Credit: Unsplash/CC0 Public Domain Posted on 07/11/2022 1:13:08 PM PDT by Red Badger
Credit: Unsplash/CC0 Public Domain
The latest study to examine how tiny amounts of psychedelics can impact mental health provides further evidence of the therapeutic potential of microdosing.
Published in Scientific Reports this week, the study followed 953 people taking regular small amounts of psilocybin and a second group of 180 people who were not microdosing. This research, led by University of British Columbia Okanagan's Dr. Zach Walsh and doctoral student Joseph Rootman, is the latest study to come from the Microdose.me project.
For the 30-day study, participants were asked to complete a number of assessments that tapped into mental health symptomology, mood and measures of cognition. For example, a smartphone finger tap test was integrated into the study to measure psychomotor ability, which can be used as a marker for neurodegenerative disorders including Parkinson's disease.
Those microdosing demonstrated greater improvements in mood, mental health and psychomotor ability over the one-month period, compared to non-microdosing peers who completed the same assessments.
"This is the largest longitudinal study of this kind to date of microdosing psilocybin, and one of the few studies to engage a control group," says Dr. Walsh, who teaches in the Irving K. Barber Faculty of Arts and Social Sciences. "Our findings of improved mood and reduced symptoms of depression, anxiety and stress add to the growing conversation about the therapeutic potential of microdosing."
Large doses of psychedelic psilocybin mushrooms have a long history of use among some Indigenous peoples and are prized in Western culture for their psychedelic effects, explains Dr. Walsh. They were also labeled an illicit substance during the American-led "war on drugs." But recent interest has expanded from large dose psychedelic use—known for creating dramatic alterations in mood and consciousness—to the potential therapeutic application of smaller microdoses; amounts so small they minimally interfere with daily functioning.
The Microdose.me project is conducted by an international team including Dr. Pam Kryskow from UBC Vancouver, Maggie Kiraga and Dr. Kim Kuypers from Maastricht University in the Netherlands, American mycologist Paul Stamets, and Kalin Harvey and Eesmyal Santos-Brault of the Quantified Citizen health research platform.
Microdosing involves regular self-administration in doses small enough to not impair normal cognitive functioning. The doses can be as small as 0.1 to 0.3 grams of dried mushrooms, and may be taken three to five times a week.
The most widely reported substances used for microdosing are psilocybin mushrooms and LSD. Psilocybin mushrooms are considered non-addictive and relatively non-toxic—especially when compared to tobacco, opioids and alcohol.
"Our findings of mood and mental health improvements associated with psilocybin microdosing align with previous studies of psychedelic microdosing, and add to them through the use of a longitudinal study design and large sample that allowed us to examine consistency of effects across age, gender and their mental health," says Rootman.
The comparisons of microdosers to non-microdosers over the one-month period of the study indicated greater improvements among microdosers when asked about their mood, depression, anxiety and stress, he explains. Analyses of the finger tap test showed that microdosers demonstrated a more positive change in performance than non-microdosers, particularly among people over the age of 55.
"Despite the promising nature of these findings, there is a need for further research to more firmly establish the nature of the relationship between microdosing, mood and mental health, and the extent to which these effects are directly attributable to psilocybin rather than participant expectancies about the substance," says Dr. Walsh.
The study was not designed to investigate the potential influence of participant expectancy on microdose outcomes, but the authors note this is a necessary advancement in the field.
"Considering the tremendous health costs and ubiquity of depression and anxiety, as well as the sizable proportion of patients who do not respond to existing treatments, the potential for another approach to addressing these disorders warrants substantial consideration," Rootman says.
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Study finds psychedelic microdosing improves mental health More information: Joseph M. Rootman et al, Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls, Scientific Reports (2022). DOI: 10.1038/s41598-022-14512-3 Journal information: Scientific Reports
I thought that question was put to rest way back in the 60s.
Research is ongoing............... 😜😉😊
Coffee, as in 2-5 cups a day, has much the same effect on mood, and has proven anti-cancer effects as well.
Maybe I’ll try a micro-dose of psilocybin then. Personal possession is not illegal here. No idea where to get it, though, and I’d have to be absolutely positive it is genuine and uncontaminated.
But, it has to be brewed coffee. Instant coffee showed zero anti-cancer effects.
It’s for the science, you know.
My research continued yesterday with a visit to Rock N Brews in The Colony. Naturally, the Texas Flood Margarita caught my eye, and really put me in a good mood. After the second, I gave the car keys to my wife.
Don't know about my mental health, but my mood was greatly improved.
They didn’t do microdosing in the ‘60s. They did trips.
I have no idea either, I would suggest look at a few local health/vegan food stores.
Most of them carry CBD oil which I’ve used in the past and believe it worked for me.
Another “Duh!” study.
Many many people are microdosing or using full dose psilocybin for mood management.
Seems to work well in certain subgroups.
I expect ongoing research to be very positive.
It will be nice to have another option besides spring. Ssnis
The Temptations sang about it in 1970 in
Psychedelic Shack:
....
Psychedelic shack, that’s where it’s at, yeah, oh yeah
There ain’t no such a thing as time
Incense in the air, peace signs painted everywhere
I guarantee you this place will blow your mind
They got a cat there shoutin’ the blues, talkin’ ‘bout payin’ some dues
People walkin’ round reciting poetry, yeah
Screaming guitars and a thousand colored lights
People, I’m telling you this place is really out of sight
The pastures in and around Baton Rouge were loaded with them after a rain. They were legal and were like caffeine to me. No high, though.
Turn off your mind, relax and float downstream,
It is not dying, it is not dying.
You’re excused.
Martin Luther King Boulevard - Chris Rock........................
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