Excess nutrient signals in cells lead to premature aging in animals, study shows

Medical Xpress / The Spanish National Cancer Research Centre / Nature Aging ^ | June 7, 2024 | Alejo Efeyan et al

[ConservativeMind]

Cells are signaled to have nutrients in excess, and this leads to malfunction and inflammation in organs such as the pancreas, the liver and the kidneys. The finding suggests that an intervention on the inflammation alone can relieve symptoms and increase survival.

The research has been conducted on animal models, but comparing their molecular processes with blood samples from people in their 70s indicates that results can be extrapolated to human aging.

…The mTOR protein complex is known to be involved in many processes, as a key agent in multiple functions of the body and especially in metabolism.

The paper finds that when mTOR activity is just slightly increased, aging sets in earlier on, and the lifetime of animals can be shortened by up to 20%.

Given the central role of mTOR in metabolism, this research provides clues to understand why aging-related diseases appear or worsen in people with a high body mass index, an indicator related to obesity and inflammation. It also sheds light on why calorie restriction can promote healthy aging, as certain genes activated by limiting nutrient intake interact with mTOR.

The activity of the mTOR protein complex is regulated according to the amount of nutrients available in the cell.

…The result of this vicious circle is that the lifespan of these animals in which mTOR is working harder than normal is shortened by 20%, which on the human scale would be equivalent to about 16 years.

The study sought to cut this circle by blocking the immune response that causes inflammation. Damage in the organs then improved enough to gain what in humans would be a few years of life.

For this reason, the authors state that acting on chronic inflammation is "a potential therapeutic measure that controls deterioration of health," says Ortega-Molina

[ConservativeMind]

Constantly eating more than needed appears to take off the equivalent of 16 human years of life, due to excess nutrient inflammation across most of our cells.

[ConservativeMind]

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[ConservativeMind]

Somehow addressing the accumulating inflammation can bring back some years of life, however, but reducing the overeating would appear to help quite a bit more.

[ckilmer]

Our bodies are not designed never to be hungry.

[Jonty30]

Killing with kindness?

[BipolarBob]

if they think this going to make me give up my ice cream at night, they have another thing coming.

[BullwinkleMoose]

Intermittent fasting is the easiest way to limit caloric intake, reduce inflammation, and prolong life. I eat during an 8 hour window only and have been doing so for 6 years. I have dropped weight, cured my acid reflux, and even my varicose veins look better. It costs you nothing to try.

[FormerFRLurker]

if they think this going to make me give up my ice cream at night, they have another thing coming.

A man after my own heart!

[Red Badger]

That’s why you live longer by not eating too much...................