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Study sheds light on diabetes drug for prostate cancer (Metformin could help up to 60% of new cases)
Medical Xpress / Columbia University Irving Medical Center / European Urology ^ | Nov. 6, 2023 | Alexandros Papachristodoulou et al

Posted on 11/09/2023 10:04:27 PM PST by ConservativeMind

A study suggests metformin is a drug that could prevent the progression of prostate cancer, but only for tumors with low levels of NKX3.1, which are more likely to develop into aggressive cancers.

The researchers found metformin restores cancer-fighting mitochondrial activity that is lost when NKX3.1 levels are low, prevents prostate cancer progression in mice, and is associated with better survival in patients with low-NKX3.1 tumors but not high-NKX3.1 tumors.

Papachristodoulou found that when prostate cells are under oxidative stress (as happens during prostate cancer development), NKX3.1 moves into the cells' mitochrondria to reduce stress and protect the cells. If NKX3.1 levels are low, less protection is available, and prostate cells are more likely to turn malignant.

The researchers gave metformin to low-NKX3.1 mice that tend to develop prostate cancer.

Papachristodoulou says, "With metformin, we were able to stop further progression of the cancer."

The researchers then looked at human prostate cancer cells and tissues, confirming that metformin works on the same mitochondrial processes in people and prevents further cancerous changes.

Finally, the researchers retrospectively examined the effect of metformin in two groups of men who had been treated for prostate cancer. (Many men in both groups took metformin for their diabetes.)

After measuring NKX3.1 levels in tissue samples from the patients, researchers found that metformin only benefited patients with low NKX3.1 levels and mitochondrial impairment. Remarkably, among men with low NKX3.1 cancers under active surveillance, those taking metformin (three out of three) had their cancers downgraded during the surveillance period, while three out of four patients who did not take metformin had their cancers upgraded.

NKX3.1 levels are not typically measured in men newly diagnosed with prostate cancer, but based on the two cohorts examined, about 50% to 60% of patients may have low-expressing NKX3.1 tumors.

(Excerpt) Read more at ...

TOPICS: Health/Medicine
KEYWORDS: cancer; metformin; prostate; prostatecancer; treatment
The NKX3.1 test can be ordered by your doctor. Metformin, unfortunately, is easy to get, if you are already on track toward diabetes.

It looks like we men have over a 50% chance of having our prostate cancer be partly treatable with metformin.

Although the tests worked with mice and human tissues, the kicker was the human use, as stated in the last two paragraphs, above.

1 posted on 11/09/2023 10:04:27 PM PST by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 11/09/2023 10:04:52 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Didn’t they take a brand of Metformin off the market because it contained carcinogenic particles? My sister-in-law has been on it for years, and she’s always suffered from stomach cramps and diarrhea with it. It’s one of the known side-effects. I was on it briefly many years ago, and had the same problem But hey, if it can help you with prostate cancer, you can forget about the long list of side effects, right?

3 posted on 11/09/2023 10:25:21 PM PST by mass55th (“Courage is being scared to death, but saddling up anyway.” ― John Wayne)
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The inexpensive magical Metformin strikes again!

So when will it suffer the political fate of hydroxychloroquine?

4 posted on 11/09/2023 10:26:12 PM PST by Gene Eric (Don't be a statist!)
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To: mass55th

Yeah, I believe it’s known for those side-effects.

Metformin seems to work for my genetic lineage. But the dosage has been minimal. The dietary approach is best if possible.

5 posted on 11/09/2023 10:34:18 PM PST by Gene Eric (Don't be a statist!)
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To: ConservativeMind

I wonder if any tests have ever been conducted with Berberine which has very similar effects as Metformin but has less undesirable side effects.

6 posted on 11/09/2023 10:38:57 PM PST by Saintgermain
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To: ConservativeMind

Great info, thanks for posting.

I read your posts more than I do the journals now :-)

7 posted on 11/09/2023 10:41:17 PM PST by Bobalu (I can’t even feign surprise anymore.)
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To: mass55th

There was one brand of metformin that was removed from the market a number of years ago. The issue resolved with a few months.

8 posted on 11/09/2023 11:16:48 PM PST by WASCWatch ( WASC)
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To: ConservativeMind

This has been known for at least a decade.

9 posted on 11/09/2023 11:18:11 PM PST by WASCWatch ( WASC)
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To: ConservativeMind

I used to take Metformin for my diabetes. Horrible stuff. Gave me acid reflux that tasted like industrial floor cleaner. Happy was the day that I could go on injections and quit taking it.

10 posted on 11/09/2023 11:48:11 PM PST by Chad C. Mulligan
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To: ConservativeMind

Metformin is a good drug, but a combination of IP6 and curcumin is likely even better.

11 posted on 11/10/2023 4:01:29 AM PST by devere
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To: devere

What’s IP6?

12 posted on 11/10/2023 4:42:31 AM PST by Pearls Before Swine
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To: Pearls Before Swine

13 posted on 11/10/2023 5:32:16 AM PST by devere
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To: ConservativeMind

The public needs to get this through their thick skulls. Cancer is NOT a genetic disease. It is a disease of cellular energy. Metformin proves it.

Change what you do and how you live.

14 posted on 11/10/2023 6:30:54 AM PST by nagant
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To: devere; Bobalu; nagant; Tilted Irish Kilt; Qiviut; metmom; SunkenCiv

I have looked at and read a fair bit of the three links at comment #13. One of the articles referred to how ip-6 increases the rate of natural cell death (apoptosis) in cancerous tissues. A year ago I read that Astaxanthin increased the rate of apoptosis in cancer tissues, but slowed it down in normal tissues. Along with other more common nutrients, I had my partner with prostate cancer and my brother with metastatic liver cancer add this to their daily supplements. My partner’s prostate cancer seems completely gone with a PSA score of 0.001. My brother’s liver metastases areas were shrinking and the doctor was talking about going in an removing some of them. Then he took his fourth Covid booster and his cancer immediately got much worse. He had also run out of Astaxanthin. He now has progressed through two increasingly severe chemo, and is feeling miserable all the time. I recently sent him a renewal of his missing supplements, and hope to see some improvement. I will also be sending him prints of some of this ip-6 material to show his oncologist.

15 posted on 11/11/2023 1:22:53 AM PST by gleeaikin ( Question authority!)
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To: Saintgermain


16 posted on 11/11/2023 4:47:42 PM PST by mbj
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To: gleeaikin

What in your experience is the dose of astaxanthin that is effective against cancer?

17 posted on 11/11/2023 5:38:15 PM PST by devere
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