Posted on 05/17/2022 12:57:52 PM PDT by ConservativeMind
Age-associated muscle decline can start as early as 40 years old and there are currently no effective interventions to counteract it other than exercise. A new milestone study showed that daily intake of Amazentis' proprietary Urolithin A, Mitopure, significantly improved muscle strength by 12% after four months. These findings further validate Mitopure's benefits for muscle and mitochondrial health and show it is safe and well tolerated. Mitopure works by supporting the cells' ability to renew their powerplants, the mitochondria, during the aging process. Muscles have a high demand for energy and there are a very large number of mitochondria in muscle cells.
Previous research showed that Mitopure improved muscle endurance, reduced inflammation, and resulted in healthier mitochondrial function in older adults 65 to 90 years old.
Participants were randomized to receive daily supplementation with either 500mg, 1,000mg Mitopure or placebo for 4 months. Muscle strength, exercise performance tests and biomarkers of healthy mitochondrial function and inflammation in skeletal muscle biopsies and blood plasma were assessed at baseline, 2 months and 4 months.
Two measures of skeletal muscle strength were improved in the supplemented groups compared to the placebo group. Muscle strength in the hamstring skeletal muscle was significantly increased in both 500mg (+12%) and 1,000mg groups (+9.8%). Muscle strength during knee flexion was also significantly improved at both 500mg (+10.6%) and 1,000mg doses (+10.5%).
Clinically meaningful improvements on aerobic endurance (+ 10% in peak oxygen consumption [VO2]), physical performance (+ 33 meters on the 6 min walk test), and power output (+5%) were observed in the 1,000mg group, though not statistically significant.
The blood tests and biopsies showed a significant improvement in biomarkers of healthy mitochondrial function and reduced inflammation.
(Excerpt) Read more at medicalxpress.com ...
This supplement is over $3 a day.
Bookmarked.
I’ve seen this study posted in several places.
Not sure what to make of it as yet.
Do you take this? If so what has been your experience with it.
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oh just so your post on glynac. yeah I do that.
My muscles were seriously deteriorated by age mid-50.
Long work hours at job, too tired after work to exercise.
I had irregular heart beats, chest pain after a good restaurant meal, 140/90 BP, was diagnosed border line diabetic from higher H1C, panic attacks in closed malls, hip joint pain, and fainting spells at work in morning.
Quit my well paying secure government job, and joined a cheap golf club where I could play unlimited rounds for fixed monthly dues. In just 2 short years, I was playing 5 rounds of 18 every week, pushing my golf club card on a hilly gold course (Orchard hills country club). Miraculously every one of my health issues disappeared, without taking any medications or supplements, except was on 20mg Lisinopril for 2 years to get blood pressure down. Now at age 82, I am healthy as a horse, with daily exercise of 30 minutes. I have new muscles in upper body I never had before.
My serious conclusion is people get weak and feeble with age because instead of pushing exercise, they prefer to take it easy.
Completely agree- purposeful lethargy leads to muscle atrophy.
I trained for the Olympics for a decade and work out hard every day since (at least two hours if not more). Its addictive and as much for mental health at this point.
I am approaching 59YO and have only dealt with joint issues- solely due to all the working out. The weights i lift now may not be as heavy as the weights i lifted 10 years ago- but there’s not a huge difference.
could you help me find the information on NAC + glycine?
bkmk
P4L
BKMK
I tend to agree with you.
I’m older, but was a professional athlete and remained extremely active in very heavy (as in, if you are really, really bored, you’ve seen me carrying heavy things on obscure TV channels).
It’s very much a use-it-or-lose-it situation.
I hurt, get hurt, and puke with regularity. But I’m way stronger than I was when I was in my 20s.
Here is my other suggestion. Once you get over age 45, it is best to not over stress any joints or muscles.
I am doing just great with mild exercise. At age 82, I have to be very careful to not injure anything because recovery is much slower at this age.
I don’t agree with this. It all depends on what your body is used to. The stress load on my muscles/joints has been significant over the years hence i can handle more than, say someone that’s getting back into working out after taking a decade off or never really worked out hard there lives.
I agree it all depends on what your body is used to.
Also depends on what your goal is.
My goal is simply to keep heart & lungs in good shape through regular exercise. I am not interested in any competitions or building big muscles.
All I do now is 17 minutes on treadmill with wrist weights.
And then 30 pulls of light weights on the weight machine. This is my daily routine except when I mow the lawn with a push mower or do some other hard work.
What if you took BOTH?
The effect may be additive, or it may do nothing more.
I can’t determine that. They could work on the same broken mitochondrial processes, from completely different steps in the process.
That is a great point, and hypothesis
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