse correlation has long been known between Alzheimer’s and schizophrenia. And though they noted that schizophrenia patients have an overabundance of serum Nitrous Oxides, Alzheimer’s patients have very little or none. Even then they were careful to point out that correlation does not equal causation.

It’s also noteworthy that Sildenafil (Viagra) and Tadalafil (Cialis) tend to increase the amounts of serum NOs.


12 posted on 09/21/2024 3:11:18 PM PDT by yefragetuwrabrumuy ("All he had was a handgun. Why did you think that was a threat?" --Rittenhouse Prosecutor)
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To: ConservativeMind

I’d rather have cancer of the ass and choose my passing than being oblivious to the passage of time.

But I’m sure that they’ll have a pill/shot so people can soon do both under the illusion of ‘health’.

/s


13 posted on 09/21/2024 4:05:31 PM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: yefragetuwrabrumuy

Sildenafil (Viagra) and Tadalafil (Cialis) add: Losartan, Lipitor, and Metformin.

Those 4 drugs may just be a miracle combination. Even for healthy people. See the book Outlive.


14 posted on 09/21/2024 5:07:25 PM PDT by FreedomNotSafety
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To: FreedomNotSafety
Those 4 drugs may just be a miracle combination

... as a primer for schizophrenia?

15 posted on 09/21/2024 5:17:24 PM PDT by Tellurian (Any cleverness from a democrat is quickly invested in deception)
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