Posted on 07/29/2024 12:12:55 PM PDT by Red Badger
A single injection of a new, off-the-shelf stem cell therapy for knee osteoarthritis significantly improved pain and function for up to 12 months in 75% of participants involved in a clinical trial. The treatment also has the potential to halt the disease’s progression.
In 2020, 7.6% of the global population had the painful degenerative condition osteoarthritis, an increase of 132.2% in total cases since 1990. It’s expected that by 2050, cases will have increased by 74.9% for knee, 48.6% for hand, and 78.6% for hip osteoarthritis.
Current treatment includes pain relief, usually with non-steroidal anti-inflammatory drugs (NSAIDs), exercise as tolerated, and joint replacement surgery. No available treatment delays the progression of the condition, and long-term use of NSAIDs increases the risk of stomach ulcers, kidney failure, and stroke or heart attack. However, clinical trials of a new one-injection stem cell treatment for osteoarthritis, developed by the private Australian biotech company Magellan Stem Cells, have shown very promising results.
“Our research indicates that Magellan’s off-the-shelf donor stem cell treatment is safe and effective in improving joint function, reducing pain levels, and may have the potential to halt the progression of osteoarthritis,” said Associate Professor Julien Freitag, lead researcher and Magellan’s Executive Director and Chief Medical Officer.
MAG200 is a single injection of donor stem cells into the joint (an intra-articular injection). It’s considered an ‘off-the-shelf’ therapy because it uses donor, or allogeneic, stem cells rather than the patient’s own, the surgical harvesting of which is labor-intensive. Importantly, because the treatment uses mesenchymal stem cells – adult stem cells that can differentiate into other cell types – from adipose tissue or body fat, it doesn’t trigger an immune response.
(Excerpt) Read more at newatlas.com ...
Just researching this today. This doc argues that Platelet Rich Plasma (PRP) injections are just as effective and a lot less expensive than stem cell injections:
https://www.youtube.com/watch?v=zQuSVXQG9-U
My wife had one knee replaced 5 years ago. She had the shot in the other knee a few weeks ago. Eventually she’s going to have the other one replaced as well.
Thanks. I found that going low-carb/low oxalate helps, but not nearly enough.
I bought a new knee brace last week that is working for me now. It is a Copper Fit natural motion knee brace. Instead of the single hinge on each side support, there is a short middle section connected with 3 hinges. It is called a tri-pivot hinge designed to follow the natural motion of the knee. I can sleep with it with no pain.
How long did it take for the knee to feel almost normal again?
I’m facing the manual braking procedure....could you give me some details and how BAD it hurt...I assume.
How much was your knee degree, that made it necessary to get the procedure?
Adult......
To be successful and recover full use function they want you to be able flez fla and Ben’s 120 to the max 130 degrees. I was stck at 90 and unable to ride a bicycle for example. Couldn’t complete a full circle revolution with it. Healed too fast.
They knock you out, force it to bend fully to 130, breaking out the scar tissue bthen you resume daily abbreviated physical therapy until it stops trying to tighten up. A year or more?
Bttt
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