Posted on 09/06/2022 4:00:59 PM PDT by ConservativeMind
A new study suggests that lactate, a metabolic byproduct produced by cells during strenuous exercise, can rejuvenate immune cells that fight cancer. The finding could eventually be used to develop new strategies to augment the anti-tumor effect of cancer immunotherapies.
"The lactate that we usually think of as a waste product appears to have a previously unrecognized role in fighting cancer," said Jinming Gao, Ph.D.
To investigate, Dr. Gao gave lactate injections to mice with colon cancer or melanoma; other tumor-bearing mice received glucose injections. While glucose had little effect, tumor growth was significantly reduced in mice treated with lactate. When the researchers tried the same experiment in mice genetically engineered to lack T cells, this anti-tumor benefit was blocked, suggesting that lactate appeared to be exerting its effects through this immune cell population.
Administering lactate alone didn't completely eliminate the tumors. But when the researchers added a commonly used immune checkpoint inhibitor—a type of cancer immunotherapy that releases the brakes that prevent T cells from fighting malignancies—about half the mice became completely tumor-free. Lactate also significantly improved the effects of a cancer-fighting vaccine and improved the anti-cancer response of cultured T cells that were injected into tumor-bearing mice.
Further single-cell RNA sequencing analysis showed that more T cells infiltrated the tumors of the lactate-treated mice. Compared to animals that didn't receive this treatment, T cells from the mice that received lactate expressed more genes associated with stem-like T cells and a smaller number of genes associated with exhaustion markers, making them more fit to effectively fight cancer.
Dr. Gao said the data suggest that lactate could be used to supplement existing immunotherapies. It also suggests that exercise, which naturally raises lactate levels, may be protective against cancer.
(Excerpt) Read more at medicalxpress.com ...
I am dubious. Many cancers feed on LDH. Don’t know if the ones they studied do. In fact, apparently most frontline Doctors have no clue that an LDH that is not raised can still signal cancer if the isoform composition changes
LDH catalyzes pyruvate to lactate.
Cancer feeds on LDH.
In any event, hopefully they can do something with this.
I know they have studied trying to target LDH to cure cancer
What about milk from cows. Lactate?
btw, can’t remember the exact details but one study that had success with LDHA and cancer saw the body switch the process to LDHB to feed the same cancer.
It’s a malevolent crafty SOB.
Be sure to drink lots of milk.
Every little steps helps...
It did not appear that blood provided lactate helped cancer cells over T-cells.
Lactose, not lactate
So perhaps Cancer uses LDH to provide the lactate as our body used it to create lactate.
Maybe it is siphoning off the ability for the T cells and then Science provides the needed lactate for the T cels.
here is an article on how LDHA and LDHB fit into the cancer story
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539221/
IIRC, LDH-5 is found in liver and muscles of the skeleton but don’t expect Drs know know anything about the LDH-5/LDH-4 flip. They do seem to know about the LDH-1/LDH-2 flip
What you will see over and over again in studies is that when Total LDH AND/OR there is a composition change it can mean cancer. Drs just seem to think if your LDH Total is normal everything is ok.
You might be able to catch cancer sooner if they paid attention to the flips
btw,the only reason I know anything about this is because I have a flipped pattern.
It’s been acknowledged that exercise improves outcomes for cancer patients. This paper is interesting because it proposes a possible mechanism of action.
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