Study shows postbiotic Urolithin A improves muscle strength and exercise performance in middle aged adults (Available a a supplement now)

Medical Xpress / Ecole Polytechnique Federale de Lausanne / Cell Reports Medicine ^ | May 17, 2022 | Anurag Singh et al

[ConservativeMind]

Age-associated muscle decline can start as early as 40 years old and there are currently no effective interventions to counteract it other than exercise. A new milestone study showed that daily intake of Amazentis' proprietary Urolithin A, Mitopure, significantly improved muscle strength by 12% after four months. These findings further validate Mitopure's benefits for muscle and mitochondrial health and show it is safe and well tolerated. Mitopure works by supporting the cells' ability to renew their powerplants, the mitochondria, during the aging process. Muscles have a high demand for energy and there are a very large number of mitochondria in muscle cells.

Previous research showed that Mitopure improved muscle endurance, reduced inflammation, and resulted in healthier mitochondrial function in older adults 65 to 90 years old.

Participants were randomized to receive daily supplementation with either 500mg, 1,000mg Mitopure or placebo for 4 months. Muscle strength, exercise performance tests and biomarkers of healthy mitochondrial function and inflammation in skeletal muscle biopsies and blood plasma were assessed at baseline, 2 months and 4 months.

Two measures of skeletal muscle strength were improved in the supplemented groups compared to the placebo group. Muscle strength in the hamstring skeletal muscle was significantly increased in both 500mg (+12%) and 1,000mg groups (+9.8%). Muscle strength during knee flexion was also significantly improved at both 500mg (+10.6%) and 1,000mg doses (+10.5%).

Clinically meaningful improvements on aerobic endurance (+ 10% in peak oxygen consumption [VO2]), physical performance (+ 33 meters on the 6 min walk test), and power output (+5%) were observed in the 1,000mg group, though not statistically significant.

The blood tests and biopsies showed a significant improvement in biomarkers of healthy mitochondrial function and reduced inflammation.

[ConservativeMind]

More information, here:

GlyNAC improves multiple defects in aging to boost strength and cognition in older humans

https://freerepublic.com/focus/f-chat/4064151/posts

GlyNAC supplementation extends life span in mice (Equal parts glycine and NAC)

https://freerepublic.com/focus/f-chat/4044707/posts

[Captainpaintball]

My NAC supplement is 600 mg, but my glycine supplement is 2000 mg. I imagine that equal or greater amounts of one vs. the other is OK, too. Right?

[ConservativeMind]

That combo works.