Posted on 10/24/2022 1:59:21 PM PDT by ConservativeMind
Pancreatitis is inflammation of the pancreas often associated with long-term alcohol consumption. Recurrent attacks of acute pancreatitis results in chronic pancreatitis, causing weight loss, pain, diabetes, and even pancreatic cancer.
Excessive alcohol consumption is associated with 40–70% of pancreatitis cases.
With repeated episodes of binge drinking the pancreas eventually builds up scar tissues with persistent inflammation, weakening its endocrine and exocrine functions needed to digest food and regulate blood sugar levels. This chronic insult to the organ can cause excruciating pain, malnutrition, diabetes, and death.
Accumulating scientific evidence suggests that continued alcohol consumption with established alcoholic pancreatitis instigates irreversible pancreatic damage due to recurrent episodes of acute pancreatitis by fostering a continuous fibro-inflammatory microenvironment within the pancreas.
"Using an established alcoholic pancreatitis mice model, we have addressed two of the major unanswered questions with regards to the pathogenesis of pancreatitis. We've characterized the pancreas-specific signaling pathways in this process and determined if utilizing novel therapeutic agents can attenuate the severity of alcoholic pancreatitis progression, despite continued alcohol triggers" said Siddharth Mehra, Ph.D.
The microbiome has been implicated in gastrointestinal inflammation as a critical mediator of overall gut health. Urolithin A is a natural compound synthesized by gut bacteria from ingested ellagitannins, a class of hydrolyzable tannins found mainly in pomegranate, berries, and nuts. Previous work from the group has shown that Urolithin A is a potent anti-inflammatory agent in several pre-clinical disease models and exhibits anti-tumor activity in gastrointestinal cancers.
"Our studies have demonstrated that Urolithin A is well tolerated and does not elicit any adverse toxic effects at clinically relevant doses in mice," says Dr. Nagathihalli. The FDA recognizes Urolithin A as a "safe dietary supplement."
"We have shown that Urolithin A can help improve the effectiveness of treating alcoholic pancreatitis despite continued alcohol intake," said Dr. Mehra.
(Excerpt) Read more at medicalxpress.com ...
Thirty three years off that poison tomorrow. God is good.
unprovable....most DUI's are tested for alcohol, because its easy to test for....I suspect that for several decades now we've had alcohol taking full blame for accidents when the driver was impaired with cocaine,meth,weed, opiates, etc...
"There is NO benefit, either personally or societally, from drinking alcohol."
and yet Jesus made water into wine.....
I rarely drink but why the heck not?....its a relaxant.....its used for pain control in many countries...in Russia they use vodka to treat dystonia for example.
what perplexes me about this study is why prevention is not pushed and instead researching a drug that gives the green light to drinkers to keep drinking....
pancreatitis is avoidable if people stop drinking....although after you've had a couple rounds of pancreatitis drinking or not you are more likely to have further episodes....
"Wine" is the juice from the grape. It is wholly likely, and I believe it is the case, the Jesus made "New" wine from water, non-alcoholic. After all, the practice was mentioned that the host of a wedding party would serve the most intoxicating wine FIRST, and then the non-intoxicating wine afterwards after the guests were inebriated and were less likely to tell the difference. That's why the hosts were astonished that the "best" wine was brought out at the end of the feast.
Yes. Including myself. It’s paid off. It just took some time.👍
They can have my Wild Turkey 101 when they pry it from my cold dead hands.
Almost zero people stop on their first try.
Well. Let’s not get carried away.😉
Some people handle alcohol just fine. Others don’t.
No evidence this wine was alcoholic. It was literally juice of grapes - it could have been fermented or not from the labeling.
No doubt.
Worked for me the first time , but it took some time to gather the courage.😉🍻
That’s great. Some people, unfortunately, take dozens and dozens of times.
and yet Jesus made water into wine.....
No evidence this wine was alcoholic. It was literally juice of grapes - it could have been fermented or not from the labeling.
I heard he didn’t pay taxes on it either.
My Dad passed this Spring from cancer of the Pancreas and he was a heavy drinker. Glad I quit years earlier. Life’s to short. Got things I still wanna do!🙂
I forget the Clint Eastwood movie but the quote has always stuck with me…”Man’s got to know his limitations “.
Literally no one except fundi Baptists and Welches believes the wine was non-alcoholic
Almost zero people stop on their first try.
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I got pancreatitis almost 7 years ago and haven’t had a drop since. I used to drink beer every day. At least a six pack. It caught up to me in my 50’s.The pain I was in was enough for me to stop. I do miss beer though.
50’s is usually when complications arise for those who have had a couple too many.
A guy I know died at 41 from organ failure.
One of the things Noah did after The Flood was to get drunk and pass out naked on his front lawn.
Rednecks been around a Looooooong time.
Bwahahahaha
Nicely played
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