Posted on 06/12/2022 11:08:17 AM PDT by libh8er
Recently, a tiny group of people with rectal cancer saw their disease vanish after experimental treatment.
Now, in another breakthrough, a new compound synthesized by Dr. Jung-Mo Ahn, a University of Texas at Dallas researcher, has been found to kill a broad spectrum of hard-to-treat cancers, including triple-negative breast cancer, leaving healthy cells unscathed.
He exploited a weakness in cells that were hitherto not targeted by the other drugs.
The study, which was carried out in isolated cells, both in human cancer tissue and in human cancers grown in mice, was published in the journal Nature Cancer.
Only a few options for patients with triple-negative breast cancer
Ahn, a co-corresponding author of the study and a UT Dallas associate professor of chemistry and biochemistry in the School of Natural Sciences and Mathematics, has been working on small molecules that target protein-protein interactions in cells for more than a decade. Previously, he had developed potential therapeutic candidate compounds for treatment-resistant breast cancer and prostate cancer.
In his current research, Ahn and his colleagues tested a new compound he synthesized called ERX-41 for its effects on breast cancer cells - those that contained estrogen receptors (ERs) and those that do not.
Now, there are effective treatments for patients with ER-positive breast cancer, but only a few treatment options for patients with triple-negative breast cancer (TNBC) exist. It lacks receptors for estrogen, progesterone, and human epidermal growth factor 2. TNBC is known to affect women under 40 and has worse outcomes than other types of breast cancer.
"The ERX-41 compound did not kill healthy cells, but it wiped out tumor cells regardless of whether the cancer cells had estrogen receptors," Ahn said. "In fact, it killed the triple-negative breast cancer cells better than it killed the ER-positive cells.
"This was puzzling to us at the time. We knew it must be targeting something other than estrogen receptors in the TNBC cells, but we didn't know what that was."
Soon, the researchers discovered that ERX-41 binds to lysosomal acid lipase A (LIPA), a cellular protein. LIPA is found in a cell structure called the endoplasmic reticulum, an organelle that processes and folds proteins.
"For a tumor cell to grow quickly, it has to produce a lot of proteins, and this creates stress on the endoplasmic reticulum," Ahn said. "Cancer cells significantly overproduce LIPA, much more so than healthy cells. By binding to LIPA, ERX-41 jams the protein processing in the endoplasmic reticulum, which becomes bloated, leading to cell death."
The team tested the molecule in healthy mice and noted that there were no ill effects. "It took us several years to chase down exactly which protein was being affected by ERX-41. That was the hard part. We chased many dead ends, but we did not give up," Ahn said.
"Triple-negative breast cancer is particularly insidious - it targets women at younger ages; it's aggressive, and it's treatment-resistant. I'm really glad we've discovered something that has the potential to make a significant difference for these patients," Ahn said.
Can defeat the deadliest cancer
The researchers then fed the compound to mice with human forms of cancerous tumors, and they got smaller.
The molecule also killed cancer cells in human tissue that were gathered from patients who had their tumors removed.
There's more.
They found that ERX-41 is effective against other cancer types with elevated endoplasmic reticulum stress, including hard-to-treat pancreatic and ovarian cancers and glioblastoma, the most 'aggressive and lethal primary brain cancer'.
To investigate the ERX-41 molecule, Ahn worked with collaborators, including co-corresponding authors Dr. Ganesh Raj, professor of urology and pharmacology at the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center, as well as Dr. Ratna Vadlamudi, professor of obstetrics and gynecology at UT Health San Antonio. Dr. Tae-Kyung Lee, a former UTD research scientist in Ahn's Bio-Organic/Medicinal Chemistry Lab, was also involved in synthesizing the compound.
Ahn is a joint holder of patents issued and pending on ERX-41 and related compounds, which have been licensed to the Dallas-based startup EtiraRX, a company co-founded in 2018 by Ahn, Raj, and Vadlamudi. The company has announced that it plans to begin clinical trials of ERX-41 as early as the first quarter of 2023, which offers the hope of effective new treatments. to-treat cancers, including triple-negative breast cancer, leaving healthy cells unscathed.
He exploited a weakness in cells that were hitherto not targeted by the other drugs.
The study, which was carried out in isolated cells, both in human cancer tissue and in human cancers grown in mice, was published in the journal Nature Cancer.
Recently, a tiny group of people with rectal cancer saw their disease vanish after experimental treatment.
It was a very small trial done by doctors at New York's Memorial Sloan Kettering Cancer Center, wherein the patients took a drug called dostarlimab for six months. At the end of their trial, every single one of their tumors disappeared.
Now, in another breakthrough, a new compound synthesized by Dr. Jung-Mo Ahn, a University of Texas at Dallas researcher, has been found to kill a broad spectrum of hard-to-treat cancers, including triple-negative breast cancer, leaving healthy cells unscathed.
He exploited a weakness in cells that were hitherto not targeted by the other drugs.
The study, which was carried out in isolated cells, both in human cancer tissue and in human cancers grown in mice, was published in the journal Nature Cancer.
Only a few options for patients with triple-negative breast cancer
Ahn, a co-corresponding author of the study and a UT Dallas associate professor of chemistry and biochemistry in the School of Natural Sciences and Mathematics, has been working on small molecules that target protein-protein interactions in cells for more than a decade. Previously, he had developed potential therapeutic candidate compounds for treatment-resistant breast cancer and prostate cancer.
In his current research, Ahn and his colleagues tested a new compound he synthesized called ERX-41 for its effects on breast cancer cells - those that contained estrogen receptors (ERs) and those that do not.
Now, there are effective treatments for patients with ER-positive breast cancer, but only a few treatment options for patients with triple-negative breast cancer (TNBC) exist. It lacks receptors for estrogen, progesterone, and human epidermal growth factor 2. TNBC is known to affect women under 40 and has worse outcomes than other types of breast cancer.
"The ERX-41 compound did not kill healthy cells, but it wiped out tumor cells regardless of whether the cancer cells had estrogen receptors," Ahn said. "In fact, it killed the triple-negative breast cancer cells better than it killed the ER-positive cells.
"This was puzzling to us at the time. We knew it must be targeting something other than estrogen receptors in the TNBC cells, but we didn't know what that was."
Soon, the researchers discovered that ERX-41 binds to lysosomal acid lipase A (LIPA), a cellular protein. LIPA is found in a cell structure called the endoplasmic reticulum, an organelle that processes and folds proteins.
"For a tumor cell to grow quickly, it has to produce a lot of proteins, and this creates stress on the endoplasmic reticulum," Ahn said. "Cancer cells significantly overproduce LIPA, much more so than healthy cells. By binding to LIPA, ERX-41 jams the protein processing in the endoplasmic reticulum, which becomes bloated, leading to cell death."
The team tested the molecule in healthy mice and noted that there were no ill effects. "It took us several years to chase down exactly which protein was being affected by ERX-41. That was the hard part. We chased many dead ends, but we did not give up," Ahn said.
"Triple-negative breast cancer is particularly insidious - it targets women at younger ages; it's aggressive, and it's treatment-resistant. I'm really glad we've discovered something that has the potential to make a significant difference for these patients," Ahn said.
Can defeat the deadliest cancer
The researchers then fed the compound to mice with human forms of cancerous tumors, and they got smaller.
The molecule also killed cancer cells in human tissue that were gathered from patients who had their tumors removed.
There's more.
They found that ERX-41 is effective against other cancer types with elevated endoplasmic reticulum stress, including hard-to-treat pancreatic and ovarian cancers and glioblastoma, the most 'aggressive and lethal primary brain cancer'.
To investigate the ERX-41 molecule, Ahn worked with collaborators, including co-corresponding authors Dr. Ganesh Raj, professor of urology and pharmacology at the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center, as well as Dr. Ratna Vadlamudi, professor of obstetrics and gynecology at UT Health San Antonio. Dr. Tae-Kyung Lee, a former UTD research scientist in Ahn's Bio-Organic/Medicinal Chemistry Lab, was also involved in synthesizing the compound.
Ahn is a joint holder of patents issued and pending on ERX-41 and related compounds, which have been licensed to the Dallas-based startup EtiraRX, a company co-founded in 2018 by Ahn, Raj, and Vadlamudi. The company has announced that it plans to begin clinical trials of ERX-41 as early as the first quarter of 2023, which offers the hope of effective new treatments.
Praise God. Could this be the end of that horrible disease?
Maybe they should call in Bidenodeum. After all, Biden destroys everything that he comes in contact with.
Thanks for the post.
When I was a toddler, my father was not expected to live through the night. My mother prayed all night. In the depth of night, she gave up and said, "I don't know what I will do." Suddenly she felt peace come over her. Outside, in the darkness, through a 3d story window, as she later said, "Somebody was out there. I don't know whether it was Jesus or an angel or what. But somebody was out there. And suddenly I just knew that everything would be all right." My father got well and lived until I was a teenager.
As a physician, I have seen two cases of advanced cancer cured by prayer.
Pray for a cure for all hideous diseases.
There seems to be an abunance of stories lately about cancer cures. I hope they are real and not yet another distraction.
Biden will say he cured cancer.
I smell Fauci.
ping!
My sister has been fighting breast cancer for years—years. It eventually breached brain barrier and things were not looking good. She got into a study with new drug, and within months was cancer free. Things are turning. I can feel it
What a great discovery!
What are the not-yet-stated side effects?
This will causethe bilderberg group to come up with new ways to control the population
Remember when Biden said this.
“That’s why I’ve worked so hard in my career to make sure that... I promise you if I’m elected president, you’re going to see the single most important thing that changes America, we’re gonna cure cancer,” Biden declared.
Thanks, Joe! /s
If this stuff really works these scientists had better invest in some seriously good security. Big Pharma is not above ‘Arkancide’. I am also willing to bet that the FedGov is watching closely so they can exclude this drug from any MediCare programs.
DS will NEVER allow the “unwashed masses” to have it....too much money and under the table payoffs to be made.
It will only be reserved for our “elite rulers”...and no one else.
Educated in Korea with his PHD from University of Arizona.
No Ivy Leagues on his resume.
Nope. I don’t remember that. Then again, I make it a point to ignore the sonovabitch whenever possible.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.