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Scientists reveal mechanistic link between zinc levels and diabetes (Zinc helps fatty liver and diabetes)
Medical Xpress / eLife ^ | Sept. 25, 2023 | Shek Man Chim et al

Posted on 10/01/2023 11:20:16 AM PDT by ConservativeMind

Researchers have identified a mechanistic link between zinc levels in humans and the risk of type 2 diabetes and fatty liver disease.

Converging lines of evidence have shown that zinc plays a crucial role in insulin production and glucose metabolism. "We know that increasing zinc intake improves blood glucose control in people with prediabetes or type 2 diabetes, and people with a mutation in a key zinc transporter protein have reduced risk of diabetes." says Shek Man Chim.

Chim and colleagues identified a mutation called SLC39A5, associated with increased circulating zinc levels.

The team explored its function by genetically engineering mice lacking the zinc transporter protein. As anticipated, these mice had elevated blood and tissue levels of zinc. When the team fed mice a high-fat, high-fructose diet to induce obesity, there was a significant reduction in fasting glucose compared to the control mice fed the same diet. Similar results were observed in a congenital (leptin receptor-deficiency) model of obesity. Loss of SLC39A5 also resulted in reduced insulin resistance—a hallmark of diabetes where tissues fail to respond to insulin signals trying to trigger glucose uptake from the blood.

Given that diabetes often coincides with non-alcoholic fatty liver disease, the team explored whether loss of SLC39A5 protects the liver, too. As hoped, mice lacking SLC39A5 had less build-up of fat in the liver and in blood markers of liver damage. Moreover, mice lacking SLC39A5 but fed a high-fat, high-fructose diet also had less fat accumulation in the liver and improved insulin sensitivity compared to control mice.

The mice lacking SLC39A5 had reduced liver damage markers, fasting blood glucose and improvements in liver inflammation and fibrosis.

"Our observations suggest that blocking SLC39A5 could be a potential therapeutic avenue for type 2 diabetes and other indications where zinc supplementation alone is inadequate."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: diabetes; fattyliver; zinc
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Higher safe levels of zinc help prevent blood glucose and insulin issues, along with liver inflammation and fibrosis.
1 posted on 10/01/2023 11:20:16 AM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 10/01/2023 11:20:44 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Good for the prostate too.


3 posted on 10/01/2023 11:21:57 AM PDT by Secret Agent Man (Gone Galt; not averse to Going Bronson.)
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To: ConservativeMind

At least 60 minerals/trace minerals are used in the human body to creat health.

Unfortunately, most are not researched well at all.

We do know a lot about flying drones on Mars…


4 posted on 10/01/2023 11:26:54 AM PDT by aMorePerfectUnion (Fraud vitiates everything)
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To: ConservativeMind

Time to buy galvanized cookware and tableware!


5 posted on 10/01/2023 12:06:14 PM PDT by cymbeline
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To: ConservativeMind

.


6 posted on 10/01/2023 12:16:28 PM PDT by sauropod (I will stand for truth even if I stand alone.)
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To: ConservativeMind

Ivermectin also treats fatty liver disease and some types of diabetes.

https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=2825&context=dissertations_2

https://www.sciencedirect.com/science/article/pii/S1471492217300624


7 posted on 10/01/2023 12:22:07 PM PDT by Non-Compliant_Deplorable
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To: ConservativeMind

I had to quit taking Zinc. Made me nauseated.


8 posted on 10/01/2023 12:57:52 PM PDT by MachIV
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To: aMorePerfectUnion
Hyland’s Bioplasma. The 12 most important minerals in easy-to-take formulary. 3-4 times a day dissolved under the tongue until relief, then 1-2x a day.


9 posted on 10/01/2023 1:34:19 PM PDT by ponygirl (Stay gold.)
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To: ponygirl

And Intermittent Fasting (IF). People really need to look into that for fatty liver. We do NOT need to be eating as often as we are.


10 posted on 10/01/2023 1:42:37 PM PDT by ponygirl (Stay gold.)
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To: ConservativeMind

Bkmk


11 posted on 10/01/2023 1:45:10 PM PDT by ptsal (Vote R.E.D. >>>Remove Every Democrat ***)
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To: ConservativeMind

Bkmk


12 posted on 10/01/2023 3:57:09 PM PDT by dennisw (Never attribute to incompetence & stupidity, that which is adequately explained by malice)
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To: Secret Agent Man

Following


13 posted on 10/01/2023 6:40:10 PM PDT by COSIllinois
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To: ponygirl

Yes, so true! My liver enzyme ALT was elevated (67 or higher) for years on a low carb diet, but with frequent snacking throughout the day. I stopped the snacking and now eat only 2 meals a day (11am and 5pm so an 18 hour IF) and my liver enzymes are back to where they should be.


14 posted on 10/01/2023 7:12:54 PM PDT by jmmec2014
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To: ConservativeMind

bump for later reference


15 posted on 10/02/2023 10:56:16 AM PDT by Robert357
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To: Non-Compliant_Deplorable

is there a quality online site for Ivermectin tablets? I prefer those over the paste


16 posted on 10/02/2023 2:43:35 PM PDT by spacejunkie2001
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To: spacejunkie2001

Here’s a link to a list of reliable sources for pill form IVM, HCQ, and most other generic meds that’s posted regularly on Patriots.win. It’s a compilation of places recommended by anons over there.

I’ve done test order from all of them, except the two places in the US, and everything came through just fine, in factory packaging, etc. Since those orders, I’ve opted to use ReynoldMeds because he has such great customer service (email) and he loves America and President Trump. (I get not just IVM from him, but all my regular meds and my stash of various antibiotics.)

PLACES TO BUY IVERMECTIN / HCQ, ANTIBIOTICS, ALL REGULAR MEDS (SOME SHIP TO UK, AUS, CANADA) — Link to Protocols for Use/Dose inside

https://patriots.win/p/17r9Rj8cNU/places-to-buy-ivermectin—hcq-an/


17 posted on 10/02/2023 3:20:35 PM PDT by Non-Compliant_Deplorable
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To: Non-Compliant_Deplorable

awesome, thank you. I’ll opt for ReynoldsMeds as well :)


18 posted on 10/02/2023 4:08:28 PM PDT by spacejunkie2001
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To: spacejunkie2001

If you correspond with him by email, tell him you found his info on Patriots.win. (He reads there regularly — and here, as well, I think.)


19 posted on 10/02/2023 4:40:03 PM PDT by Non-Compliant_Deplorable
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To: Non-Compliant_Deplorable

will do


20 posted on 10/02/2023 4:41:04 PM PDT by spacejunkie2001
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