Posted on 06/20/2024 9:52:04 PM PDT by SeekAndFind
According to a recent study, these people have faster and more subtle immune responses than those who develop symptomatic COVID-19.
“These findings shed new light on the crucial early events that either allow the virus to take hold or rapidly clear it before symptoms develop,” Dr. Marko Nikolić, senior author of the study and honorary consultant in respiratory medicine at the University College London, said in the press release.
The study, published in Nature on Wednesday, was a human challenge study conducted by researchers from the UK and the Netherlands. It is the first of its kind wherein participants were deliberately exposed to SARS-CoV-2, the virus that causes COVID-19.
Researchers recruited 16 young, healthy participants under 30 for the study. None had comorbidities, and none had ever previously been infected with COVID-19 or vaccinated.
Before the study received peer review, a preprint of it was made available online in April 2023.
The 16 individuals responded to the virus exposure differently and were grouped accordingly.
The first group contained six symptomatic people. The study authors categorized them as having sustained infections.
People in the second group were asymptomatic but still tested positive for COVID-19 with PCR tests. These participants were categorized as having transient infections.
The third type of people were asymptomatic and continuously received negative COVID-19 PCR test results. The authors confirmed that these participants were infected but cleared their infections so rapidly that the infections were dubbed “abortive.”
The second and third groups, who had asymptomatic COVID-19, had faster or more subtle immune responses, according to the authors.
On Day 1, the authors detected immune cells that migrated to the nose—the site of infection—in the asymptomatic groups.
However, people who tested negative for COVID-19 recruited fewer immune cell types, while the COVID-19-positive group recruited all immune cell types.
Symptomatic people with sustained COVID-19 infections had slower and more systematic immune responses. These participants had all types of immune cells going into the nose on Day 5 rather than Day 1.
Individuals with high expression of specific genes, such as HLA-DQA2, “are better at preventing the onset of a sustained viral infection,” the authors wrote.
Other studies have shown that increased activity of HLA-DQA2 in the blood is associated with milder COVID-19 progression.
HLA-DQA2 is one of many human leukocyte antigen (HLA) genes. HLA genes make proteins displayed on the cell surface. When pathogens infect cells, HLA proteins signal to immune cells that they have been infected.
The authors said their data confirm that HLA-DQA2 activity protects against further production of SARS-CoV-2 virus in infected cells.
Only people with symptomatic COVID-19 displayed systematic interferon responses. Interferons are messengers of the immune system that help reduce or aggravate immune and inflammatory activities.
The authors were surprised to find that interferons in the blood were activated before those at the infection site. Interferon activity in the blood peaked on Day 3 of the infection; however, interferon activity at the infection site—the nose—was not detected until Day 5.
In the press release, the authors said that slow immune responses in the nose could have allowed the infection to establish itself quickly.
Asymptomatic people did not have systemic interferon reactions and rarely had infected cells.
Unsurprisingly, “infected cells were almost exclusively found” in the nasal cavities of symptomatic people, the authors wrote. The cells lining participants’ nasal cavities start producing SARS-CoV-2 virus, contributing to increased viral load.
“We now have a much greater understanding of the full range of immune responses, which could provide a basis for developing potential treatments and vaccines that mimic these natural protective responses,” said Dr. Nikolić.
RE: I had a Covid infecton once, and never had any symptoms.
If you had no symptoms, how did you know you had Covid?
Same here.
I would like to see this kind of study done on adverse jab reactions. I suspect some of the same biological processes are involved.
EC
“If you had no symptoms, how did you know you had Covid?”
My doctor wanted to give me a Covid test and I said O.K.
23 and Me? Nope. 23 and You, maybe....
I’ll amend the part about masks. They were adopted to the extent that they concealed identity. Walmart wants them to wear masks, cool...slap on a bandana and waltz right past the greeter. Walmart wants them to pay for stuff...not so much. One guy asked me if I thought his new mask made him look like a ninja. It was black, so I said “sure.” I asked him where he got it, and he said he picked it up in the parking lot at 7-11. Nobody got so much as the sniffles, in that bunch.
I had two jabs in 2021 and never got Covid.
My DIL, grandson and granddaughter have been getting jabbed every year - liberal DIL - and none of them got Covid.
I can understand genetically about grandson and granddaughter being like me and never getting it but puzzled about the DIL who is not related and works as school secretary in a public grade school.
No control group. Might you all have remained covid-free without the jab? The world will never know.
True and every year I know people who don’t get the flu and every year I get it 2-4 times and about every 3-4 years I’m in the emergency room because I’m having trouble breathing.
Everyone’s mileage differs
Look up what happened on the “Diamond Princess” for a better view of why you probably didn’t get infected.
Look up what happened on the “Diamond Princess” for a better view of why you probably didn’t get infected.
I think there was good evidence on Vitamin D. They were handing it out in the U.K. 9 out of 10 hospitalized were definicient.
Back in the day Dr. Campbell (I think) reported on a small study that looked at persons who had been exposed to the common-cold coronavirus. That study showed previous infection by the common-cold coronavirus provided long-term 80% relative risk reduction for catching SARS2 coronaviruses. (Far better than the official vaccines)
As far as I know, I haven’t been infected with SARS2 and am not vaxed. Maybe a common cold I had in the past was a coronavirus.
Most of us have been exposed to a corona virus.
To push the vax, they claimed it was ‘novel’ and that would mean all of us would have zero prior immunity. And yet, for the PCR, they used as a testing reference, a ‘related corona virus.’
Dr. Yeadon, former Chief of Science for Pfizer’s allergy and infectious diseases wing, said he knew of a ‘clever’ researcher who contacted survivors of the original SARS outbreak. He tested them with SARS again, and they did not become ill, even after all these years (SARS was Nov 2002).
So he tested the same patients with Covid, and they did not become ill - there was enough similarity between SARS and Covid for the body to fight it off. Makes perfect sense that you wouldn’t have to get sick from every variation of corona virus.
My Indian friend doesn’t get any likenesses. While me, his wife (European) the kids all had covid, he got nothing. I assume it is from growing up in an Indian s hole that super charged his immune system.
Better headline: People who are fast but subtle resist viral infection.
As I said in this thread previously, I now remember that the occassion was a scheduled colonoscopy and the hospital wanted me to get a Covid test. It was positive but I had zero symptons. It delayed the colonoscopy briefly - the wating period and a negative test - and that was all.
Ok. On a side note you can poop in a pot these days and send it off for cancer screening.
HLA-DQA2 is one of many human leukocyte antigen (HLA) genes. HLA genes make proteins displayed on the cell surface. When pathogens infect cells, HLA proteins signal to immune cells that they have been infected.
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