Scientists reveal mechanistic link between zinc levels and diabetes (Zinc helps fatty liver and diabetes)

Medical Xpress / eLife ^ | Sept. 25, 2023 | Shek Man Chim et al

[ConservativeMind]

Researchers have identified a mechanistic link between zinc levels in humans and the risk of type 2 diabetes and fatty liver disease.

Converging lines of evidence have shown that zinc plays a crucial role in insulin production and glucose metabolism. "We know that increasing zinc intake improves blood glucose control in people with prediabetes or type 2 diabetes, and people with a mutation in a key zinc transporter protein have reduced risk of diabetes." says Shek Man Chim.

Chim and colleagues identified a mutation called SLC39A5, associated with increased circulating zinc levels.

The team explored its function by genetically engineering mice lacking the zinc transporter protein. As anticipated, these mice had elevated blood and tissue levels of zinc. When the team fed mice a high-fat, high-fructose diet to induce obesity, there was a significant reduction in fasting glucose compared to the control mice fed the same diet. Similar results were observed in a congenital (leptin receptor-deficiency) model of obesity. Loss of SLC39A5 also resulted in reduced insulin resistance—a hallmark of diabetes where tissues fail to respond to insulin signals trying to trigger glucose uptake from the blood.

Given that diabetes often coincides with non-alcoholic fatty liver disease, the team explored whether loss of SLC39A5 protects the liver, too. As hoped, mice lacking SLC39A5 had less build-up of fat in the liver and in blood markers of liver damage. Moreover, mice lacking SLC39A5 but fed a high-fat, high-fructose diet also had less fat accumulation in the liver and improved insulin sensitivity compared to control mice.

The mice lacking SLC39A5 had reduced liver damage markers, fasting blood glucose and improvements in liver inflammation and fibrosis.

"Our observations suggest that blocking SLC39A5 could be a potential therapeutic avenue for type 2 diabetes and other indications where zinc supplementation alone is inadequate."

[ConservativeMind]

Higher safe levels of zinc help prevent blood glucose and insulin issues, along with liver inflammation and fibrosis.

[ConservativeMind]

The “Take Charge Of Your Health” Ping List
This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

[Secret Agent Man]

Good for the prostate too.

[aMorePerfectUnion]

At least 60 minerals/trace minerals are used in the human body to creat health.

Unfortunately, most are not researched well at all.

We do know a lot about flying drones on Mars…

[cymbeline]

Time to buy galvanized cookware and tableware!

[sauropod]

.

[Non-Compliant_Deplorable]

Ivermectin also treats fatty liver disease and some types of diabetes.

https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=2825&context=dissertations_2

https://www.sciencedirect.com/science/article/pii/S1471492217300624

[MachIV]

I had to quit taking Zinc. Made me nauseated.

[ponygirl]

Hyland’s Bioplasma. The 12 most important minerals in easy-to-take formulary. 3-4 times a day dissolved under the tongue until relief, then 1-2x a day.

[ponygirl]

And Intermittent Fasting (IF). People really need to look into that for fatty liver. We do NOT need to be eating as often as we are.

[ptsal]

Bkmk

[dennisw]

Bkmk

[COSIllinois]

Following

[jmmec2014]

Yes, so true! My liver enzyme ALT was elevated (67 or higher) for years on a low carb diet, but with frequent snacking throughout the day. I stopped the snacking and now eat only 2 meals a day (11am and 5pm so an 18 hour IF) and my liver enzymes are back to where they should be.

[Robert357]

bump for later reference

[spacejunkie2001]

is there a quality online site for Ivermectin tablets? I prefer those over the paste

[Non-Compliant_Deplorable]

Here’s a link to a list of reliable sources for pill form IVM, HCQ, and most other generic meds that’s posted regularly on Patriots.win. It’s a compilation of places recommended by anons over there.

I’ve done test order from all of them, except the two places in the US, and everything came through just fine, in factory packaging, etc. Since those orders, I’ve opted to use ReynoldMeds because he has such great customer service (email) and he loves America and President Trump. (I get not just IVM from him, but all my regular meds and my stash of various antibiotics.)

PLACES TO BUY IVERMECTIN / HCQ, ANTIBIOTICS, ALL REGULAR MEDS (SOME SHIP TO UK, AUS, CANADA) — Link to Protocols for Use/Dose inside

https://patriots.win/p/17r9Rj8cNU/places-to-buy-ivermectin—hcq-an/

[spacejunkie2001]

awesome, thank you. I’ll opt for ReynoldsMeds as well :)

[Non-Compliant_Deplorable]

If you correspond with him by email, tell him you found his info on Patriots.win. (He reads there regularly — and here, as well, I think.)

[spacejunkie2001]

will do