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Peer-Reviewed Study Confirms Fatal Flaw in PCR Testing: 42% False Discovery Rate for SARS-CoV-2 nonQ-RT-PCR Test. This means COVID-19 Vaccine Outcomes Rate Data are Unreliable and Invalid
substack.com ^ | October 31, 2022 | James Lyons-Weiler

Posted on 11/02/2022 1:38:27 PM PDT by ransomnote

[H/T countRECOUNT]

All COVID-19 Vaccine Studies Used nonQ-RT-PCR to determine case status. All of the estimates of outcome are unreliable. This is the most important study we will ever likely publish in our journal.

NB: The toy math example to show how calculations of False Discovery Rate lead to bias in favor of false positives, an error has been corrected. Corrections and changes are in bold. The original article references to ‘false positive rate’ will also be updated to ‘false discovery rate’. We thank our readers for catching those errors!

We have just published a new study that shows that nonQ-RT-PCR (non-quantitative RT-PCR testing as used to diagnose COVID-19 from 2020 to the present day suffers a flaw that ultimately draws into question all of what has been reported on COVID-19 by official channels, including the results of COVID-19.

Specifically, assuming a 5% prevalence rate, the high false discovery rate (42%) of the use of nonQ-RT-PCR means

1. For every 50 true positives out of 1,000, a total of 86 people with or without SARS-CoV-2 infection or residual fragments will be reported. Of these, 36 of these will be false positives.

2. For every 50 true positives, 86 people without SARS-CoV-2 infection or residual fragments will be have to be isolated/quarantined. Of these, 36 will not be infected.

3. For every 50 true positives that are tested and found positive in-hospital, 86 people with or without SARS-CoV-2 infection or residual fragments will be told that they "have COVID-19". If the 36 false positive patients are hospitalized with other COVID-19 patients, they will likely then contract a SARS-CoV-2 infection.

4. The number of "cases" via positive PCR has been overstated by a factor of 72% (the original post read “80:1” assuming a prevalence of 5%).

5. This is true for generic case reporting up until May 2021 when CDC decided to reduce the PCR cycle threshold value (Ct) for the vaccinated to less than 27, leaving the unvaccinated rate biased by high false discovery rate of arbitrarily high Ct, biasing all reported rates in these two groups favoring cases in the unvaccinated from that point on.

6. This +72% bias is true in any clinical trial or any study that used arbitrarily high Ct values, INCLUDING THE VACCINE STUDIES.

As a direct result of this fatal flaw, combined with CDC’s gaff “PCR+ = COVID-19"?

There are no credible COVID-19 vaccine trial data.

In 2003, CDC took the credit for curtailing the SARS-CoV-1 transmission. Among the method of control they claimed were essential to this included SARS-CoV-1 strain-specific PCR primers used to produce amplicons that were sequenced. The presence of the sequence was used to infer, correctly, whether the PCR reaction had produced a population of SARS-CoV-1 DNA molecules that were sequenced using FDA-designated gold standard - Sanger Sequencing, or an arbitrary population of DNA molecules that represented off-target amplicons.

In 2020, for reasons no one has ever explained, the CDC changed the nucleic acid detection protocol to one that had never been tried before for control of respiratory viruses. Instead of using sequence-based detection, they merely used the results of a non-quantitative reverse transcriptase (RT)-PCR as evidence of the presence of the virus, and then, equally inexplicably, decided to determine that a positive nonQ-RT-PCR test result indicated disease (COVID-19).

Anyone trained in nucleic assays would know this would lead to excessive false positives. Somehow, per official narrative, zero false positive test results were expected by CDC - even with their own test, which had an arbitrarily high Ct cutoff of 40.

MORE AT LINK: https://popularrationalism.substack.com/p/peer-reviewed-study-confirms-fatal

 



TOPICS: Conspiracy; Health/Medicine; Miscellaneous; Science
KEYWORDS: clotshot; covidobsession; deathjab; dumbingdownfr; falsepositive; garbagesource; pleasegethelp; spamsomnote; substacktrash; vaccines
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1 posted on 11/02/2022 1:38:27 PM PDT by ransomnote
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To: SecAmndmt; datura; Fractal Trader; bagster; grey_whiskers; metmom; Jane Long; tatown; ...

PING


2 posted on 11/02/2022 1:39:38 PM PDT by ransomnote (IN GOD WE TRUST)
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To: ransomnote

File this one under N for No ——.
We knew that when they started using PCR testing. Even the inventor said they were not capable of detecting Covid accurately.
My wife is a Nurse and she was telling me how they were told to raise the sensitivity on the machines because Covid was ‘hiding’ from the tests. WTF?


3 posted on 11/02/2022 1:44:21 PM PDT by Semper Vigilantis (I refuse to grow up and you can't make me!)
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To: ransomnote

Wow. un effing believable.


4 posted on 11/02/2022 1:45:23 PM PDT by yldstrk (Bingo! We have a winner!)
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To: ransomnote

The published efficacy of SARS-CoV-2 vaccines, the published breakthrough rate, the published re-infection rate estimates - all of it is potentially rubbish given the 42% false discovery rate. No credible data exist on the efficacy or real-world effectiveness of SAR-CoV-2 targeting vaccines.


5 posted on 11/02/2022 1:47:11 PM PDT by mjp (pro-freedom & pro-wealth $)
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To: ransomnote; gas_dr

For your reading pleasure!


6 posted on 11/02/2022 1:48:06 PM PDT by SoConPubbie (Mitt and Obama: They're the same poison, just a different potency)
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To: ransomnote

The false positives were obvious when those testing positive had no symptoms. The false positives kept the fear going and were used to discredit the vaccine.


7 posted on 11/02/2022 1:48:27 PM PDT by Socon-Econ (adi)
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To: ransomnote

“This is the most important study we will ever likely publish in our journal.”

and

“We have just published a new study that shows that nonQ-RT-PCR (non-quantitative RT-PCR testing as used to diagnose COVID-19 from 2020 to the present day suffers a flaw that ultimately draws into question all of what has been reported on COVID-19 by official channels, including the results of COVID-19.”

Who is we?

Sub stack does not publish scientific articles.

Why are all the sub stack articles so poorly written and presented?

— Note. The vaccines do not work - I am only addressing the incomprehensible poor quality article, too representative of what is often posted here.


8 posted on 11/02/2022 1:50:47 PM PDT by ifinnegan (Democrats kill babies and harvest their organs to sell)
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To: Semper Vigilantis

The number of cycles needed to detect the virus depends on who is President. If it’s President Trump you have to run more cycles.

It’s science.

Sarcasm


9 posted on 11/02/2022 1:52:47 PM PDT by packagingguy
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To: Socon-Econ

>>The false positives kept the fear going and were used to discredit the vaccine<<

Expect THIS to be used against Trump...


10 posted on 11/02/2022 1:53:04 PM PDT by Does so (It's not our guns...It's your SONS!)
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To: Semper Vigilantis

The inventor said to only cycle the test 25 times or you will pick up other viruses.

CDC said 35 times (94% false positives)

We went from 36 million case of influenza in 2019 to 7000 in 2020. Masks really work! /s


11 posted on 11/02/2022 1:53:58 PM PDT by lizma2
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To: ransomnote

The new CDC director spoke to PCR tests flagging false positives 12 weeks after you weren’t officially infected.

This seemingly led to the CDC finally banning the use of the “Gold Standard” test doctors, governments, and businesses were requiring.

I personally believe the false positives were far higher if a fake positive happens after 12 weeks of non-infection.


12 posted on 11/02/2022 1:54:36 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Socon-Econ
These were never used in such a context. The vaccine was always “great to have/mandate.”

I assume you think anti-COVID vaccine people wielded undue authority over the Fauci’s of the world, and that governors like DeSantis smeared the vaccine and a mandate for it, using PCR false positives?

Get real.

13 posted on 11/02/2022 1:59:20 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: lizma2

Didn’t the inventor die? Under mysterious circumstances?


14 posted on 11/02/2022 2:00:26 PM PDT by Jane Long (What we were told was a “conspiracy theory” in 2020 is now fact. 🙏🏻 Ps 33:12)
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To: Semper Vigilantis

“the inventor said they were not capable of detecting Covid accurately.” True. Christian Drosten and his colleagues had published an article in Eurosurveillance on January 23, 2020, in which they claimed to have developed a RT-PCR test for SARS covid 19. But Christian Drosten and his colleagues did not have the SARS covid 19 virus while making the RT-PCR test. Doh! It’s like not having oatmeal while making oatmeal cookies.


15 posted on 11/02/2022 2:02:23 PM PDT by Falconspeed ("Keep your fears to yourself, but share your courage with others." Robert Louis Stevenson.)
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To: ransomnote

it allowed fedgov to control the number of cases and therefore hospitalizations and deaths

fauci and wallensky said hospitalizations included with and from covid and would investigate

still waiting


16 posted on 11/02/2022 2:02:45 PM PDT by joshua c (to disrupt the system, we must disrupt our lives, cut the cable tv)
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To: ransomnote

Quite the verbiage- so it’s the test’s flaw that made it fatal then, not collaborating and colluding with evil by men? We need test control! And I thought the test was just a delivery system.


17 posted on 11/02/2022 2:07:18 PM PDT by pops88 ( Helping usher the glory of God into Las Vegas)
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To: Jane Long

He died but I thought it was from pneumonia.


18 posted on 11/02/2022 2:08:26 PM PDT by lizma2
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To: ifinnegan
In the General/Chat forum, on a thread titled Peer-Reviewed Study Confirms Fatal Flaw in PCR Testing: 42% False Discovery Rate for SARS-CoV-2 nonQ-RT-PCR Test. This means COVID-19 Vaccine Outcomes Rate Data are Unreliable and Invalid, ifinnegan wrote:

“This is the most important study we will ever likely publish in our journal.”

and

“We have just published a new study that shows that nonQ-RT-PCR (non-quantitative RT-PCR testing as used to diagnose COVID-19 from 2020 to the present day suffers a flaw that ultimately draws into question all of what has been reported on COVID-19 by official channels, including the results of COVID-19.”

Who is we?

Sub stack does not publish scientific articles.

Why are all the sub stack articles so poorly written and presented?

— Note. The vaccines do not work - I am only addressing the incomprehensible poor quality article, too representative of what is often posted here.

 

"We" is the author of this substack piece and a colleague. If you read the article, he wrote about their work and linked to publications and a presentation. But you have to read it to know that.

I'm grateful for substack - it allows scientists to publish results of their research in order to reach the general public who lack subscriptions to scientific journals. So many more would be dead from the Plandemic and the 'not-a-vaccine' if not for researchers getting past the public censorship with websites like substack.


19 posted on 11/02/2022 2:16:22 PM PDT by ransomnote (IN GOD WE TRUST)
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To: lizma2

He was an open critic of FRAUDci....

https://freerepublic.com/focus/search?m=all;o=time;q=quick;s=pcr%20inventor

The Mysterious Death of Dr. Fauci’s Most Notable Critic
banned.video ^ | May 21 | banned.video

Posted on 5/22/2021, 2:56:07 PM by RandFan

The late Dr. Kary Mullis, the inventor of the PCR test, has been blowing the whistle on Fauci and big pharma for thirty years...

https://freerepublic.com/focus/f-chat/3961529/posts

🤷‍♀️

(See tagline.)


20 posted on 11/02/2022 2:22:16 PM PDT by Jane Long (What we were told was a “conspiracy theory” in 2020 is now fact. 🙏🏻 Ps 33:12)
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