Posted on 02/06/2023 3:38:31 PM PST by ConservativeMind
Rejuvenating an older person's blood may now be within reach, based on recent findings.
An anti-inflammatory drug, already approved for use in rheumatoid arthritis, can turn back time in mice and reverse some of the effects of age on the hematopoietic system.
"These results indicate that such strategies hold promise for maintaining healthier blood production in the elderly," Mitchell says.
The researchers only identified the drug after a comprehensive investigation of the stem cells that create all blood cells and the niches where they reside in the center of the bones.
Mitchell took a closer look at the stem cells' environment, the bone marrow. "Blood stem cells live in a niche; we thought what happens in this specialized local environment could be a big part of the problem," Mitchell says.
With techniques developed in the lab that enable detailed investigation of the bone marrow milieu, the researchers found that the aging niche is deteriorating and overwhelmed with inflammation, leading to dysfunction in the blood stem cells.
One inflammatory signal released from the damaged bone marrow niche, IL-1B, was critical in driving these aging features, and blocking it with the drug anakinra remarkably returned the blood stem cells to a younger, healthier state.
Even more youthful effects on both the niche and the blood system occurred when IL-1B was prevented from exerting its inflammatory effects throughout the animal's life.
The researchers are now trying to learn if the same processes are active in humans and if rejuvenating the stem cell niche earlier in life, in middle age, would be a more effective strategy.
Meanwhile, "treating elderly patients with anti-inflammatory drugs blocking IL-1B function should help with maintaining healthier blood production."
(Excerpt) Read more at medicalxpress.com ...
In the write up, they mention anakinra, also known as Kineret.
bkmk
I’m still holding out and waiting for a full body transplant.
The other issue is that you could be walking around with genetic defects in your IL1B gene that make you susceptible to things like Antisynthetase system.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732678/
Tinkering around with the IL1b gene might trigger something bad...or it might be possible that it would help. Anyone that has one of the components of Antisynthetase might check what their Dr has to say
Any anti-inflammatory drug is suppressing the immune system to some extent.
there was a previous thread about glutamate.
https://selfhack.com/blog/interleukin-1/
“Evidence suggests that IL-1 can potentiate or inhibit the effects of glutamate. IL-1b causes “synaptic hyperexcitability” and neuronal degeneration [40]. This isn’t conducive to stable thinking.”
Currently it looks like this stuff is expensive and not well understood. But useful in extreme situations.
But it does show promise that researchers are improving their understanding of the way stem cells work.
for people who have autoimmune issues that involve Il1b or want to deal with IL1b issues doxycycline may work.
https://selfhack.com/blog/interleukin-1/
Doxy did help me but I have been afraid to try it long term for fear of developing immunity etc.
I’ll turn 70 next week. I’ve been giving blood regularly for the last half year on the theory that, I’ll completely change out my blood in another year or so. That the new blood my body generates will improve my health. That this is a cheap way to do what the super rich do in buying young blood for transfusions.
Granted new blood generated by my body is not as good as young blood but I’ve been taking plenty of NAC, glycine and and B3 variations—plus a bunch of other supplements—to push up various blood markers to more youthful levels.
My question is —do either of you know enough on the subject to say as to whether the new blood my body generates after giving blood—has some longevity benefits?
I dont know anything about this topic other than this...I have seen info about donating plasma to help regenerate blood and also deal with issues such as too much iron.
I started looking into it but I dont qualify because I have a faulty bone marrow that affects my RBCs.
In theory, I can see why it might be beneficial to do it.
You can get a very similar effect without drugs.
Have a pint taken out every couple months.
Forces your body to produce new blood. Much smoother flowing and viscous.
Plus you don’t have to worry about any number of possible transfusion problems.
Yes but not the same thing as shutting down a regulatory element.
“There are some natural compounds that partly block Il-1B.”
like what? What foods have it?
I will be 72 this week and have been donating blood for seven or eight years. Twice a year. Not sure what the health benefits are, but it makes sense that if you are exercising the blood-creating aspect of your body that it would be beneficial. I have discontinued it temporarily until they stop requiring the useless masks.
I will be 72 this week and have been donating blood for seven or eight years. Twice a year. Not sure what the health benefits are, but it makes sense that if you are exercising the blood-creating aspect of your body that it would be beneficial. I have discontinued it temporarily until they stop requiring the useless masks.
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